INT104547

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Context Info
Confidence 0.59
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 24
Total Number 24
Disease Relevance 17.89
Pain Relevance 6.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il18) extracellular region (Il18) cytoplasm (Il18)
Anatomy Link Frequency
brain 6
macrophages 1
white matter 1
Il18 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 293 100.00 Very High Very High Very High
ischemia 85 99.96 Very High Very High Very High
Inflammation 358 98.72 Very High Very High Very High
intrathecal 19 98.10 Very High Very High Very High
Central nervous system 76 98.00 Very High Very High Very High
Arthritis 134 97.56 Very High Very High Very High
substance P 7 96.80 Very High Very High Very High
Neuritis 8 96.48 Very High Very High Very High
antagonist 28 95.72 Very High Very High Very High
rheumatoid arthritis 116 93.68 High High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 63 99.96 Very High Very High Very High
Hypoxia 23 99.78 Very High Very High Very High
Closed Head Injuries 103 99.72 Very High Very High Very High
Necrosis 30 99.66 Very High Very High Very High
Syndrome 7 99.52 Very High Very High Very High
Cancer 39 99.48 Very High Very High Very High
Injury 379 99.40 Very High Very High Very High
Targeted Disruption 75 99.36 Very High Very High Very High
Insulin Resistance 5 99.36 Very High Very High Very High
Corneal Perforation 1 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of IL-18 by IL-18-binding protein resulted in improved neurological recovery by 7 days, while brain edema at 24 hours was not reduced [26].
Negative_regulation (Inhibition) of IL-18 in brain associated with cerebral edema
1) Confidence 0.59 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2820471 Disease Relevance 0.87 Pain Relevance 0.13
IL-18 deficiency inhibits both Th1 and Th2 cytokine production but not the clinical symptoms in experimental autoimmune neuritis.
Negative_regulation (deficiency) of IL-18 associated with experimental autoimmune neuritis, neuritis and cytokine
2) Confidence 0.57 Published 2007 Journal J. Neuroimmunol. Section Title Doc Link 17218016 Disease Relevance 0.37 Pain Relevance 0.48
This demonstrates that inhibition of IL-18 is associated with improved recovery.
Negative_regulation (inhibition) of IL-18
3) Confidence 0.57 Published 2002 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 12172382 Disease Relevance 0.99 Pain Relevance 0.23
At 3 days after hypoxia-ischemia, IL-18 deficiency has been shown to ameliorate infarct volume and grey matter injury [10] as well as white matter injury [11] in neonatal mice.
Negative_regulation (deficiency) of IL-18 in white matter associated with hypoxia, ischemia and injury
4) Confidence 0.43 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2820471 Disease Relevance 1.19 Pain Relevance 0.25
As principal finding, we show that deficiency of IL-18 does not protect mice from ischemic brain damage after tMCAO.
Negative_regulation (deficiency) of IL-18 in brain
5) Confidence 0.43 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2820471 Disease Relevance 0.51 Pain Relevance 0
This indicates that IL-18 deficiency inhibits the production of both Th1 and Th2 cytokines in the target organ of mice with EAN.
Negative_regulation (deficiency) of IL-18 associated with neuritis and cytokine
6) Confidence 0.42 Published 2007 Journal J. Neuroimmunol. Section Abstract Doc Link 17218016 Disease Relevance 0.42 Pain Relevance 0.43
Utilising adenoviral delivery of IL-18 and TNF?
Negative_regulation (delivery) of IL-18
7) Confidence 0.42 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064903 Disease Relevance 0.73 Pain Relevance 0.37
To evaluate the functional aspects of IL-18 in the injured brain, mice were injected systemically with IL-18-binding protein (IL-18BP), a specific inhibitor of IL-18, 1 hour after trauma.
Negative_regulation (inhibitor) of IL-18 in brain associated with injury
8) Confidence 0.41 Published 2002 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 12172382 Disease Relevance 1.07 Pain Relevance 0.23
Of these human IL-18BPb and d lack the structural requirement to inhibit IL-18 action and their role remains to be determined [5].
Negative_regulation (inhibit) of IL-18
9) Confidence 0.41 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0 Pain Relevance 0.07
This form was proposed to act as a soluble negative regulator of IL-18 action by stabilizing IL-18 binding to IL-18R?
Negative_regulation (regulator) of IL-18
10) Confidence 0.41 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0 Pain Relevance 0.11
Also unexplored is the investigation of the possible role of IL-18 in CNS development suggested by work on microglial cultures from newborn mice and brain homogenates where IL-18 was preferentially expressed during early postnatal stages and subsequently downregulated, being virtually absent in the brains of adult mice [61].
Negative_regulation (downregulated) of IL-18 in brains associated with central nervous system
11) Confidence 0.41 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.14 Pain Relevance 0.22
The OVA challenge-induced IFN-gamma and ET-1 productions were inhibited in IL-18(-/-) immunized mice, as well as ET-1 production in IFN-gamma(-/-) immunized mice.
Negative_regulation (inhibited) of IL-18
12) Confidence 0.41 Published 2007 Journal Brain Behav. Immun. Section Abstract Doc Link 17194566 Disease Relevance 0.27 Pain Relevance 0.39
Transduced PEDF potently and efficaciously reduces RGC loss and vision decline in DBA/2J mice, possibly via the reduction of TNF and IL-18, and downregulation of GFAP.
Negative_regulation (reduction) of IL-18
13) Confidence 0.40 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2647972 Disease Relevance 0.39 Pain Relevance 0.09
This notion has been supported by experimental studies in rodents which demonstrated neuroprotective effects by pharmacological inhibition of either TNF or IL-18 after CHI [9-11].
Negative_regulation (inhibition) of IL-18 associated with closed head injuries
14) Confidence 0.39 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC506787 Disease Relevance 1.19 Pain Relevance 0.25
Tumor necrosis factor-mediated inhibition of interleukin-18 in the brain: a clinical and experimental study in head-injured patients and in a murine model of closed head injury.


