INT104566

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Context Info
Confidence 0.44
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.23
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Aqp2) plasma membrane (Aqp2) protein complex (Aqp2)
transmembrane transport (Aqp2) lysosome (Aqp2) cytoplasm (Aqp2)
Anatomy Link Frequency
kidney 1
Aqp2 (Mus musculus)
Pain Link Frequency Relevance Heat
aspirin 15 76.32 Quite High
Pain 8 68.64 Quite High
Migraine 41 50.00 Quite Low
potassium channel 1 48.00 Quite Low
Spinal cord 7 33.84 Quite Low
Central nervous system 1 28.88 Quite Low
depression 4 9.04 Low Low
trigeminal ganglion 9 5.00 Very Low Very Low Very Low
headache 9 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 7 99.72 Very High Very High Very High
Polyuria 1 99.60 Very High Very High Very High
Diabetes Insipidus 2 98.68 Very High Very High Very High
Congenital Anomalies 1 96.00 Very High Very High Very High
Cataract 1 95.52 Very High Very High Very High
Disease 5 82.88 Quite High
Pain 8 68.64 Quite High
Ocular Hypertension 2 66.72 Quite High
Cerebral Edema 2 56.08 Quite High
Hearing Impairment 1 54.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Humans lacking AQP1 or AQP2 manifest polyuria with defective urinary concentrating ability and humans with mutations in MIP (AQP0) develop cataracts.
Negative_regulation (lacking) of AQP2 associated with polyuria and cataract
1) Confidence 0.44 Published 2002 Journal Ann. Med. Section Abstract Doc Link 12173689 Disease Relevance 0.95 Pain Relevance 0.07
In fact, this enzyme has been found to be involved in the downregulation of AQP2 in the kidney [30], and is expressed in Deiters' cells, where it is modulated by sound conditioning, possibly through mechanically sensitive pathways [31].
Negative_regulation (downregulation) of AQP2 in kidney
2) Confidence 0.24 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2810475 Disease Relevance 0 Pain Relevance 0.04
Defects in AQP-2 have been shown to be linked to nephrogenic diabetes insipidus [33,34].
Negative_regulation (Defects) of AQP-2 associated with diabetes insipidus
3) Confidence 0.12 Published 2010 Journal Mol Pain Section Body Doc Link PMC2974658 Disease Relevance 0.28 Pain Relevance 0

General Comments

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