INT104549

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Context Info
Confidence 0.78
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 16
Total Number 18
Disease Relevance 13.01
Pain Relevance 4.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il18) extracellular region (Il18) cytoplasm (Il18)
Anatomy Link Frequency
Th1 cells 1
somatotropes 1
fibroblasts 1
Kupffer cells 1
neuronal 1
Il18 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 383 100.00 Very High Very High Very High
cytokine 241 100.00 Very High Very High Very High
chemokine 26 100.00 Very High Very High Very High
Arthritis 122 99.62 Very High Very High Very High
antagonist 76 99.08 Very High Very High Very High
rheumatoid arthritis 136 98.98 Very High Very High Very High
Pain 19 98.84 Very High Very High Very High
Central nervous system 98 94.08 High High
Multiple sclerosis 40 93.52 High High
Osteoarthritis 3 88.40 High High
Disease Link Frequency Relevance Heat
Cancer 464 100.00 Very High Very High Very High
INFLAMMATION 442 100.00 Very High Very High Very High
Hypoxia 14 100.00 Very High Very High Very High
Arthritis 129 99.62 Very High Very High Very High
Necrosis 29 99.56 Very High Very High Very High
Melanoma 34 99.30 Very High Very High Very High
Rheumatoid Arthritis 137 98.98 Very High Very High Very High
Pain 15 98.84 Very High Very High Very High
Closed Head Injuries 6 98.36 Very High Very High Very High
Sprains And Strains 12 97.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The authors investigated the posttraumatic release of IL-18 in murine brains following experimental closed head injury (CHI) and in CSF of CHI patients.
Spec (investigated) Localization (release) of IL-18 in head associated with closed head injuries
1) Confidence 0.78 Published 2002 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 12172382 Disease Relevance 0.99 Pain Relevance 0.17
was co-localized with IL-18, or growth hormone, suggesting the possibility that IL-18 acts on somatotropes through the autocrine pathway [80].
Localization (localized) of IL-18 in somatotropes
2) Confidence 0.72 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.28 Pain Relevance 0.19
Recently, IL-18 was localized in the marginal cell layer of the bovine and porcine Rathke's pouch, that is assumed to embody a stem/progenitor cell compartment of the postnatal pituitary gland [54,55].
Localization (localized) of IL-18 in pituitary gland
3) Confidence 0.67 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.16 Pain Relevance 0.11
Constitutively produced as an inactive precursor by several cell types IL-18 is secreted in its active form following maturation by caspase 1 in response to inflammatory and infectious stimuli.
Localization (secreted) of IL-18 associated with inflammation
4) Confidence 0.67 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.51 Pain Relevance 0.14
Work on IL-18 null mice, the localization of the IL-18 receptor complex in neurons and the neuronal expression of decoy isoforms of the receptor subunits are beginning to reveal the complexity and the significance of the IL-18 system in the CNS.
Localization (localization) of IL-18 in neuronal associated with central nervous system
5) Confidence 0.67 Published 2010 Journal J Neuroinflammation Section Abstract Doc Link PMC2830964 Disease Relevance 0.10 Pain Relevance 0.18
IL-18 that induces the super Th1 cells secreting IFN-?
Localization (secreting) of IL-18 in Th1 cells
6) Confidence 0.49 Published 2010 Journal Allergy, Asthma & Immunology Research Section Abstract Doc Link PMC2946701 Disease Relevance 0.60 Pain Relevance 0
SA discharges various toxins and enzymes that injure the skin, results in activation of epidermal keratinocytes, which produce and release IL-18.
Localization (release) of IL-18 in skin
7) Confidence 0.46 Published 2010 Journal Allergy, Asthma & Immunology Research Section Abstract Doc Link PMC2946701 Disease Relevance 0.59 Pain Relevance 0
Together, these cells secrete cytokines and chemokines that create a pro-inflammatory (IL-1, IL-6, IL-18 and tumor necrosis factor-?)
