INT104600

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Context Info
Confidence 0.43
First Reported 2002
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 7.03
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (gr)
Anatomy Link Frequency
anatomic regions 2
lungs 2
gr (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 72 97.22 Very High Very High Very High
fluoxetine 8 97.00 Very High Very High Very High
antidepressant 4 93.72 High High
Inflammation 165 92.96 High High
Hippocampus 4 55.28 Quite High
Multiple sclerosis 3 52.64 Quite High
rheumatoid arthritis 5 50.00 Quite Low
Pain 1 10.00 Low Low
cINOD 9 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 93 100.00 Very High Very High Very High
Sprains And Strains 16 99.74 Very High Very High Very High
Chronic Obstructive Pulmonary Disease 324 97.20 Very High Very High Very High
INFLAMMATION 246 97.04 Very High Very High Very High
Disease 99 91.76 High High
Rheumatoid Arthritis 5 66.76 Quite High
Nicotine Addiction 30 63.88 Quite High
Urological Neuroanatomy 4 54.64 Quite High
Demyelinating Disease 3 52.64 Quite High
Shock 3 47.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, in Balb/c mice, changes in GR and egr-1 expression can independently contribute to the phenotypes resulting from early life stress exposure.
Regulation (changes) of Gene_expression (expression) of GR associated with stress
1) Confidence 0.43 Published 2010 Journal Dev. Neurosci. Section Abstract Doc Link 20453467 Disease Relevance 0.92 Pain Relevance 0.19
These findings illustrate that the impact of early life stress on gene expression changes is modulated by the genetic background and that the persistent changes in GR and egr-1 expression that arise early during postnatal developmental are reversible by chronic fluoxetine treatment during adolescence and adulthood.
Regulation (changes) of Gene_expression (expression) of GR associated with stress and fluoxetine
2) Confidence 0.43 Published 2010 Journal Dev. Neurosci. Section Abstract Doc Link 20453467 Disease Relevance 0.79 Pain Relevance 0.20
Moreover, there was no consistent overlap of anatomic regions affected by decreased GR and egr-1 protein expression.
Regulation (affected) of Gene_expression (expression) of GR in anatomic regions
3) Confidence 0.43 Published 2010 Journal Dev. Neurosci. Section Abstract Doc Link 20453467 Disease Relevance 1.03 Pain Relevance 0.19
In contrast to the strain-independent effect of early life stress on GR expression, however, changes in egr-1 expression occurred only in Balb/c mice, and unlike the biphasic developmental changes in GR mRNA expression, egr-1 mRNA was decreased throughout postnatal development.
Neg (independent) Regulation (effect) of Gene_expression (expression) of GR associated with stress and sprains and strains
4) Confidence 0.26 Published 2010 Journal Dev. Neurosci. Section Abstract Doc Link 20453467 Disease Relevance 1.21 Pain Relevance 0.17
However, between the male patients and male controls no difference was found in GR expression nor in serum cortisol levels.
Neg (nor) Regulation (found) of Gene_expression (expression) of GR
5) Confidence 0.13 Published 2002 Journal Clin. Exp. Rheumatol. Section Body Doc Link 12175100 Disease Relevance 0.07 Pain Relevance 0
is reduced, there is no apparent change in the expression of GR?.
Neg (no) Regulation (change) of Gene_expression (expression) of GR
6) Confidence 0.08 Published 2010 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2939685 Disease Relevance 1.02 Pain Relevance 0.21
One prominent theory is that an elevation in the oxidant burden in the lungs (termed “oxidative stress”) plays a central role in both the enhancement of the inflammatory response and the development of a relative GC insensitivity.1,66 This concept is supported by experimental and mechanistic evidence and is also in alignment with other proposed mechanisms including direct disruption of GR?
Spec (proposed) Regulation (alignment) of Gene_expression (disruption) of GR in lungs associated with stress and inflammatory response
7) Confidence 0.06 Published 2010 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2939685 Disease Relevance 1.04 Pain Relevance 0.13
isoform.53 However, other studies have found low expression of GR?
Regulation (found) of Gene_expression (expression) of GR
8) Confidence 0.06 Published 2010 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2939685 Disease Relevance 0.95 Pain Relevance 0.24

General Comments

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