INT104502

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Context Info
Confidence 0.78
First Reported 2002
Last Reported 2010
Negated 3
Speculated 4
Reported most in Abstract
Documents 26
Total Number 32
Disease Relevance 8.37
Pain Relevance 9.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ATPase activity (Abcc2)
Anatomy Link Frequency
liver 8
bile duct 1
SK-MEL-3 1
PNS 1
vesicles 1
Abcc2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 111 99.92 Very High Very High Very High
induced neuropathy 10 99.80 Very High Very High Very High
diclofenac 3 99.52 Very High Very High Very High
vincristine 17 99.42 Very High Very High Very High
cINOD 1 98.40 Very High Very High Very High
Morphine 6 98.22 Very High Very High Very High
Spinal cord 1 97.92 Very High Very High Very High
Bile 68 97.56 Very High Very High Very High
Eae 2 96.56 Very High Very High Very High
Peripheral nervous system 3 94.56 High High
Disease Link Frequency Relevance Heat
Cancer 156 99.98 Very High Very High Very High
Hepatotoxicity 19 99.96 Very High Very High Very High
Diabetes Mellitus 2 99.82 Very High Very High Very High
Body Weight 14 99.80 Very High Very High Very High
Neuropathic Pain 12 99.80 Very High Very High Very High
Genetic Predisposition To Disease 1 99.22 Very High Very High Very High
Shock 40 99.12 Very High Very High Very High
Sprains And Strains 3 98.80 Very High Very High Very High
INFLAMMATION 6 97.68 Very High Very High Very High
Drug Induced Neurotoxicity 6 97.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We evaluated the effect of acetaminophen (APAP), given as a single, 1g/kg body weight dose, on expression and activity of rat liver multidrug resistance-associated protein 2 (Mrp2) and P-glycoprotein (P-gp), two major canalicular drug transporters.
Gene_expression (expression) of Mrp2 in liver associated with paracetamol and body weight
1) Confidence 0.78 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15276087 Disease Relevance 0.10 Pain Relevance 0.42
In conclusion, SL administration to EE-induced cholestatic rats counteracted the decrease in bile flow and biliary excretion of glutathione and APAP-glu, a model Mrp substrate, findings associated with up-regulation of Mrp2 expression.
Gene_expression (expression) of Mrp2 in bile associated with bile
2) Confidence 0.77 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17686906 Disease Relevance 0.07 Pain Relevance 0.13
Western blot studies indicate that EE decreased the expression of multidrug resistance-associated protein 2 (Mrp2) by 41% and increased that of Mrp3 by 200%, whereas SL only affected Mrp2 expression (+60%) with respect to controls.
Gene_expression (expression) of Mrp2
3) Confidence 0.77 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17686906 Disease Relevance 0.15 Pain Relevance 0.16
The EE+SL group showed increased levels of Mrp2 and Mrp3 to the same extent as that registered for the individual treatments.
Gene_expression (levels) of Mrp2
4) Confidence 0.77 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17686906 Disease Relevance 0.15 Pain Relevance 0.16
Western blot studies indicate that EE decreased the expression of multidrug resistance-associated protein 2 (Mrp2) by 41% and increased that of Mrp3 by 200%, whereas SL only affected Mrp2 expression (+60%) with respect to controls.
Gene_expression (expression) of Mrp2
5) Confidence 0.77 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17686906 Disease Relevance 0.15 Pain Relevance 0.16
Western blot studies indicate that EE decreased the expression of multidrug resistance-associated protein 2 (Mrp2) by 41% and increased that of Mrp3 by 200%, whereas SL only affected Mrp2 expression (+60%) with respect to controls.
Gene_expression (expression) of multidrug resistance-associated protein 2
6) Confidence 0.77 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17686906 Disease Relevance 0.15 Pain Relevance 0.16
Altered expression of MRP2, MRP3 and UGT2B1 in the liver affects the disposition of morphine and its glucuronide conjugate in a rat model of cholestasis.
Gene_expression (expression) of MRP2 in liver associated with gallstones and morphine
7) Confidence 0.75 Published 2009 Journal J. Pharm. Pharmacol. Section Title Doc Link 19703370 Disease Relevance 0.10 Pain Relevance 0.33
Western blotting analysis revealed decreased Mrp2 (-41%) and increased Mrp3 (+200%) expression by EE.
Gene_expression (expression) of Mrp2
8) Confidence 0.74 Published 2006 Journal Drug Metab. Dispos. Section Abstract Doc Link 16554369 Disease Relevance 0 Pain Relevance 0.40
First, in cisplatin-induced neuropathy, this study demonstrated low MRP2 gene expression in dorsal root ganglia compared with the brain and spinal cord, which could contribute to the strong neurotoxicity of cisplatin in the PNS and particularly the dorsal root ganglia.
