INT104569

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Context Info
Confidence 0.60
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 23
Total Number 27
Disease Relevance 16.56
Pain Relevance 12.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Aqp2) plasma membrane (Aqp2) protein complex (Aqp2)
transmembrane transport (Aqp2) lysosome (Aqp2) cytoplasm (Aqp2)
Anatomy Link Frequency
trigeminal ganglia 3
dorsal root ganglia 3
Schwann cells 3
spinal cord 2
inner ear 2
Aqp2 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 120 100.00 Very High Very High Very High
Eae 69 99.72 Very High Very High Very High
Inflammation 95 99.70 Very High Very High Very High
Sciatic nerve 29 99.70 Very High Very High Very High
Spinal cord 173 99.40 Very High Very High Very High
IPN 15 99.24 Very High Very High Very High
trigeminal ganglion 45 98.68 Very High Very High Very High
Peripheral nervous system 86 98.64 Very High Very High Very High
Pain 198 98.04 Very High Very High Very High
Hippocampus 16 97.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 77 99.82 Very High Very High Very High
Inflammatory Pain 31 99.72 Very High Very High Very High
Injury 212 99.68 Very High Very High Very High
Diabetes Insipidus 6 99.48 Very High Very High Very High
Ganglion Cysts 55 98.68 Very High Very High Very High
INFLAMMATION 93 98.60 Very High Very High Very High
Neuropathic Pain 94 98.08 Very High Very High Very High
Pain 216 98.04 Very High Very High Very High
Diuresis 1 97.60 Very High Very High Very High
Natriuresis 1 97.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this work, we have evaluated the expression of AQP1 and AQP2 in the trigeminal ganglia of mice in an animal model of perioral acute inflammatory pain using immunohistochemistry and immunoblotting analysis.
Gene_expression (expression) of AQP2 in trigeminal ganglia associated with ipn
1) Confidence 0.60 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19014999 Disease Relevance 0.25 Pain Relevance 0.30
Alterations of AQP2 expression in trigeminal ganglia in a murine inflammation model.
Gene_expression (expression) of AQP2 in trigeminal ganglia associated with inflammation
2) Confidence 0.60 Published 2009 Journal Neurosci. Lett. Section Title Doc Link 19014999 Disease Relevance 0.25 Pain Relevance 0.39
To date, only AQP1, AQP2, AQP4 and AQP9 have been found in the nervous system.
Gene_expression (found) of AQP2 in nervous system
3) Confidence 0.60 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19014999 Disease Relevance 0.21 Pain Relevance 0.17
Our data have shown for the first time, the alteration of AQP2 expression in trigeminal ganglia in acute inflammatory pain showing increased and intracellular redistribution of AQP2 mainly in small-sized neurons and Schwann cells.
Gene_expression (expression) of AQP2 in Schwann cells associated with ipn
4) Confidence 0.60 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19014999 Disease Relevance 0.27 Pain Relevance 0.35
50) and Aquaporin 2 (conc. 1?
Gene_expression (conc.) of Aquaporin 2
5) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827539 Disease Relevance 0 Pain Relevance 0
Injected hAFSC expressed NPHS1, AQP2, PAX2, and OCLN, when compared to hAFSC before injection (Figure 4F).
Gene_expression (expressed) of AQP2
6) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827539 Disease Relevance 0 Pain Relevance 0
Transgenic knockout mice lacking AQP1 or AQP3 are also remarkably polyuric, and knock-in mice expressing a mutant AQP2 have severe nephrogenic diabetes insipidus resulting in impaired neonatal survival.
Gene_expression (expressing) of AQP2 associated with targeted disruption and diabetes insipidus
7) Confidence 0.50 Published 2002 Journal Ann. Med. Section Abstract Doc Link 12173689 Disease Relevance 1.08 Pain Relevance 0.09
Moreover, in the neuropathic rat model of chronic constriction injury (CCI) of sciatic nerve was assessed the alteration of AQP2 expression in DRG [7].
Gene_expression (expression) of AQP2 in sciatic nerve associated with eae, injury, neuropathic pain and sciatic nerve
8) Confidence 0.50 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 0.63 Pain Relevance 0.44
AQP2 expression is present in spinal cord, in subcortical white matter and hippocampus [28].
Gene_expression (expression) of AQP2 in spinal cord associated with hippocampus and spinal cord
9) Confidence 0.50 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 0.52 Pain Relevance 0.88
AQP2 expression undergoes interestingly changes in trigeminal ganglia during acute inflammation as reported in Fig. (2) [6].
Gene_expression (expression) of AQP2 in trigeminal ganglia associated with inflammation
10) Confidence 0.50 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 0.94 Pain Relevance 0.74
AQP2 expression increased in the cytoplasm and neuronal membrane of small-sized neurons, while the AQP2 immunostaining decreased in the cytoplasm of medium/large sized neurons with a strong increase in the neuronal membrane.
Gene_expression (expression) of AQP2 in neuronal
11) Confidence 0.50 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 0.69 Pain Relevance 0.47
CCI treatment induced a significant increase of AQP2 expression restricted to DRG and not in spinal cord.
Gene_expression (expression) of AQP2 in spinal cord associated with eae and spinal cord
12) Confidence 0.50 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 0.62 Pain Relevance 0.45
example, have reduced renal expression of AQP2 and AQP4 [46].
Gene_expression (expression) of AQP2
13) Confidence 0.47 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2643053 Disease Relevance 0.76 Pain Relevance 0.03
Moreover, CCI treatment did not induce AQP2 expression at the CCI injury site but in some small vessels of DRG.
Gene_expression (expression) of AQP2 in vessels associated with eae and injury
14) Confidence 0.38 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 0.79 Pain Relevance 0.61
AQP2 expression was recently reported also in Schwann cells of dorsal root and trigeminal ganglia during pain condition [12, 13].
Gene_expression (expression) of AQP2 in Schwann cells associated with pain
15) Confidence 0.38 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 0.10 Pain Relevance 0.39
AQP2

