INT1045

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Context Info
Confidence 0.81
First Reported 1975
Last Reported 2010
Negated 4
Speculated 5
Reported most in Abstract
Documents 1211
Total Number 1217
Disease Relevance 87.04
Pain Relevance 456.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
pituitary 76
plasma 39
hypothalamus 30
neurons 24
gonadal 22
LH (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 3063 100.00 Very High Very High Very High
gABA 1066 100.00 Very High Very High Very High
Opioid 845 100.00 Very High Very High Very High
antagonist 3160 99.92 Very High Very High Very High
agonist 1921 99.92 Very High Very High Very High
opiate 923 99.92 Very High Very High Very High
Morphine 861 99.92 Very High Very High Very High
Neurotransmitter 562 99.92 Very High Very High Very High
Endogenous opioid 477 99.92 Very High Very High Very High
Clonidine 227 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 128 99.96 Very High Very High Very High
Hypoglycemia 70 99.92 Very High Very High Very High
Aids-related Complex 81 99.90 Very High Very High Very High
Stress 3985 99.82 Very High Very High Very High
Decapitation 16 99.80 Very High Very High Very High
Galactorrhea 248 99.78 Very High Very High Very High
Aging 147 99.72 Very High Very High Very High
Anovulation 8 99.70 Very High Very High Very High
Injury 129 99.44 Very High Very High Very High
Urological Neuroanatomy 201 99.38 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of an ovulation-blocking methadone treatment (5mg/kg s.c. at 13:00, 14:00 and 15:00) on preovulatory LH release was studied in Wistar and Sprague-Dawley rats.
Localization (release) of LH associated with methadone
1) Confidence 0.81 Published 1978 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 565942 Disease Relevance 0 Pain Relevance 0.36
Surges of LH release were seen significantly less often in the methadone-treated rats than in untreated or saline-injected controls, supporting the conclusion that methadone exerts its ovulation-blocking effect by preventing the CNS-controlled stimulation of pituitary LH release.
Localization (release) of LH in pituitary associated with methadone
2) Confidence 0.81 Published 1978 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 565942 Disease Relevance 0 Pain Relevance 0.44
The effects of pentobarbital (PBTL) on pulsatile LH release in ovariectomized rats were studied and characterized.
Localization (release) of LH
3) Confidence 0.81 Published 1978 Journal Neuroendocrinology Section Abstract Doc Link 732952 Disease Relevance 0 Pain Relevance 0.13
For the remaining duration of anesthesia (3-3 1/2 h) episodic LH release was characterized by decreased mean blood LH levels, a decreased rate and magnitude of increase in blood LH levels for individual episodes, and a lengthened periodicity between pulses.
Localization (release) of LH in blood associated with anesthesia
4) Confidence 0.81 Published 1978 Journal Neuroendocrinology Section Abstract Doc Link 732952 Disease Relevance 0 Pain Relevance 0.33
PBTL administration initially inhibited pulsatile LH release for 1 1/2-1 1/2 h, after which episodic release resumed.
Localization (release) of LH
5) Confidence 0.81 Published 1978 Journal Neuroendocrinology Section Abstract Doc Link 732952 Disease Relevance 0 Pain Relevance 0.31
However, though reduced, episodic LH release remained stable despite the continued influence of anesthesia.
Localization (release) of LH associated with anesthesia
6) Confidence 0.81 Published 1978 Journal Neuroendocrinology Section Abstract Doc Link 732952 Disease Relevance 0 Pain Relevance 0.38
In the fasted oestradiol-treated ovariectomized rats, naloxone was able to prevent the suppression of pulsatile LH release.
Localization (release) of LH associated with narcan
7) Confidence 0.81 Published 1991 Journal J. Endocrinol. Section Abstract Doc Link 2066689 Disease Relevance 0.09 Pain Relevance 0.50
Involvement of ovarian steroids and endogenous opioids in the fasting-induced suppression of pulsatile LH release in ovariectomized rats.
Localization (release) of LH associated with narcan and endogenous opioid
8) Confidence 0.81 Published 1991 Journal J. Endocrinol. Section Title Doc Link 2066689 Disease Relevance 0.07 Pain Relevance 0.50
Pulsatile LH release was suppressed after 48 h of fasting in the ovariectomized rats implanted with oestradiol but not in the oil-implanted controls.