Negative_regulation (inhibition) of interleukin-18 in brain associated with necrosis, cancer and closed head injuries
15) Confidence 0.39 Published 2004 Journal J Neuroinflammation Section Title Doc Link PMC506787 Disease Relevance 0.94 Pain Relevance 0.04
l PBS) reduced the elevated IL-18 levels in murine brains significantly to levels than were even lower than baseline concentrations (22.13 ± 7.1, P < 0.01 vs. vehicle-injected mice), as shown in Fig. 1.
Negative_regulation (reduced) of IL-18 in brains
16) Confidence 0.38 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC506787 Disease Relevance 0.58 Pain Relevance 0.13
The findings from these experimental investigations corroborate the data from the clinical study, where an inverse correlation of intrathecal TNF and IL-18 levels during the first 14 days after severe CHI was found, suggesting that the inhibition of IL-18 may represent a new potential anti-inflammatory mechanism after CHI.
Negative_regulation (inhibition) of IL-18 associated with inflammation, closed head injuries and intrathecal
17) Confidence 0.38 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC506787 Disease Relevance 0.79 Pain Relevance 0.30
The aim was to demonstrate that adoptive transfer of wild type macrophages reversed the protection produced by macrophage depletion and that adoptive transfer of macrophages deficient in IL-18 did not reverse the protection.
Negative_regulation (deficient) of IL-18 in macrophages
18) Confidence 0.29 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 1.05 Pain Relevance 0.10
In subsequent studies, it was determined that IL-18 binding protein (a natural inhibitor of IL-18) overproducing transgenic mice are protected against ischemic AKI [42].
Negative_regulation (inhibitor) of IL-18 associated with targeted disruption and injury
19) Confidence 0.29 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 1.02 Pain Relevance 0.28
The treatment significantly decreased corneal IFN-gamma and IL-18 protein levels and corneal perforation resulted.
Negative_regulation (decreased) of IL-18 associated with corneal perforation
20) Confidence 0.22 Published 2005 Journal Eur. J. Immunol. Section Abstract Doc Link 15832292 Disease Relevance 0.65 Pain Relevance 0.48

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