Many studies suggest that AQP2 is exclusively expressed in the renal collecting duct [37] but there is increasing of evidence that AQP2 is also expressed in several extra-renal locations such as the male reproductive tract [89], the inner ear [51], pancreatic islets, selected cells in gastric pits, intestinal and colonic epithelium and fallopian tubes [89].

Gene_expression (expressed) of AQP2 in inner ear
16) Confidence 0.38 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 0.45 Pain Relevance 0.28
Moreover Borsani et al. [12] in a murine inflammatory pain model showed for the first time that AQP2 is expressed also in Schwann and satellite cells of trigeminal ganglia, while in normal condition it is not found.
Gene_expression (expressed) of AQP2 in satellite cells associated with ipn
17) Confidence 0.38 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 0.40 Pain Relevance 0.57
Moreover, after chronic constriction of sciatic nerve (CCI) in rat, AQP2 expression increased in small-diameter dorsal root ganglia neurons but also in Schwann cells [13].
Gene_expression (expression) of AQP2 in dorsal root ganglia associated with sciatic nerve
18) Confidence 0.38 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 0.33 Pain Relevance 0.56
AQP2

Many studies suggest that AQP2 is exclusively expressed in the renal collecting duct [37] but there is increasing of evidence that AQP2 is also expressed in several extra-renal locations such as the male reproductive tract [89], the inner ear [51], pancreatic islets, selected cells in gastric pits, intestinal and colonic epithelium and fallopian tubes [89].

Gene_expression (expressed) of AQP2 in inner ear
19) Confidence 0.38 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 0.34 Pain Relevance 0.30
The astroglial water channel aquaporin (AQP4) is essential for the maintenance of BBB integrity.52 Antibodies to AQP4 have a highly specific role in neuromyelitis optica (NMO) and characteristically bind to cerebral microvessels, pia mater and VRSs.53 Secretin is important for other aquaporin expression via vasopressin, secretin receptor-null mice for example have reduced renal expression of AQP2 and AQP4.54 Thus VIP impairment may influence water channel function.
Gene_expression (expression) of AQP2 in pia mater associated with neuromyelitis optica
20) Confidence 0.35 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695238 Disease Relevance 1.06 Pain Relevance 0

General Comments

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