INT104481

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Context Info
Confidence 0.50
First Reported 2001
Last Reported 2011
Negated 8
Speculated 4
Reported most in Abstract
Documents 21
Total Number 25
Disease Relevance 13.87
Pain Relevance 8.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mapk8) signal transduction (Mapk8) mitochondrion (Mapk8)
nucleus (Mapk8) kinase activity (Mapk8) cytoplasm (Mapk8)
Anatomy Link Frequency
DRG 2
neuronal 1
thyroid 1
spinal cord 1
paw 1
Mapk8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory stimuli 2 99.96 Very High Very High Very High
dorsal root ganglion 12 99.64 Very High Very High Very High
Inflammation 70 99.44 Very High Very High Very High
antagonist 13 99.24 Very High Very High Very High
Hyperalgesia 38 99.22 Very High Very High Very High
Glutamate 10 99.06 Very High Very High Very High
Stimulus evoked pain 12 98.60 Very High Very High Very High
Spinal cord 55 97.90 Very High Very High Very High
tolerance 3 97.80 Very High Very High Very High
ischemia 74 97.74 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 152 99.96 Very High Very High Very High
INFLAMMATION 84 99.78 Very High Very High Very High
Adult Respiratory Distress Syndrome 17 99.36 Very High Very High Very High
Hyperalgesia 68 99.22 Very High Very High Very High
Ganglion Cysts 20 99.16 Very High Very High Very High
Nociception 48 99.04 Very High Very High Very High
Pain 24 98.60 Very High Very High Very High
Hypersensitivity 38 98.40 Very High Very High Very High
Cv General 4 Under Development 59 97.74 Very High Very High Very High
Hemorrhage 14 97.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Under these conditions, NA inhibited only the ATP-stimulated phosphorylation of p38 in a time (30-60 min)- and dose (10-100 microM)-dependent manner, but did not affect those of ERK, JNK, or MKK3/6.
Neg (not) Regulation (affect) of JNK associated with noradrenaline
1) Confidence 0.50 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19524113 Disease Relevance 0 Pain Relevance 0.41
Nevertheless, JNK 46 kDa exhibited a much higher activation than JNK 54 kDa in the spinal cord, whereas the same noxious stimulation elicited evident activation of JNK 54 kDa in the S1 area, leaving JNK 46 kDa less affected.
Regulation (affected) of JNK in spinal cord associated with spinal cord
2) Confidence 0.45 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17923323 Disease Relevance 0.32 Pain Relevance 0.56
We examined the involvement of c-Jun N-terminal kinase (JNK) in the dorsal root ganglion (DRG) in the early phase of inflammation-induced hyperalgesia.
Spec (examined) Regulation (involvement) of JNK in DRG associated with ganglion cysts, dorsal root ganglion, hyperalgesia and inflammation
3) Confidence 0.45 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16055088 Disease Relevance 1.26 Pain Relevance 0.82
We examined the involvement of c-Jun N-terminal kinase (JNK) in the dorsal root ganglion (DRG) in the early phase of inflammation-induced hyperalgesia.
Spec (examined) Regulation (involvement) of c-Jun N-terminal kinase in DRG associated with ganglion cysts, dorsal root ganglion, hyperalgesia and inflammation
4) Confidence 0.45 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16055088 Disease Relevance 1.26 Pain Relevance 0.82
We also sought to determine which neuronal phenotypes are affected and to examine the effect of aldose reductase inhibition on JNK and c-Jun phosphorylation.
Spec (examine) Regulation (effect) of JNK in neuronal
5) Confidence 0.44 Published 2006 Journal Diabetologia Section Abstract Doc Link 16456679 Disease Relevance 0.24 Pain Relevance 0.07
Thus, mechanical hyperalgesia triggered by ET-1 in the rat hind paw depends importantly on signaling pathways involving PLC, PKC, p38 MAPK, ERK1/2, and JNK, whereas the contribution of PLA2 is relatively minor.
Regulation (depends) of JNK in paw associated with hyperalgesia
6) Confidence 0.32 Published 2006 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 16741065 Disease Relevance 0.52 Pain Relevance 0.51
Furthermore, up to date, there have been no studies addressing the issues of the significance of JNK and ERK signaling in LPS-induced acute lung injury.
