INT104563

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Context Info
Confidence 0.73
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 15
Disease Relevance 7.82
Pain Relevance 2.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Aqp4) plasma membrane (Aqp4) protein complex (Aqp4)
transmembrane transport (Aqp4) cytoplasm (Aqp4)
Anatomy Link Frequency
T cells 2
cochlear 1
prefrontal 1
hypothalamus 1
neurons 1
Aqp4 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 39 100.00 Very High Very High Very High
Sciatica 2 98.96 Very High Very High Very High
cocaine 6 98.40 Very High Very High Very High
Dopamine 12 96.52 Very High Very High Very High
Pain 53 96.06 Very High Very High Very High
Neuropathic pain 16 95.92 Very High Very High Very High
Nucleus accumbens 3 95.44 Very High Very High Very High
amygdala 4 94.68 High High
Multiple sclerosis 7 94.64 High High
Ventral tegmentum 2 93.44 High High
Disease Link Frequency Relevance Heat
Sprains And Strains 52 99.92 Very High Very High Very High
Hearing Impairment 1 99.82 Very High Very High Very High
Cerebral Edema 10 99.40 Very High Very High Very High
Nerve Root Compression 2 98.96 Very High Very High Very High
Neuromyelitis Optica 186 98.48 Very High Very High Very High
Neuropathic Pain 28 97.24 Very High Very High Very High
Targeted Disruption 37 96.92 Very High Very High Very High
Ocular Hypertension 2 96.86 Very High Very High Very High
Pressure And Volume Under Development 85 96.80 Very High Very High Very High
Pain 59 96.06 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition studies in the retina have demonstrated subcellular co-localization of AQP4 and Kir4.1 via both electron microscopic and co-immunoprecipitation analyses [18, 55] while Kir4.1-/- mice showed impaired retinal and cochlear physiology presumably due to altered K+ metabolism [42, 43, 48].
Localization (localization) of AQP4 in cochlear
1) Confidence 0.73 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 0.46 Pain Relevance 0.11
The clustering and precise membrane localization of Kir4.1 and AQP4 are dependent on the dystrophin gene product, Dp71 [13]–[15].
Localization (localization) of AQP4
2) Confidence 0.72 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.11 Pain Relevance 0.14
Additionally, AQP4 is localized in the Purkinje layer of the cerebellum, as well as in the supraoptic and paraventricular nuclei of the hypothalamus [32].
Localization (localized) of AQP4 in hypothalamus
3) Confidence 0.69 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 0.40 Pain Relevance 0.68
These alterations are associated with a strong decrease of Dp71, a cytoskeleton protein responsible for the localization and the clustering of Kir4.1 and AQP4.
Localization (localization) of AQP4
4) Confidence 0.67 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2754330 Disease Relevance 0.33 Pain Relevance 0.09
They aimed to identify significative alteration of AQP4 in a rat model of lumbar radiculopathy (L5 nerve root ligation) and neuropathy (L5 spinal nerve transection).
Localization (alteration) of AQP4 in nerve associated with neuropathic pain and sciatica
5) Confidence 0.64 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 1.29 Pain Relevance 0.76
This hypothesis is supported by earlier data showing that Dp71 is required for proper clustering and precise membrane localization of Kir4.1 and AQP4 channels [13]–[15].
Localization (localization) of AQP4
6) Confidence 0.63 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.20 Pain Relevance 0.07
Our findings clearly indicate that AQP4 21-40 is an immunodominant region of AQP4 in both strains.
Localization (region) of AQP4 associated with sprains and strains
7) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994828 Disease Relevance 0.10 Pain Relevance 0
Our findings clearly indicate that AQP4 21-40 is an immunodominant region of AQP4 in both strains.
Localization (region) of AQP4 associated with sprains and strains
8) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994828 Disease Relevance 0.10 Pain Relevance 0
AQP4 is the predominant water channel in the central nervous system and is localized in astrocyte foot processes, but can also be found in other organs, including kidneys, heart and lungs.
Localization (localized) of AQP4 in heart associated with central nervous system
9) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994828 Disease Relevance 1.13 Pain Relevance 0.23
Other interesting phenotypes in AQP knockout mice include reduced pain sensation, reduced intraocular pressure, defective corneal fluid transport and impaired dietary fat processing (AQP1), dry skin (AQP3), protection from brain swelling and impaired hearing/vision (AQP4), and reduced fluid secretion by salivary and airway submucosal glands (AQP5).
Localization (secretion) of AQP4 in glands associated with targeted disruption, pain, hearing impairment, cerebral edema and ocular hypertension
10) Confidence 0.47 Published 2002 Journal Ann. Med. Section Abstract Doc Link 12173689 Disease Relevance 1.19 Pain Relevance 0.10
T cells that recognized AQP4 p21-40 secreted IFN-?
Localization (secreted) of AQP4 in T cells
11) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994828 Disease Relevance 0.40 Pain Relevance 0
AQP4 p21-40-primed T cells secreted both IFN-?
Localization (secreted) of AQP4 in T cells
12) Confidence 0.46 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2994828 Disease Relevance 0.80 Pain Relevance 0.07
However, employment of in situ hybridization has been positive for significant localization of AQP4 mRNA within neurons although the hybridization signal is low [129].
Localization (localization) of AQP4 in neurons
13) Confidence 0.36 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0.19 Pain Relevance 0.03
AQP4 is the predominant water channel in the central nervous system and is localized in astrocyte foot processes, but can also be found in other organs, including kidneys, heart and lungs.
Localization (localized) of AQP4 in lungs associated with central nervous system
14) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994828 Disease Relevance 1.13 Pain Relevance 0.23
A maximal increase of prefrontal NE release was observed in control animals in response to both rewarding and aversive highly salient stimuli (WCh and IPL), and in stressed animals exposed to rewarding or aversive mildly salient stimuli (Fig. 1).
Localization (release) of WCh in prefrontal
15) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516177 Disease Relevance 0 Pain Relevance 0.05

General Comments

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