Localization (secrete) of IL-18 associated with chemokine, necrosis, inflammation, cancer and cytokine
8) Confidence 0.27 Published 2004 Journal J Transl Med Section Body Doc Link PMC517950 Disease Relevance 0.67 Pain Relevance 0.21
Nagai et al transfected B16F10 melanoma cells with a modified form of the IL-18 gene to enable tumor cells to secrete IL-18 [87].
Localization (secrete) of IL-18 associated with cancer and melanoma
9) Confidence 0.24 Published 2004 Journal J Transl Med Section Body Doc Link PMC455695 Disease Relevance 0.96 Pain Relevance 0
In contrast, mice with targeted deletion of the p55 or p75 TNF receptor, or of interleukin-18, displayed normal or higher pain sensitivity compared to their respective controls.
Localization (deletion) of interleukin-18 associated with pain
10) Confidence 0.23 Published 2003 Journal Pain Section Abstract Doc Link 12927619 Disease Relevance 1.08 Pain Relevance 0.86
Nagai et al transfected B16F10 melanoma cells with a modified form of the IL-18 gene to enable tumor cells to secrete IL-18 [87].
Localization (secrete) of IL-18 associated with cancer and melanoma
11) Confidence 0.22 Published 2004 Journal J Transl Med Section Body Doc Link PMC455695 Disease Relevance 0.97 Pain Relevance 0
secretion, the P2X7R has been implicated in the synthesis and release of the related leaderless cytokine IL-18 (interferon-?
Localization (release) of IL-18 associated with cytokine
12) Confidence 0.21 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1838907 Disease Relevance 0.65 Pain Relevance 0.34
and IL-18 release is inhibited by P2X7R antagonists (Finlayson et al., unpublished observations).
Localization (release) of IL-18 associated with antagonist
13) Confidence 0.21 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1838907 Disease Relevance 0.60 Pain Relevance 0.39
, secretion of IL-18 was found to be less dependent on LPS-priming [68], although conflicting data was presented by Mehta et al who found IL-18 production to be LPS-dependent [69].
Localization (secretion) of IL-18
14) Confidence 0.21 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1838907 Disease Relevance 0.59 Pain Relevance 0.34
VEGF protein and mRNA are expressed by synovial macrophages and synovial fibroblasts in the synovial tissues of RA patients, and cultured synovial cells are able to secrete VEGF under hypoxic conditions or when stimulated with IL-1, IL-6, IL-17, IL-18, -prostaglandin, or TGF-?
Localization (secrete) of IL-18 in fibroblasts associated with hypoxia and rheumatoid arthritis
15) Confidence 0.16 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2638142 Disease Relevance 1.67 Pain Relevance 0.48
In our own experiments, TLR2, TLR3, and TLR4 activation of human Kupffer cells resulted in differential secretion of IL-18 and IL-10, which coordinately regulated the activation and IFN-?
Localization (secretion) of IL-18 in Kupffer cells
16) Confidence 0.12 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2939438 Disease Relevance 0.94 Pain Relevance 0.16
Overexpression of an IL-18-binding protein using an adenoviral vector was able to ameliorate arthritis in a CIA model, indicating neutralization of IL-18 may be an effective target in the future treatment of RA [78].


Localization (neutralization) of IL-18 associated with rheumatoid arthritis and arthritis
17) Confidence 0.07 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2275302 Disease Relevance 1.30 Pain Relevance 0.92
TLR9-bearing cells recognize and respond to non-methylated CpG motifs (present at high frequency in bacterial but not vertebrate DNA), triggering an immune cascade characterized by polyclonal-B-cell activation, improved antigen uptake/presentation by antigen-presenting cells, and the secretion of chemokines and pro-inflammatory cytokines, including IL-12, IL-18, TNF-?
Localization (secretion) of IL-18 in B-cell associated with chemokine, inflammation and cytokine
18) Confidence 0.06 Published 2007 Journal Kinetoplastid Biol Dis Section Body Doc Link PMC1868746 Disease Relevance 0.34 Pain Relevance 0.15

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