Regulation (signaling) of JNK in lung associated with adult respiratory distress syndrome
7) Confidence 0.30 Published 2004 Journal Respir Res Section Body Doc Link PMC538282 Disease Relevance 0.54 Pain Relevance 0.12
These findings demonstrate that JNK is a therapeutic target for treating inflammation-induced pain hypersensitivity.
Regulation (target) of JNK associated with inflammation, hypersensitivity and stimulus evoked pain
8) Confidence 0.27 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16055088 Disease Relevance 1.49 Pain Relevance 0.96
The total amount of p38, ERK, and JNK MAPK proteins were not affected following IL-1beta injection.
Neg (not) Regulation (affected) of JNK
9) Confidence 0.27 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16033422 Disease Relevance 0.44 Pain Relevance 0.71
However, neither the phosphorylated extracellular signal-regulated kinase (p-ERK) nor phosphorylated c-Jun NH2-terminal kinase (p-JNK) was affected.
Neg (neither) Regulation (affected) of JNK
10) Confidence 0.27 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16033422 Disease Relevance 0.44 Pain Relevance 0.68
It is also reported that the highly expressed uPA in the epidermal of damaged tissue is regulated by FGF-2 which affects MAPK kinase kinase (MEKK-1) and MEKK-1's downstream NH2-terminal kinases (JNK), and extracellular signal-regulated (ERK) for controlling uPA activity [22–24].
Regulation (affects) of NH2-terminal
11) Confidence 0.26 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2997511 Disease Relevance 0 Pain Relevance 0
The ability of agmatine to regulate JNK and NF-?
Regulation (regulate) of JNK
12) Confidence 0.24 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2089075 Disease Relevance 1.18 Pain Relevance 0
In contrast to the effects of swim stress, P-JNK levels were not altered by restraint.
Neg (not) Regulation (altered) of P-JNK associated with stress
13) Confidence 0.21 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.59 Pain Relevance 0.09
Additionally, we demonstrated increased extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation without altering Jun N-terminal kinase (JNK) and p38(MAPK) phosphorylation.
Neg (without) Regulation (altering) of Jun N-terminal kinase
14) Confidence 0.21 Published 2008 Journal Neurotoxicology Section Abstract Doc Link 18845185 Disease Relevance 0.27 Pain Relevance 0.26
Taken together, these results suggest that the thyroid status could modulate the integrity of neuronal cytoskeleton acting on the endogenous NF-associated phosphorylating system and that such effect could be related to glutamate-induced excitotoxicity, as well as ERK1/2 and JNK modulation.
Regulation (modulation) of JNK in thyroid associated with glutamate
15) Confidence 0.21 Published 2008 Journal Neurotoxicology Section Abstract Doc Link 18845185 Disease Relevance 0.15 Pain Relevance 0.28
In contrast to its effects on the Erk and JNK pathways, swim stress exhibited no effect on the phosphorylation of p38MAPK in any brain region, with the exception of a small but significant increase (55%) in the hippocampus (Figs. 5 and 6).
Regulation (effects) of JNK in brain associated with stress and hippocampus
16) Confidence 0.18 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.43 Pain Relevance 0.12
Following an inflammatory stimulus, JNK, a kinase that participates in transcriptional activation, is regulated by PP2A [21].
Regulation (regulated) of JNK associated with inflammatory stimuli
17) Confidence 0.14 Published 2006 Journal Mol Pain Section Body Doc Link PMC1559591 Disease Relevance 0.19 Pain Relevance 0.22
Within the past decade, several studies in rodents have elucidated the roles of ERK, p38, JNK and ERK5 in generating nociceptive sensitivity and nociceptive plasticity.
Regulation (roles) of JNK associated with nociception
18) Confidence 0.12 Published 2008 Journal Mol Pain Section Body Doc Link PMC2391153 Disease Relevance 0.84 Pain Relevance 0.46
Three MAPK subfamilies have been well characterized: extracellular signal regulated kinase 1 and 2 (ERK1/2), c-jun N-terminal kinases (JNK) and p38-MAPK [7].
Regulation (regulated) of JNK
19) Confidence 0.12 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 1.19 Pain Relevance 0.04
The purpose of this study was to explore whether changes in p44/42 and SAPK/JNK MAP kinase activity also occur after the induction of tolerance by SLH.
Spec (whether) Regulation (changes) of JNK associated with tolerance and cva
20) Confidence 0.12 Published 2002 Journal Shock Section Abstract Doc Link 12166775 Disease Relevance 0.74 Pain Relevance 0.55

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