INT104568

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Context Info
Confidence 0.36
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 2.47
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Aqp1) transmembrane transporter activity (Aqp1) plasma membrane (Aqp1)
nucleus (Aqp1) transmembrane transport (Aqp1) cytoplasm (Aqp1)
Anatomy Link Frequency
glands 4
Aqp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 2 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cerebral Edema 4 100.00 Very High Very High Very High
Ocular Hypertension 4 100.00 Very High Very High Very High
Hearing Impairment 2 100.00 Very High Very High Very High
Pain 2 99.76 Very High Very High Very High
Targeted Disruption 12 99.24 Very High Very High Very High
Diabetes Insipidus 2 95.04 Very High Very High Very High
Cataract 2 88.52 High High
Polyuria 2 84.40 Quite High
Congenital Anomalies 2 78.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Other interesting phenotypes in AQP knockout mice include reduced pain sensation, reduced intraocular pressure, defective corneal fluid transport and impaired dietary fat processing (AQP1), dry skin (AQP3), protection from brain swelling and impaired hearing/vision (AQP4), and reduced fluid secretion by salivary and airway submucosal glands (AQP5).
Negative_regulation (reduced) of Localization (secretion) of AQP1 in glands associated with targeted disruption, pain, hearing impairment, cerebral edema and ocular hypertension
1) Confidence 0.36 Published 2002 Journal Ann. Med. Section Abstract Doc Link 12173689 Disease Relevance 1.22 Pain Relevance 0.10
Other interesting phenotypes in AQP knockout mice include reduced pain sensation, reduced intraocular pressure, defective corneal fluid transport and impaired dietary fat processing (AQP1), dry skin (AQP3), protection from brain swelling and impaired hearing/vision (AQP4), and reduced fluid secretion by salivary and airway submucosal glands (AQP5).
Negative_regulation (reduced) of Localization (secretion) of AQP1 in glands associated with targeted disruption, pain, hearing impairment, cerebral edema and ocular hypertension
2) Confidence 0.36 Published 2002 Journal Ann. Med. Section Abstract Doc Link 12173689 Disease Relevance 1.25 Pain Relevance 0.10

General Comments

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