INT104527

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Context Info
Confidence 0.23
First Reported 2002
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 18
Total Number 23
Disease Relevance 14.75
Pain Relevance 19.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (FSCN1) cell motility (FSCN1) protein binding, bridging (FSCN1)
cytoplasm (FSCN1)
Anatomy Link Frequency
spinal nerve 14
dorsal root ganglia 2
nerve 1
spinal cords 1
Astrocytes 1
FSCN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
ketamine 376 100.00 Very High Very High Very High
Spinal nerve ligature 284 100.00 Very High Very High Very High
Eae 71 100.00 Very High Very High Very High
Neuropathic pain 298 99.64 Very High Very High Very High
Sciatic nerve 6 99.58 Very High Very High Very High
Spinal cord 53 99.56 Very High Very High Very High
Brush evoked pain 11 99.42 Very High Very High Very High
isoflurane 21 99.36 Very High Very High Very High
intrathecal 127 99.20 Very High Very High Very High
medulla 4 98.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Sprains And Strains 7 99.88 Very High Very High Very High
Hypersensitivity 43 99.84 Very High Very High Very High
Neuropathic Pain 600 99.64 Very High Very High Very High
Injury 34 99.60 Very High Very High Very High
Nervous System Injury 101 99.44 Very High Very High Very High
Inflammatory Pain 13 99.00 Very High Very High Very High
Hyperalgesia 45 98.36 Very High Very High Very High
Ganglion Cysts 22 97.70 Very High Very High Very High
Pain 129 97.48 Very High Very High Very High
Otitis 1 97.26 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Rats without spinal nerve ligation (SNL) failed to acquire intrathecal clonidine self-administration over 10 days of access.
SNL Binding (ligation) of in spinal nerve associated with spinal nerve ligature, clonidine and intrathecal
1) Confidence 0.23 Published 2006 Journal Pain Section Abstract Doc Link 16806709 Disease Relevance 0.52 Pain Relevance 1.76
Spinal nerve ligation (SNL)
SNL Binding (ligation) of in Spinal nerve associated with eae
2) Confidence 0.11 Published 2005 Journal Mol Pain Section Body Doc Link PMC1325266 Disease Relevance 0.58 Pain Relevance 0.90
We also examined the cold temperature sensitivity of two rodent models of neuropathic pain, the spared nerve injury (SNI) [17] and the spinal nerve ligation (SNL) [18], both of which show increased cold sensitivity using the acetone test.
SNL Spec (examined) Binding (ligation) of in nerve associated with nervous system injury, eae and neuropathic pain
3) Confidence 0.08 Published 2005 Journal Mol Pain Section Body Doc Link PMC1325266 Disease Relevance 0.60 Pain Relevance 0.56
METHODS: The spinal cords of normal animals and those that underwent left L5 and L6 spinal nerve ligation (SNL) were removed and immediately frozen.
SNL Binding (ligation) of in spinal cords
4) Confidence 0.06 Published 2002 Journal Anesthesiology Section Body Doc Link 12170058 Disease Relevance 0 Pain Relevance 0
Given this, we have examined the effects of spinal nerve ligation (SNL) on the expression of these genes.
SNL Spec (examined) Binding (ligation) of in spinal nerve associated with eae
5) Confidence 0.06 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 16246453 Disease Relevance 0.34 Pain Relevance 0.35
Immunohistochemical labeling for phosphorylated p38 (p-p38) MAPK was performed in histological sections of the rat spinal cord and medulla oblongata after the fifth lumbar (L5) spinal nerve ligation (SNL).
SNL Binding (ligation) of in spinal nerve associated with medulla, spinal nerve ligature and spinal cord
6) Confidence 0.05 Published 2008 Journal Neuroscience Section Abstract Doc Link 18440713 Disease Relevance 0.79 Pain Relevance 1.18
Ligation of the L5 spinal nerve (SNL) on one side in adult rats produces an early onset and long-lasting mechanical allodynia.
SNL Binding (Ligation) of in SNL associated with allodynia
7) Confidence 0.03 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12764087 Disease Relevance 0.59 Pain Relevance 0.71
Twenty-one days following spinal nerve ligation (SNL), animals received CRF-Saporin or control.
