INT104550

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Context Info
Confidence 0.70
First Reported 2002
Last Reported 2011
Negated 2
Speculated 6
Reported most in Body
Documents 67
Total Number 73
Disease Relevance 55.14
Pain Relevance 17.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il18) extracellular region (Il18) cytoplasm (Il18)
Anatomy Link Frequency
brain 9
optic nerve 6
retina 5
plasma 4
hippocampus 3
Il18 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 890 100.00 Very High Very High Very High
Hippocampus 234 100.00 Very High Very High Very High
Dorsal horn 28 99.88 Very High Very High Very High
Spinal cord 196 99.68 Very High Very High Very High
Angina 24 99.66 Very High Very High Very High
ischemia 203 99.62 Very High Very High Very High
depression 198 99.62 Very High Very High Very High
cva 51 99.62 Very High Very High Very High
Central nervous system 673 99.56 Very High Very High Very High
Multiple sclerosis 227 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 84 99.82 Very High Very High Very High
Stroke 161 99.80 Very High Very High Very High
Brain Injury 117 99.80 Very High Very High Very High
Cv General 3 Under Development 71 99.66 Very High Very High Very High
Stress 340 99.62 Very High Very High Very High
Depression 197 99.62 Very High Very High Very High
Cv Unclassified Under Development 121 99.62 Very High Very High Very High
Multiple Sclerosis 458 99.56 Very High Very High Very High
Hypoxia 121 99.44 Very High Very High Very High
Brain Hemorrhage 91 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Elevated IL-18 has been associated with neurological dysfunction, systemic inflammatory response syndrome (SIRS), and multiple organ dysfunction syndrome (MODS) post open-heart surgery.
Positive_regulation (Elevated) of IL-18 in heart associated with multiple organ failure, inflammatory response, anesthesia and systemic inflammatory response syndrome
1) Confidence 0.70 Published 2008 Journal Perfusion Section Abstract Doc Link 19181757 Disease Relevance 0.29 Pain Relevance 0.20
Thus, increased IL-18 during and post open-heart surgical procedures may induce left ventricular diastolic dysfunction and affect post-operative outcomes.
Positive_regulation (increased) of IL-18 in heart associated with coronary heart disease
2) Confidence 0.70 Published 2008 Journal Perfusion Section Abstract Doc Link 19181757 Disease Relevance 0.46 Pain Relevance 0.13
Although IL-18 serum levels appear elevated in the presence of coronary atherosclerosis, there is no evidence to associate this progression towards plaque instability.
Spec (appear) Positive_regulation (elevated) of IL-18 in plaque associated with coronary artery disease
3) Confidence 0.68 Published 2005 Journal Int. J. Cardiol. Section Abstract Doc Link 15676165 Disease Relevance 1.14 Pain Relevance 0.76
Regardless, elevated IL-18 levels have the potential to contribute to several of the symptoms associated with neuropsychiatric disorders.
Positive_regulation (elevated) of IL-18
4) Confidence 0.66 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 1.00 Pain Relevance 0.32
Activation of the IL-18R increased NF-?
Positive_regulation (Activation) of IL-18R
5) Confidence 0.66 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.31 Pain Relevance 0.08
In this respect, stress has been shown to induce transient IL-18 mRNA elevation in rat pituitary cells where increase of the IL-18 mRNA level was observed also after adrenalectomy [57].
Positive_regulation (induce) of IL-18 in pituitary associated with stress
6) Confidence 0.66 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.47 Pain Relevance 0.20
In the plasma, the levels of IL-18 were significantly elevated in patients with AD, vascular dementia, and mild cognitive impairment compared to the control group [107,108].
Positive_regulation (elevated) of IL-18 in plasma associated with cognitive disorder, vascular dementia and disease
7) Confidence 0.66 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 1.61 Pain Relevance 0.22
In addition, nerve injury induced a striking increase in IL-18 and IL-18R expression in the dorsal horn, and IL-18 and IL-18R were upregulated in hyperactive microglia and astrocytes, respectively [47,88].
Positive_regulation (upregulated) of IL-18R in microglia associated with nervous system injury and dorsal horn
8) Confidence 0.66 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 1.14 Pain Relevance 0.58
Coincidentally, IL-18 is also elevated after stroke, a condition followed by emotional disorders [138-140].
Positive_regulation (elevated) of IL-18 associated with stroke
9) Confidence 0.66 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.80 Pain Relevance 0.32
For instance, the levels of IL-18 transcript and protein were increased in the frontal lobe of AD patients compared to healthy age-matched controls.
Positive_regulation (increased) of IL-18 in lobe associated with disease
10) Confidence 0.66 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 1.61 Pain Relevance 0.37
In addition, nerve injury induced a striking increase in IL-18 and IL-18R expression in the dorsal horn, and IL-18 and IL-18R were upregulated in hyperactive microglia and astrocytes, respectively [47,88].
Positive_regulation (upregulated) of IL-18 in microglia associated with nervous system injury and dorsal horn
11) Confidence 0.66 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 1.15 Pain Relevance 0.58
It is thus difficult to determine whether IL-18 elevation contributes to these pathologies or whether it is a consequence of the disorders.
Spec (whether) Positive_regulation (elevation) of IL-18
12) Confidence 0.66 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.99 Pain Relevance 0.29
Upregulation of IL-18 in the optic nerve of DBA/2J mice at 5 and 6 months of age was also found (Figure 5E,F).


