INT104551

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Context Info
Confidence 0.76
First Reported 2001
Last Reported 2011
Negated 4
Speculated 3
Reported most in Body
Documents 156
Total Number 161
Disease Relevance 115.51
Pain Relevance 36.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il18) extracellular region (Il18) cytoplasm (Il18)
Anatomy Link Frequency
microglia 15
retina 11
optic nerve 11
brain 10
hippocampus 5
Il18 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 2881 100.00 Very High Very High Very High
cytokine 2287 100.00 Very High Very High Very High
Central nervous system 1372 99.96 Very High Very High Very High
Hippocampus 488 99.90 Very High Very High Very High
rheumatoid arthritis 604 99.84 Very High Very High Very High
intrathecal 100 99.82 Very High Very High Very High
Dorsal horn 56 99.68 Very High Very High Very High
ischemia 363 99.62 Very High Very High Very High
Multiple sclerosis 486 99.58 Very High Very High Very High
Arthritis 391 99.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 3260 100.00 Very High Very High Very High
Multiple Sclerosis 919 100.00 Very High Very High Very High
Arthritis 400 100.00 Very High Very High Very High
Cancer 344 100.00 Very High Very High Very High
Necrosis 237 100.00 Very High Very High Very High
Anorexia 112 100.00 Very High Very High Very High
Viral Meningitis 58 99.98 Very High Very High Very High
Rheumatoid Arthritis 604 99.84 Very High Very High Very High
Osteoporosis 36 99.84 Very High Very High Very High
Seronegative Spondarthritis 18 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover local overexpression of IL-18 binding protein c by adenoviral delivery also ameliorates articular destruction [5].
Gene_expression (overexpression) of IL-18 in articular
1) Confidence 0.76 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064903 Disease Relevance 0.75 Pain Relevance 0.34
After DMARD treatment, there was decreased tissue expression of IL-18 that correlated significantly with change in serum IL-18 and C reactive protein.
Gene_expression (expression) of IL-18
2) Confidence 0.76 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064903 Disease Relevance 0.52 Pain Relevance 0.30
Although synovial IL-18 expression has been considered the primary target, expression elsewhere in the circulation and in the lymphoid system may also be therapeutically important – we recently reported IL-18 expression in human lymph node, although its function therein is unclear [25].
Gene_expression (expression) of IL-18 in lymphoid system
3) Confidence 0.76 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064903 Disease Relevance 0.29 Pain Relevance 0.14
Although synovial IL-18 expression has been considered the primary target, expression elsewhere in the circulation and in the lymphoid system may also be therapeutically important – we recently reported IL-18 expression in human lymph node, although its function therein is unclear [25].
Gene_expression (expression) of IL-18 in lymphoid system
4) Confidence 0.76 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064903 Disease Relevance 0.21 Pain Relevance 0.11
Thus, IL-18 is present in the synovial lesion and is tractable in relevant in vivo model systems.
Gene_expression (present) of IL-18
5) Confidence 0.76 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064903 Disease Relevance 0.72 Pain Relevance 0.32
Before treatment, tissue IL-18 expression correlated with serum C reactive protein levels, but interestingly not with serum IL-18.
Gene_expression (expression) of IL-18
6) Confidence 0.76 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064903 Disease Relevance 0.54 Pain Relevance 0.30
IL-18 overexpression has been variously reported in psoriasis, pulmonary inflammatory diseases, inflammatory bowel diseases, and various tumours, and therapeutic utility likely extends to a range of inflammatory conditions.
Gene_expression (overexpression) of IL-18 in bowel associated with psoriasis, inflammation, cancer and disease
7) Confidence 0.76 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064903 Disease Relevance 1.13 Pain Relevance 0.52
We recently detected IL-18 expression in psoriatic arthritis synovium and demonstrated that such expression is maintained despite three months methotrexate therapy [30].
Gene_expression (expression) of IL-18 in synovium associated with seronegative spondarthritis, methotrexate and arthritis
8) Confidence 0.76 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064903 Disease Relevance 1.17 Pain Relevance 0.51
Before treatment, tissue IL-18 expression correlated with serum C reactive protein levels, but interestingly not with serum IL-18.
Gene_expression (expression) of IL-18
9) Confidence 0.76 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064903 Disease Relevance 0.59 Pain Relevance 0.33
Upon IL-12 stimulation, native T cells develop into TH1 cells, expressing the IL-18R?
Gene_expression (expressing) of IL-18 in T cells
10) Confidence 0.75 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.49 Pain Relevance 0.17
In addition, nerve injury induced a striking increase in IL-18 and IL-18R expression in the dorsal horn, and IL-18 and IL-18R were upregulated in hyperactive microglia and astrocytes, respectively [47,88].
Gene_expression (expression) of IL-18R in microglia associated with nervous system injury and dorsal horn
11) Confidence 0.74 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 1.04 Pain Relevance 0.57
Although other studies showed no differences in circulating IL-18 levels measured between AD patients (both mild cognitive impairment and severe AD patients) and controls [106,110,111], a significant increased production of IL-18 was obtained from stimulated blood mononuclear cells or macrophages of peripheral blood of AD patients [111,112].
Gene_expression (production) of IL-18 in macrophages associated with cognitive disorder and disease
12) Confidence 0.74 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 1.71 Pain Relevance 0.16
It was soon found that IL-18 could be synthesized centrally and its receptor subunits were now demonstrated to be broadly expressed in neurons.
Gene_expression (synthesized) of IL-18 in neurons
13) Confidence 0.74 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.63 Pain Relevance 0.28
In addition, bovine somatotropes have been shown to produce IL-18 and IL-18R?
Gene_expression (produce) of IL-18R in somatotropes
14) Confidence 0.74 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.29 Pain Relevance 0.19
In addition, IL-18 expression was elevated by restraint stress in the neurons of the medial habenula [56].
Gene_expression (expression) of IL-18 in neurons associated with stress
15) Confidence 0.74 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.55 Pain Relevance 0.26
In this respect, it was shown that mice infected with Japanese Encephalitis produce IL-18 and IL-1?
Gene_expression (produce) of IL-18 associated with viral meningitis
16) Confidence 0.74 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 1.34 Pain Relevance 0.52
For instance, infection of microglia lines with Theiler's murine encephalomyelitis virus (which causes the development of a chronic-progressive autoimmune demyelinating disease) significantly upregulates the expression of cytokines involved in innate immunity, including IL-18 [102].


Gene_expression (expression) of IL-18 in microglia associated with encephalitis, demyelinating disease, infection and cytokine
17) Confidence 0.74 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 1.89 Pain Relevance 0.41
For instance, in the mouse hippocampus the levels of IL-18 and IL-18R?
Gene_expression (levels) of IL-18 in hippocampus associated with hippocampus
18) Confidence 0.74 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.27 Pain Relevance 0.33
may induce the synthesis of IL-18, and IL-18 kinases involved in tau phosphorylation as a part of the amyloid-associated inflammatory reaction.
Gene_expression (synthesis) of IL-18 associated with inflammation, eae and alzheimer's dementia
19) Confidence 0.74 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 1.54 Pain Relevance 0.32
Also unexplored is the investigation of the possible role of IL-18 in CNS development suggested by work on microglial cultures from newborn mice and brain homogenates where IL-18 was preferentially expressed during early postnatal stages and subsequently downregulated, being virtually absent in the brains of adult mice [61].
Neg (absent) Gene_expression (expressed) of IL-18 in brains associated with central nervous system
20) Confidence 0.74 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.13 Pain Relevance 0.22

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