SNL Binding (ligation) of in spinal nerve associated with spinal nerve ligature
8) Confidence 0.03 Published 2010 Journal Neuropharmacology Section Abstract Doc Link 20470804 Disease Relevance 1.33 Pain Relevance 1.11
Rats were divided into two groups: SNL group (ligation of the L5–L6 spinal nerves; n = 31) and sham group (n = 14).
SNL Binding (ligation) of in spinal nerves
9) Confidence 0.03 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2327204 Disease Relevance 0.38 Pain Relevance 0.30
We have now investigated if ERK is activated in the spinal cord after a spinal nerve ligation (SNL) and if this contributes to the neuropathic pain-like behavior generated in this model.
SNL Binding (ligation) of in spinal nerve associated with spinal nerve ligature, neuropathic pain and spinal cord
10) Confidence 0.02 Published 2005 Journal Pain Section Abstract Doc Link 15733640 Disease Relevance 0.34 Pain Relevance 0.97
In PKCgamma wild-type mice and the outbred mouse strain ICR, ligation of the L5 and L6 spinal nerves (SNL) elicited both tactile hypersensitivity and thermal hyperalgesia.
SNL Binding (ligation) of in spinal nerves associated with thermal hyperalgesia, hypersensitivity and sprains and strains
11) Confidence 0.02 Published 2004 Journal Neuroscience Section Abstract Doc Link 14667440 Disease Relevance 1.77 Pain Relevance 1.04
Furthermore, antisense knockdown of TRPA1 suppressed cold hypersensitivity in the SNL (spinal nerve ligation) model and CFA-model of inflammatory pain in rats [23,24].
SNL Binding (ligation) of in spinal nerve associated with eae and hypersensitivity
12) Confidence 0.02 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584039 Disease Relevance 0.84 Pain Relevance 0.61
The procedure for the sham operation for spinal nerve ligation was identical to that of the SNL group, except that the spinal nerves were exposed but not ligated.
SNL Neg (not) Binding (ligated) of in spinal nerve associated with spinal nerve ligature
13) Confidence 0.02 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2327204 Disease Relevance 0.49 Pain Relevance 0.46
Spinal nerve-ligated (SNL) rats
SNL Binding (ligated) of in Spinal nerve
14) Confidence 0.02 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2327204 Disease Relevance 0.58 Pain Relevance 0.35
We compared the expression of chemokine receptor CCR2 protein in the dorsal root ganglia (DRG) injured by the chronic constriction injury (CCI), the spinal nerve ligation (SNL) and a chronic compression of DRG (CCD).
SNL Binding (ligation) of in dorsal root ganglia associated with chemokine, eae and injury
15) Confidence 0.02 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20346391 Disease Relevance 0.72 Pain Relevance 0.34
The present experiments examined the anti-inflammatory and antinociceptive activity of a selective inducible nitric oxide (iNOS) inhibitor, AR-C102222, on arachidonic acid-induced ear inflammation, Freund's complete adjuvant (FCA)-induced hyperalgesia, acetic acid-induced writhing, and tactile allodynia produced by L5 spinal nerve ligation (L5 SNL) or hindpaw incision (INC).
SNL Binding (ligation) of in spinal nerve associated with brush evoked pain, hyperalgesia, inflammation, spinal nerve ligature, otitis and antinociceptive
16) Confidence 0.02 Published 2006 Journal Eur J Pain Section Abstract Doc Link 16125426 Disease Relevance 0.95 Pain Relevance 1.09
Effects of combining ketamine with LAA on SNL-induced neuropathic pain
SNL Binding (combining) of associated with ketamine, spinal nerve ligature and neuropathic pain
17) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 0.70 Pain Relevance 1.70
Astrocytes are one of important cells type for maintenance of spinal nerve ligation (SNL)-induced neuropathic pain [21-23].
SNL Binding (ligation) of in Astrocytes associated with spinal nerve ligature and neuropathic pain
18) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 0.78 Pain Relevance 1.64
g/kg ketamine was injected into SNL rats, respectively), SNL-LAA group (n = 6 for each 3 subgroups; 10 ?
SNL Binding (group) of associated with ketamine and spinal nerve ligature
19) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 0.15 Pain Relevance 1.36
l normal saline was injected into SNL rats), SNL-Ketamine group (n = 6 for each 3 subgroups; 10 ?
SNL Binding (group) of associated with ketamine and spinal nerve ligature
20) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 0.18 Pain Relevance 1.35

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