INT104548

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.66
First Reported 2002
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 7
Total Number 10
Disease Relevance 5.74
Pain Relevance 2.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il18) extracellular region (Il18) cytoplasm (Il18)
Anatomy Link Frequency
brain 4
spinal cord 2
pituitary 2
T cells 2
Il18 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 28 99.68 Very High Very High Very High
Central nervous system 94 98.80 Very High Very High Very High
anesthesia 7 98.60 Very High Very High Very High
rheumatoid arthritis 21 98.16 Very High Very High Very High
Paracetamol 7 96.52 Very High Very High Very High
cytokine 117 95.60 Very High Very High Very High
Glutamate 6 92.72 High High
Hippocampus 32 91.24 High High
Inflammatory mediators 5 90.68 High High
Pyramidal cell 4 88.92 High High
Disease Link Frequency Relevance Heat
Nervous System Injury 12 99.98 Very High Very High Very High
Stress 44 99.62 Very High Very High Very High
Closed Head Injuries 35 98.76 Very High Very High Very High
Brain Hemorrhage 13 98.48 Very High Very High Very High
Rheumatoid Arthritis 21 98.16 Very High Very High Very High
Hypoxia 15 97.60 Very High Very High Very High
Hepatitis 2 97.24 Very High Very High Very High
Hypertrophy 8 97.20 Very High Very High Very High
Injury 21 97.12 Very High Very High Very High
Targeted Disruption 14 95.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of the IL-18R increased NF-?
Positive_regulation (increased) of Positive_regulation (Activation) of IL-18R
1) Confidence 0.66 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.31 Pain Relevance 0.08
Here, a significant mRNA elevation for IL-18 has been reported to occur already at 3 hours, but also progressively increased until day 14 [10].
Positive_regulation (increased) of Positive_regulation (elevation) of IL-18
2) Confidence 0.50 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2820471 Disease Relevance 0.93 Pain Relevance 0.12
Significantly elevated levels of IL-18 were detected at 7 days after CHI and in human CSF up to 10 days after trauma.
Positive_regulation (elevated) of Positive_regulation (levels) of IL-18 associated with injury and closed head injuries
3) Confidence 0.45 Published 2002 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 12172382 Disease Relevance 1.12 Pain Relevance 0.18
Significantly elevated levels of IL-18 were detected at 7 days after CHI and in human CSF up to 10 days after trauma.
Positive_regulation (levels) of Positive_regulation (elevated) of IL-18 associated with injury and closed head injuries
4) Confidence 0.45 Published 2002 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 12172382 Disease Relevance 1.12 Pain Relevance 0.18
l PBS i.c.v.) induced significantly elevated IL-18 levels in brains of normal WT mice, compared to normal untreated mice, which were in a similar range as in the brain-injured groups (53.6 ± 9.6 ng/ml, Fig. 1).
Positive_regulation (induced) of Positive_regulation (elevated) of IL-18 in brain
5) Confidence 0.45 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC506787 Disease Relevance 0.41 Pain Relevance 0.05
In this respect, stress has been shown to induce transient IL-18 mRNA elevation in rat pituitary cells where increase of the IL-18 mRNA level was observed also after adrenalectomy [57].
Positive_regulation (induce) of Positive_regulation (elevation) of IL-18 in pituitary associated with stress
6) Confidence 0.45 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.47 Pain Relevance 0.20
Recently an ex vivo study found that LPS-induced IL-18 elevation in the brain was unable to affect LTP in the CA1 hippocampal subregion [77].
Positive_regulation (induced) of Positive_regulation (elevation) of IL-18 in brain
7) Confidence 0.45 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.34 Pain Relevance 0.20
In this study IL-18 stimulation failed to induce GM-CSF or osteoprotegrin from T cells.
Neg (failed) Positive_regulation (induce) of Positive_regulation (stimulation) of IL-18 in T cells
8) Confidence 0.43 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064903 Disease Relevance 0.37 Pain Relevance 0.19
In addition nerve injury induced IL-18 upregulation in rat spinal cord microglia possibly via p38 activation [47].
Spec (possibly) Positive_regulation (induced) of Spec (possibly) Positive_regulation (upregulation) of IL-18 in spinal cord associated with nervous system injury and spinal cord
9) Confidence 0.39 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.29 Pain Relevance 0.33
The significant increase of GOT and GPT activities was found to be accompanied with the elevation of hepatic TBARS level, IL-18 mRNA expression and serum IL-18 concentration, and was significantly alleviated by supplementation with 6 % S. platensis in diets.
Positive_regulation (accompanied) of Positive_regulation (elevation) of IL-18
10) Confidence 0.19 Published 2010 Journal Br. J. Nutr. Section Abstract Doc Link 20102673 Disease Relevance 0.38 Pain Relevance 0.61

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox