INT104570

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Context Info
Confidence 0.77
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 5.83
Pain Relevance 3.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Aqp1) transmembrane transporter activity (Aqp1) plasma membrane (Aqp1)
nucleus (Aqp1) transmembrane transport (Aqp1) cytoplasm (Aqp1)
Anatomy Link Frequency
spinal cords 2
nerve 2
endothelial cells 1
tail 1
PNS 1
Aqp1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 11 99.80 Very High Very High Very High
Peripheral nervous system 41 99.68 Very High Very High Very High
dorsal root ganglion 4 99.62 Very High Very High Very High
Spinal cord 65 99.20 Very High Very High Very High
Pain 50 97.74 Very High Very High Very High
Neuritis 4 97.22 Very High Very High Very High
Peripheral sensitization 4 94.48 High High
Central nervous system 40 93.92 High High
Neuropathic pain 10 93.52 High High
Dorsal horn 20 92.64 High High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 37 100.00 Very High Very High Very High
Cerebral Edema 34 100.00 Very High Very High Very High
Hearing Impairment 1 100.00 Very High Very High Very High
Nociception 27 99.80 Very High Very High Very High
Ganglion Cysts 22 99.62 Very High Very High Very High
Ocular Hypertension 2 98.54 Very High Very High Very High
Adhesions 4 98.26 Very High Very High Very High
Skin Cancer 4 97.80 Very High Very High Very High
Pain 53 97.74 Very High Very High Very High
Cancer 40 97.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In research published by Oshio's group, both the small neurons and small afferent nerve fibers in normal mouse dorsal root ganglion were shown the co-localization of AQP-1 and capsaicin receptor (TRPV1) [51].
Localization (localization) of AQP-1 in nerve associated with ganglion cysts, dorsal root ganglion and qutenza
1) Confidence 0.77 Published 2010 Journal Mol Pain Section Body Doc Link PMC2974658 Disease Relevance 0.78 Pain Relevance 1.21
The possibility for relating AQP-1 and nociception at spinal cord level, remains speculative.


Localization (relating) of AQP-1 in spinal cord associated with nociception and spinal cord
2) Confidence 0.72 Published 2010 Journal Mol Pain Section Body Doc Link PMC2974658 Disease Relevance 0.71 Pain Relevance 0.83
AQP1 has also an important role in synaptic vesicle swelling that is critical for secretion.
Localization (secretion) of AQP1 in synaptic vesicle associated with pressure and volume under development
3) Confidence 0.70 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 0.31 Pain Relevance 0.44
Other interesting phenotypes in AQP knockout mice include reduced pain sensation, reduced intraocular pressure, defective corneal fluid transport and impaired dietary fat processing (AQP1), dry skin (AQP3), protection from brain swelling and impaired hearing/vision (AQP4), and reduced fluid secretion by salivary and airway submucosal glands (AQP5).
Localization (secretion) of AQP1 in glands associated with targeted disruption, pain, hearing impairment, cerebral edema and ocular hypertension
4) Confidence 0.59 Published 2002 Journal Ann. Med. Section Abstract Doc Link 12173689 Disease Relevance 1.22 Pain Relevance 0.10
A role for AQPs in facilitating cell migration was first reported for AQP1 and vascular endothelial cells in mice implanted with melanoma tumours [81].
Localization (reported) of AQP1 in endothelial cells associated with cancer and skin cancer
5) Confidence 0.57 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 1.04 Pain Relevance 0.14
GAP-43 that resides in the growth cones of growing neuritis where it interacts with F-actin-associated adhesion molecules and/or extracellular matrix complexes to promote neurite extension [31], co-localized with AQP1 in both uninjured and injured spinal cords.
Localization (localized) of AQP1 in spinal cords associated with neuritis and adhesions
6) Confidence 0.57 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 1.07 Pain Relevance 0.18
Glial Fibrillary Acidic Protein (GFAP)-positive Schwann cells are known to express AQP1 too [28, 57] (Fig. (1)) but high resolution studies using electron microscopy are needed to determine the nature of AQP1-positive cells in nerve bundles and the detailed subcellular localization of AQP1 in both nerve plexuses and bundles in the PNS.


Localization (localization) of AQP1 in nerve associated with peripheral nervous system
7) Confidence 0.54 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 0.47 Pain Relevance 0.21
In particular, there has been controversy over the localization of AQP1 in the PNS.
Localization (localization) of AQP1 in PNS associated with peripheral nervous system
8) Confidence 0.54 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 0.07 Pain Relevance 0.40
The level of severity of clasping was determined according to an arbitrary scaling of clasping (from 0 to 3) based on how fast mice clasp their feet together when picked by the tail and also on their capability of releasing the posture. 0 (no clasping), 1 (reversible clasping), 2 (delayed but irreversible) and 3 (immediate and irreversible).
Localization (releasing) of delayed in tail
9) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.17 Pain Relevance 0

General Comments

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