Gene_expression (expression) of MRP2 gene in PNS associated with drug induced neurotoxicity, peripheral nervous system, induced neuropathy, neuropathic pain and spinal cord
9) Confidence 0.73 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16859677 Disease Relevance 1.09 Pain Relevance 1.10
We evaluated the effect of acetaminophen (APAP), given as a single, 1g/kg body weight dose, on expression and activity of rat liver multidrug resistance-associated protein 2 (Mrp2) and P-glycoprotein (P-gp), two major canalicular drug transporters.
Gene_expression (expression) of resistance-associated protein 2 in liver associated with paracetamol and body weight
10) Confidence 0.68 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15276087 Disease Relevance 0.10 Pain Relevance 0.42
With a validated rat model of VCT-induced neuropathy, (1) the expressions of mdr1a (P-gp), mdr1b (P-gp), mrp1 (MRP1), and mrp2 (MRP2) genes were assessed by quantitative real-time polymerase chain reaction, and (2) the transporter activity was monitored using a radioactive tracer, (99m)Tc-sestamibi, in the CNS and PNS.
Gene_expression (expressions) of mrp2 associated with vincristine, induced neuropathy and neuropathic pain
11) Confidence 0.67 Published 2005 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 16221289 Disease Relevance 0.33 Pain Relevance 0.46
With a validated rat model of VCT-induced neuropathy, (1) the expressions of mdr1a (P-gp), mdr1b (P-gp), mrp1 (MRP1), and mrp2 (MRP2) genes were assessed by quantitative real-time polymerase chain reaction, and (2) the transporter activity was monitored using a radioactive tracer, (99m)Tc-sestamibi, in the CNS and PNS.
Gene_expression (expressions) of MRP2 associated with vincristine, induced neuropathy and neuropathic pain
12) Confidence 0.67 Published 2005 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 16221289 Disease Relevance 0.33 Pain Relevance 0.46
The biliary excretion of acetaminophen (APAP) is reduced in transport deficient (TR-) hyperbilirubinemic rats lacking the multidrug resistance-associated protein 2 (Mrp2).
Neg (lacking) Gene_expression (lacking) of Mrp2 associated with paracetamol
13) Confidence 0.64 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 16271353 Disease Relevance 0.40 Pain Relevance 0.56
Mrp2 expression not only is important in biliary excretion, but also influences the toxic potential of reactive intermediates by controlling intrahepatic GSH and possibly drug metabolism.
Gene_expression (expression) of Mrp2
14) Confidence 0.64 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 16271353 Disease Relevance 0.42 Pain Relevance 0.79
The biliary excretion of acetaminophen (APAP) is reduced in transport deficient (TR-) hyperbilirubinemic rats lacking the multidrug resistance-associated protein 2 (Mrp2).
Neg (lacking) Gene_expression (lacking) of multidrug resistance-associated protein 2 associated with paracetamol
15) Confidence 0.64 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 16271353 Disease Relevance 0.40 Pain Relevance 0.55
We conclude that induced expression of basolateral Mrp3 by EE may represent a compensatory mechanism to prevent intracellular accumulation of common Mrp substrates, either endogenous or exogenous, due to reduced expression and activity of apical Mrp2.
Gene_expression (expression) of Mrp2
16) Confidence 0.64 Published 2006 Journal Drug Metab. Dispos. Section Abstract Doc Link 16554369 Disease Relevance 0 Pain Relevance 0.48
Western analysis and confocal immunofluorescent microscopy indicated a marked increase in hepatic expression of multidrug resistance-associated protein 3 (Mrp3) in both groups pretreated with APAP, relative to expression of Mrp2.
Gene_expression (expression) of Mrp2 associated with paracetamol
17) Confidence 0.63 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16109740 Disease Relevance 0.13 Pain Relevance 1.30
Likewise, the expression of the apical membrane organic anion transporter Mrp2 (multi-drug resistance-associated protein-2), which is thought to participate in the tubular transport of MeHg–NAC (Madejczyk et al. 2007), is also low in the preweanling animal (Maher et al. 2005; Tomer et al. 2003) and may contribute to the inability of NAC to increase MeHg excretion in young animals.
Spec (may) Gene_expression (expression) of Mrp2
18) Confidence 0.59 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2199271 Disease Relevance 0.06 Pain Relevance 0.06
Effect of acetaminophen on expression and activity of rat liver multidrug resistance-associated protein 2 and P-glycoprotein.
Gene_expression (expression) of resistance-associated protein 2 in liver associated with paracetamol
19) Confidence 0.59 Published 2004 Journal Biochem. Pharmacol. Section Title Doc Link 15276087 Disease Relevance 0.16 Pain Relevance 0.70
The pharmacokinetics of morphine and its glucuronide conjugate in a rat model of streptozotocin-induced diabetes and the expression of MRP2, MRP3 and UGT2B1 in the liver.
Gene_expression (expression) of MRP2 in liver associated with diabetes mellitus and morphine
20) Confidence 0.51 Published 2010 Journal J. Pharm. Pharmacol. Section Title Doc Link 20487213 Disease Relevance 0.10 Pain Relevance 0.29

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