Localization (release) of LH
9) Confidence 0.81 Published 1991 Journal J. Endocrinol. Section Abstract Doc Link 2066689 Disease Relevance 0.07 Pain Relevance 0.36
The participation of the ovarian steroids and opioid peptides in the suppression of pulsatile LH release during acute fasting was examined in rats.
Localization (release) of LH associated with opioid
10) Confidence 0.81 Published 1991 Journal J. Endocrinol. Section Abstract Doc Link 2066689 Disease Relevance 0.05 Pain Relevance 0.22
In the absence of oestradiol, however, naloxone was without effect on LH release in either the fasted or unfasted animals.
Localization (release) of LH associated with narcan
11) Confidence 0.81 Published 1991 Journal J. Endocrinol. Section Abstract Doc Link 2066689 Disease Relevance 0.09 Pain Relevance 0.50
These experiments indicate that the suppression of pulsatile LH release after 48 h of fasting is dependent upon oestradiol and that endogenous opioids are involved in the suppression.
Localization (release) of LH associated with endogenous opioid
12) Confidence 0.81 Published 1991 Journal J. Endocrinol. Section Abstract Doc Link 2066689 Disease Relevance 0.08 Pain Relevance 0.49
These data are not consistent with the view that naloxone exerts its effects on testosterone exclusively by altering LHRH/LH release.
Localization (release) of LH associated with narcan
13) Confidence 0.81 Published 1989 Journal Endocrinology Section Abstract Doc Link 2666108 Disease Relevance 0 Pain Relevance 0.48
These diurnal variations in receptor numbers are associated with changes in the ability of naloxone to release LH and may be crucial in the transition from the juvenile state to one of competent reproductive functioning.
Localization (release) of LH in juvenile associated with narcan
14) Confidence 0.81 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3024054 Disease Relevance 0 Pain Relevance 0.45
Association of diurnal variations in hypothalamic but not cortical opiate ([3H]-naloxone)-binding sites with the ability of naloxone to induce LH release in the prepubertal female rat.
Localization (release) of LH associated with narcan and opiate
15) Confidence 0.81 Published 1986 Journal Neuroendocrinology Section Title Doc Link 3024054 Disease Relevance 0 Pain Relevance 0.61
Similarly, progesterone co-administration to ovariectomized, oestradiol-primed rats significantly advanced and augmented LH hypersecretion.
Localization (hypersecretion) of LH
16) Confidence 0.81 Published 1988 Journal J. Endocrinol. Section Abstract Doc Link 3339293 Disease Relevance 0 Pain Relevance 0.12
Supplementation with low doses of oestradiol was itself ineffective in facilitating a spontaneous rise in LH concentration, but nalmefene co-administration significantly potentiated the ability of low doses of oestradiol to induce augmented LH secretion, in addition to advancing the timing of the spontaneous LH rise.
Localization (secretion) of LH
17) Confidence 0.81 Published 1988 Journal J. Endocrinol. Section Abstract Doc Link 3339293 Disease Relevance 0 Pain Relevance 0.11
Loss of estradiol-positive feedback action on LH release during prepubertal period in rats treated postnatally with an opiate antagonist.
Localization (release) of LH associated with antagonist and opiate
18) Confidence 0.81 Published 1986 Journal Neuroendocrinology Section Title Doc Link 3808218 Disease Relevance 0 Pain Relevance 0.69
The purpose of this study was to determine the role of endogenous opioid peptides in the differentiation of the neuroendocrine brain that leads to estradiol-dependent LH release in female but not in male rats.
Localization (release) of LH in brain associated with endogenous opioid
19) Confidence 0.81 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3808218 Disease Relevance 0 Pain Relevance 0.57
These results suggest a possible involvement of endogenous opioid peptides in the neuroendocrine brain differentiation that results in LH release after EB treatment during the prepubertal period in rats.
Localization (release) of LH in brain associated with endogenous opioid
20) Confidence 0.81 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3808218 Disease Relevance 0 Pain Relevance 0.59

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