Positive_regulation (Upregulation) of IL-18 in optic nerve
13) Confidence 0.64 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.32 Pain Relevance 0
To determine whether IL-18 is upregulated in the retina and optic nerve of DBA/2J mice, we performed semi-quantitative RT–PCR and western blot. mRNA for IL-18 was elevated by 3 months of age, and increased almost twofold by 6 months of age as compared to IL-18 expression at 1 month of age (Figure 5A,B).
Spec (whether) Positive_regulation (upregulated) of IL-18 in retina
14) Confidence 0.64 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.28 Pain Relevance 0.06
We demonstrate that endogenous PEDF expression in retina and optic nerve of DBA/2J mice declines with age, while PEDF transfection maintains RGC viability, inhibits TNF and IL-18 upregulation, and reduces GFAP expression.
Positive_regulation (upregulation) of IL-18 in optic nerve
15) Confidence 0.64 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 1.27 Pain Relevance 0.21
These findings are coherent with data from previously published studies which demonstrated significantly elevated intracranial IL-18 levels after brain injury, both in humans as well as in experimental model systems [8,9].
Positive_regulation (elevated) of IL-18 in brain associated with brain injury
16) Confidence 0.62 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC506787 Disease Relevance 0.42 Pain Relevance 0
Here, a significant mRNA elevation for IL-18 has been reported to occur already at 3 hours, but also progressively increased until day 14 [10].
Positive_regulation (elevation) of IL-18
17) Confidence 0.50 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2820471 Disease Relevance 0.91 Pain Relevance 0.12
In our study, we investigated whether patients with established atherosclerosis, with either stable or unstable angina, possessed high levels of IL-18.
Spec (whether) Positive_regulation (levels) of IL-18 associated with angina and increased venous pressure under development
18) Confidence 0.49 Published 2005 Journal Int. J. Cardiol. Section Abstract Doc Link 15676165 Disease Relevance 1.16 Pain Relevance 0.77
encoding for a receptor subunit lacking the TIR domain arbitrarily named IL-18R?
Positive_regulation (named) of IL-18R
19) Confidence 0.48 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0 Pain Relevance 0.11
In the rat dentate gyrus, the functional effects of IL-18 were significantly attenuated by prior application of c-jun-n-terminal kinase (JNK) pathway, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) inhibitors, and a role for p38 MAPK was also suggested [48,49].
Positive_regulation (effects) of IL-18 in dentate gyrus
20) Confidence 0.48 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.31 Pain Relevance 0.13

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