INT104512

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Context Info
Confidence 0.58
First Reported 2002
Last Reported 2009
Negated 0
Speculated 2
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 1.27
Pain Relevance 2.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gap43)
Anatomy Link Frequency
synapse 4
sciatic nerve 2
sympathetic 2
Gap43 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 4 100.00 Very High Very High Very High
Neurotransmitter 2 100.00 Very High Very High Very High
anesthesia 2 99.00 Very High Very High Very High
Sciatic nerve 18 98.04 Very High Very High Very High
Hippocampus 8 97.92 Very High Very High Very High
Peripheral nerve injury 3 97.16 Very High Very High Very High
monoamine 4 93.60 High High
fluoxetine 10 90.92 High High
antidepressant 6 90.44 High High
positron emission tomography 1 90.08 High High
Disease Link Frequency Relevance Heat
Nervous System Injury 8 97.72 Very High Very High Very High
Injury 12 86.68 High High
Cv Unclassified Under Development 46 85.12 High High
Parkinson's Disease 1 81.64 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 109 73.92 Quite High
Drug Induced Neurotoxicity 3 72.00 Quite High
Disease 7 62.80 Quite High
Death 2 56.08 Quite High
Apoptosis 10 50.48 Quite High
Brain Hemorrhage 3 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of FK506 on neurotransmitter content and expression of GAP-43 in neurotoxin-lesioned peripheral sensory and sympathetic neurons.
Regulation (Effect) of Gene_expression (expression) of GAP-43 in sympathetic associated with neurotransmitter and qutenza
1) Confidence 0.58 Published 2002 Journal Pharmacology Section Title Doc Link 12169765 Disease Relevance 0 Pain Relevance 0.65
Here, we also determined the effects on the expression of two other genes (synaptophysin and growth-associated protein-43 (GAP-43)) known to be involved in synapse formation and axonal growth and likely regulated by BDNF.
Spec (determined) Regulation (effects) of Spec (determined) Gene_expression (expression) of GAP-43 in synapse
2) Confidence 0.42 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17950272 Disease Relevance 0 Pain Relevance 0.50
Here, we also determined the effects on the expression of two other genes (synaptophysin and growth-associated protein-43 (GAP-43)) known to be involved in synapse formation and axonal growth and likely regulated by BDNF.
Spec (determined) Regulation (effects) of Gene_expression (expression) of growth-associated protein-43 in synapse
3) Confidence 0.37 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17950272 Disease Relevance 0 Pain Relevance 0.50
These observations might be explained by an up-regulation of growth-associated protein 43 (GAP-43) expression because improvements in neurological dysfunction were blocked by injection of MK-801 in the PBSC-treated group.
Regulation (regulation) of Gene_expression (expression) of growth-associated protein 43 associated with anesthesia
4) Confidence 0.25 Published 2009 Journal J. Neurosci. Res. Section Abstract Doc Link 19235891 Disease Relevance 0.33 Pain Relevance 0.19
Our study reveals that the decrease in acute microglial activation was associated with a long term down regulation of synaptophysin and GAP-43 expression and to a significant decrease in BDNF production.
Regulation (regulation) of Gene_expression (expression) of GAP-43
5) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779656 Disease Relevance 0.37 Pain Relevance 0.13
Therefore, as a positive control we assessed expression levels of GAP-43-IR in the ipsilateral DRG 7 days following partial sciatic nerve injury of the sciatic nerve (Seltzer et al., 1990).
Regulation (control) of Gene_expression (expression) of GAP-43-IR in sciatic nerve associated with nervous system injury and sciatic nerve
6) Confidence 0.04 Published 2007 Journal Pain Section Body Doc Link PMC2706950 Disease Relevance 0.57 Pain Relevance 0.22

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