INT104523

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Context Info
Confidence 0.12
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 20
Disease Relevance 10.09
Pain Relevance 20.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (FSCN1) cell motility (FSCN1) protein binding, bridging (FSCN1)
cytoplasm (FSCN1)
Anatomy Link Frequency
neurons 4
dorsal horns 2
microglia 2
neuronal 1
nerve 1
FSCN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal nerve ligature 690 100.00 Very High Very High Very High
Neuropathic pain 572 100.00 Very High Very High Very High
allodynia 368 100.00 Very High Very High Very High
Spinal cord 109 100.00 Very High Very High Very High
nMDA receptor 60 100.00 Very High Very High Very High
dorsal root ganglion 44 100.00 Very High Very High Very High
Dorsal horn 90 99.36 Very High Very High Very High
spinal dorsal horn 72 98.24 Very High Very High Very High
Etanercept 3 97.24 Very High Very High Very High
Kinase C 29 96.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 964 100.00 Very High Very High Very High
Ganglion Cysts 44 100.00 Very High Very High Very High
Nervous System Injury 166 99.82 Very High Very High Very High
Pain 167 95.72 Very High Very High Very High
Nociception 100 94.64 High High
Spinal Cord Injury 5 91.36 High High
Injury 55 89.52 High High
Targeted Disruption 8 77.16 Quite High
Cancer 8 75.00 Quite High
Necrosis 7 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Blockade of adenosine A1 receptors by 1,3-dipropyl-8-cyclopentylxanthine, or adenosine destruction by added adenosine deaminase, reduced the increased basal activity in SNL to baseline levels of normal dorsal horns, whereas atropine and naloxone had no effect.
Positive_regulation (increased) of SNL in dorsal horns
1) Confidence 0.12 Published 2002 Journal Anesthesiology Section Body Doc Link 12170058 Disease Relevance 0 Pain Relevance 0
This binding was significantly increased in SNL compared with normal animals.
Positive_regulation (increased) of SNL
2) Confidence 0.08 Published 2002 Journal Anesthesiology Section Body Doc Link 12170058 Disease Relevance 0 Pain Relevance 0
SNL enhanced Fos and GFAP expression in the ipsilateral spinal dorsal horn
Positive_regulation (enhanced) of SNL in dorsal horn associated with spinal dorsal horn and spinal nerve ligature
3) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736402 Disease Relevance 0.49 Pain Relevance 0.92
Inhibition of ASO on SNL-induced Fos expression occured right after the nerve injury (at 2 h after SNL).
Positive_regulation (after) of SNL in nerve associated with nervous system injury and spinal nerve ligature
4) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736402 Disease Relevance 0.31 Pain Relevance 1.00
These data together, support that early increase of Fos expression is very critical for the induction of mechanical allodynia after SNL.
Positive_regulation (critical) of SNL associated with allodynia and spinal nerve ligature
5) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736402 Disease Relevance 0.88 Pain Relevance 0.95
Thus, SNL itself produced a significant allodynia which was incubated with time; SO treatment did not change the neuropathic pain performance after SNL, while ASO treatment reversed the SNL-induced neuropathic pain with a long-lasting effect.
Neg (not) Positive_regulation (change) of SNL associated with allodynia, spinal nerve ligature and neuropathic pain
6) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736402 Disease Relevance 0.71 Pain Relevance 1.32
These data indicate that after SNL treatment, phosphorylated p38 levels in spinal cord and DRG are transiently elevated.
Positive_regulation (elevated) of SNL in spinal cord associated with spinal nerve ligature and spinal cord
7) Confidence 0.04 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12684435 Disease Relevance 0.57 Pain Relevance 1.80
protein were significantly increased in ipsilateral small- and medium-sized L5 DRG neurons after SNL.
Positive_regulation (increased) of SNL in neurons associated with dorsal root ganglion
8) Confidence 0.04 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.88 Pain Relevance 0.31
In the L5 DRG SNL transiently induces pERK in neurons at 10 min, and in satellite cells on Day 10 and 21.
Positive_regulation (induces) of SNL in satellite cells associated with spinal nerve ligature
9) Confidence 0.03 Published 2005 Journal Pain Section Abstract Doc Link 15733640 Disease Relevance 0.47 Pain Relevance 1.32
Zhuang et al [23] also observed that there was a sequential activation of neurons, microglia and astrocytes following SNL.
Positive_regulation (activation) of SNL in astrocytes associated with spinal nerve ligature
10) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 1.03 Pain Relevance 1.78
Additionally, PKA activation mediates NR1 phosphorylation in SNL-induced neuropathic pain [28].
Positive_regulation (mediates) of SNL associated with spinal nerve ligature and neuropathic pain
11) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 0.73 Pain Relevance 1.75
Compared to that of Sham-Saline group, the level of anti-phosphorylated NR1 (pNR1) was significantly increased in SNL-Saline group on POD 7 (P < 0.05 compared to Sham-Saline) (Fig 2).
Positive_regulation (increased) of SNL associated with spinal nerve ligature
12) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 0.21 Pain Relevance 1.02
SNL induced significant mechanical allodynia, astrocytic activation and NMDA receptor phosphorylation
Positive_regulation (induced) of SNL associated with allodynia, nmda receptor and spinal nerve ligature
13) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 0.50 Pain Relevance 1.66
Western blot and immunohistochemistry were performed to confirm the effects of these two agents, administered individually or together, on SNL-induced NMDA receptor phosphorylation and astrocytic activation.


Positive_regulation (activation) of SNL associated with nmda receptor and spinal nerve ligature
14) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 0.51 Pain Relevance 1.68
M) significantly activated potassium currents in both SS and SNL neurons to a similar degree at steady state.
Positive_regulation (activated) of SNL in neurons
15) Confidence 0.02 Published 2009 Journal Mol Pain Section Body Doc Link PMC2673211 Disease Relevance 0 Pain Relevance 0
Pretreatment with KT 5823 significantly reduces 8-Br-cGMP-induced KATP channel activation in both SS neurons (n = 8; p < 0.001 vs. control) and SNL neurons (n = 6; p < 0.001 vs. control).
Positive_regulation (activation) of SNL in neurons
16) Confidence 0.02 Published 2009 Journal Mol Pain Section Body Doc Link PMC2673211 Disease Relevance 0 Pain Relevance 0
M), produced similar activation of KATP channels in both SS and SNL neuronal populations.
Positive_regulation (activation) of SNL in neuronal
17) Confidence 0.02 Published 2009 Journal Mol Pain Section Body Doc Link PMC2673211 Disease Relevance 0 Pain Relevance 0
After SNL, p38 activation in spinal microglia begins on day one and peaks on day 3.
Positive_regulation (activation) of SNL in microglia associated with spinal nerve ligature
18) Confidence 0.01 Published 2007 Journal Mol Pain Section Body Doc Link PMC2186318 Disease Relevance 0.75 Pain Relevance 1.01
Zhuang et al [23] also observed that there was a sequential activation of neurons, microglia and astrocytes following SNL.
Positive_regulation (activation) of SNL in neurons associated with spinal nerve ligature
19) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 1.03 Pain Relevance 1.78
Zhuang et al [23] also observed that there was a sequential activation of neurons, microglia and astrocytes following SNL.
Positive_regulation (activation) of SNL in microglia associated with spinal nerve ligature
20) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 1.03 Pain Relevance 1.78

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