INT104480

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Context Info
Confidence 0.80
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 6.59
Pain Relevance 3.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mapk9) mitochondrion (Mapk9) nucleus (Mapk9)
transcription factor binding (Mapk9) cytoplasm (Mapk9)
Anatomy Link Frequency
dorsal horn 1
Mapk9 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cva 39 99.80 Very High Very High Very High
tolerance 10 99.66 Very High Very High Very High
Dorsal horn 5 99.44 Very High Very High Very High
Sciatic nerve 5 97.48 Very High Very High Very High
Eae 4 94.24 High High
allodynia 3 92.40 High High
Central nervous system 46 90.88 High High
anesthesia 3 88.88 High High
Inflammation 53 88.48 High High
diabetic neuropathy 47 87.20 High High
Disease Link Frequency Relevance Heat
Stress 14 100.00 Very High Very High Very High
Hemorrhage 39 99.80 Very High Very High Very High
Diabetes Mellitus 67 98.96 Very High Very High Very High
Increased Venous Pressure Under Development 6 94.56 High High
Injury 4 94.24 High High
Neuropathic Pain 8 92.40 High High
INFLAMMATION 55 88.48 High High
Diabetic Neuropathy 48 87.20 High High
Stroke 3 85.68 High High
Neurodegenerative Disease 3 85.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The induction of tolerance by SLH leads to phosphorylation of both p44/42 and SAPK/JNK MAP-kinases.
Phosphorylation (phosphorylation) of SAPK associated with tolerance and cva
1) Confidence 0.80 Published 2002 Journal Shock Section Abstract Doc Link 12166775 Disease Relevance 0.85 Pain Relevance 0.64
Protein was isolated from tissues for determination of p44/42 and SAPK/JNK phosphorylation by Western blot analysis.
Phosphorylation (phosphorylation) of SAPK
2) Confidence 0.80 Published 2002 Journal Shock Section Abstract Doc Link 12166775 Disease Relevance 1.02 Pain Relevance 0.71
Phosphorylation of p44/42 and SAPK/JNK was detected in all tissues following both sham and SLH, and this effect was significantly more pronounced following SLH (P < 0.05).
Phosphorylation (Phosphorylation) of SAPK associated with cva
3) Confidence 0.80 Published 2002 Journal Shock Section Abstract Doc Link 12166775 Disease Relevance 1.04 Pain Relevance 0.72
TNF-alpha induced the phosphorylation of p38 mitogen-activated protein (MAP) kinase, stress-activated protein kinase (SAPK)/c-Jun N-terminal kinase (JNK), and p44/p42 MAP kinase.
Phosphorylation (phosphorylation) of SAPK associated with stress
4) Confidence 0.54 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19427347 Disease Relevance 0.77 Pain Relevance 0.11
The Rho-kinase inhibitors attenuated the TNF-alpha-induced phosphorylation of both p38 MAP kinase and SAPK/JNK.
Phosphorylation (phosphorylation) of SAPK
5) Confidence 0.54 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19427347 Disease Relevance 0.94 Pain Relevance 0.29
TNF-alpha induced the phosphorylation of p38 mitogen-activated protein (MAP) kinase, stress-activated protein kinase (SAPK)/c-Jun N-terminal kinase (JNK), and p44/p42 MAP kinase.
Phosphorylation (phosphorylation) of stress-activated protein kinase associated with stress
6) Confidence 0.54 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19427347 Disease Relevance 0.77 Pain Relevance 0.11
Spinal extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase phosphorylation also peak in dorsal horn astrocytes three weeks after partial sciatic nerve ligation [23].
Phosphorylation (phosphorylation) of c-Jun N-terminal kinase in dorsal horn associated with dorsal horn and sciatic nerve
7) Confidence 0.50 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1560929 Disease Relevance 0.50 Pain Relevance 0.84
upregulation of phosphorylating stress kinases like SAPK and GSK-3?
Phosphorylation (phosphorylating) of SAPK associated with stress
8) Confidence 0.39 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2323445 Disease Relevance 0.69 Pain Relevance 0.19

General Comments

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