INT104564

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Context Info
Confidence 0.65
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 12
Disease Relevance 4.92
Pain Relevance 1.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Aqp3) plasma membrane (Aqp3) transmembrane transport (Aqp3)
cytoplasm (Aqp3)
Anatomy Link Frequency
basal cells 2
central nervous system 1
neuronal 1
glial cells 1
neurons 1
Aqp3 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 51 98.44 Very High Very High Very High
Pain 40 92.08 High High
Peripheral nervous system 41 88.16 High High
Sciatic nerve 6 80.24 Quite High
cocaine 3 76.48 Quite High
Spinal cord 57 76.08 Quite High
Nucleus accumbens 1 73.52 Quite High
amygdala 1 72.76 Quite High
IPN 2 71.80 Quite High
Ventral tegmentum 1 71.52 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 66 100.00 Very High Very High Very High
Convulsion 5 99.40 Very High Very High Very High
Corneal Disease 4 99.08 Very High Very High Very High
Diabetes Insipidus 9 98.92 Very High Very High Very High
Cataract 8 98.28 Very High Very High Very High
Stress 5 98.08 Very High Very High Very High
Injury 79 97.16 Very High Very High Very High
Polyuria 5 94.16 High High
Pain 43 92.08 High High
Congenital Anomalies 4 88.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have also used a similar approach to discover that p38 MAPK increases AQP 3 and 9 expression (mRNA and protein) in response to hyperosmotic stress, but only when the medium is made hyperosmotic with sucrose and not with glycerol (Bell and Watson, unpublished results).
Gene_expression (expression) of AQP 3 associated with stress
1) Confidence 0.65 Published 2008 Journal Molecular Human Reproduction Section Body Doc Link PMC2639449 Disease Relevance 0.21 Pain Relevance 0.09
The gene encoding keratocan (KERA), a proteoglycan involved in maintaining corneal shape in mice knock-out studies [15], and linked to abnormal corneal morphology (keratoconus and cornea plana) in humans, was selectively expressed in corneal tissue, as were the genes encoding lumican (LUM), a keratan sulfate-containing proteoglycan that has been shown to be important for mouse corneal transparency [16], and aquaporin 3 (AQP3), which encodes a water/small solute-transporting molecule.
Gene_expression (expressed) of aquaporin 3 in cornea associated with targeted disruption and corneal disease
2) Confidence 0.58 Published 2005 Journal Genome Biol Section Body Doc Link PMC1242209 Disease Relevance 0.53 Pain Relevance 0
Transgenic knockout mice lacking AQP1 or AQP3 are also remarkably polyuric, and knock-in mice expressing a mutant AQP2 have severe nephrogenic diabetes insipidus resulting in impaired neonatal survival.
Gene_expression (expressing) of AQP3 associated with targeted disruption and diabetes insipidus
3) Confidence 0.51 Published 2002 Journal Ann. Med. Section Abstract Doc Link 12173689 Disease Relevance 1.09 Pain Relevance 0.09
Reverse transcription-polymerase chain reaction showed expression of AQP3, AQP5 and AQP8 in neuronal primary cultures and astrocyte cultures.
Gene_expression (expression) of AQP3 in neuronal
4) Confidence 0.31 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923373 Disease Relevance 0.22 Pain Relevance 0.16
AQP3 is also expressed in different tissues including kidney collecting duct, skin, conjunctiva of the eye, oesophagus, colon, spleen, stomach, small intestine, urinary bladder and respiratory tract airway epithelium.
Gene_expression (expressed) of AQP3 in kidney collecting duct
5) Confidence 0.31 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923373 Disease Relevance 0.46 Pain Relevance 0.11
Aurélie Avril-Delplanque and colleagues (2005) tested airway epithelial cells for various cell surface antigens and found that aquaporin-3 (AQP-3) water channel expression at the cell surface is limited to basal cells.
Gene_expression (expression) of AQP-3 in basal cells
6) Confidence 0.28 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695612 Disease Relevance 0.20 Pain Relevance 0
Aurélie Avril-Delplanque and colleagues (2005) tested airway epithelial cells for various cell surface antigens and found that aquaporin-3 (AQP-3) water channel expression at the cell surface is limited to basal cells.
Gene_expression (expression) of aquaporin-3 in basal cells
7) Confidence 0.28 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695612 Disease Relevance 0.20 Pain Relevance 0
In fact, through RNase protection assay and reverse transcription-polymerase reaction (RT-PCR) they found AQP3 expression in astrocytes as well as in neurons.


Gene_expression (expression) of AQP3 in neurons
8) Confidence 0.21 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 0.32 Pain Relevance 0.43
AQP3

Unique evidence of AQP3 expression in glial cells was showed from Yamamoto et al. [108].

Gene_expression (expression) of AQP3 in glial cells
9) Confidence 0.21 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 0.35 Pain Relevance 0.47
The presence of AQP3, AQP5, and AQP8, AQP9 was reported in central nervous system (CNS) [39], but their physiological role has not been fully analyzed.


Spec (analyzed) Gene_expression (presence) of AQP3 in central nervous system associated with central nervous system
10) Confidence 0.21 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 0.44 Pain Relevance 0.42
AQP3 is also expressed in different tissues including kidney collecting duct, skin, conjunctiva of the eye, oesophagus, colon, spleen, stomach, small intestine, urinary bladder and respiratory tract airway epithelium.
Gene_expression (expressed) of AQP3 in conjunctiva
11) Confidence 0.10 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923373 Disease Relevance 0.46 Pain Relevance 0.11
AQP3 is also expressed in different tissues including kidney collecting duct, skin, conjunctiva of the eye, oesophagus, colon, spleen, stomach, small intestine, urinary bladder and respiratory tract airway epithelium.
Gene_expression (expressed) of AQP3 in skin
12) Confidence 0.10 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923373 Disease Relevance 0.46 Pain Relevance 0.11

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