INT104624

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Context Info
Confidence 0.59
First Reported 2002
Last Reported 2011
Negated 0
Speculated 2
Reported most in Body
Documents 26
Total Number 28
Disease Relevance 19.25
Pain Relevance 3.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apoe) transport (Apoe) extracellular space (Apoe)
aging (Apoe) extracellular region (Apoe) Golgi apparatus (Apoe)
Anatomy Link Frequency
macrophages 2
microglia 2
brain 1
gonadal 1
leukocyte 1
Apoe (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 20 99.72 Very High Very High Very High
dexamethasone 92 99.64 Very High Very High Very High
withdrawal 10 99.40 Very High Very High Very High
cINOD 57 99.24 Very High Very High Very High
Neuritis 130 97.72 Very High Very High Very High
Inflammation 221 97.58 Very High Very High Very High
chemokine 28 94.76 High High
cytokine 115 94.28 High High
Peripheral nervous system 26 84.60 Quite High
Central nervous system 38 83.80 Quite High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 466 100.00 Very High Very High Very High
Atherosclerosis 329 100.00 Very High Very High Very High
Targeted Disruption 451 99.98 Very High Very High Very High
Syndrome 107 99.56 Very High Very High Very High
INFLAMMATION 260 99.36 Very High Very High Very High
Hyperlipidemia 28 98.88 Very High Very High Very High
Experimental Autoimmune Neuritis 130 98.68 Very High Very High Very High
Autoimmune Disease 37 98.52 Very High Very High Very High
Peritonitis 7 98.24 Very High Very High Very High
Disease 289 97.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our group used comparative proteomic methods to show a decreased level of apoE in CSF, which was later confirmed by other researchers [126, 127].
Negative_regulation (decreased) of apoE
1) Confidence 0.59 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.64 Pain Relevance 0.15
In several studies attempting to find specific biomarker of GBS in the serum and CSF, apoE was shown to decrease in CSF in GBS patients.
Negative_regulation (decrease) of apoE associated with syndrome
2) Confidence 0.43 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.61 Pain Relevance 0.16
Duan et al. in our group found that apoE deficiency enhances activation of microglia in CNS and aggravates kainic acid (KA) induced hippocampal neurodegeneration.
Negative_regulation (deficiency) of apoE in microglia
3) Confidence 0.43 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.38 Pain Relevance 0.04
Our data, in accordance with data from other studies, showed that apoE deficiency increased antigen presentation capacity of macrophages, which can explain the elevated susceptibility to EAN in apoE-deficient mice [91, 133].
Negative_regulation (deficiency) of apoE in macrophages associated with neuritis
4) Confidence 0.43 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 1.04 Pain Relevance 0.76
Previously, the authors found that apoE deficiency increased the susceptibility to experimental autoimmune neuritis (EAN), an animal model for human Guillain-Barré syndrome.
Negative_regulation (deficiency) of apoE associated with syndrome, experimental autoimmune neuritis and neuritis
5) Confidence 0.43 Published 2007 Journal Glia Section Abstract Doc Link 17357152 Disease Relevance 0.72 Pain Relevance 0.28
Apolipoprotein E deficiency enhances the antigen-presenting capacity of Schwann cells.
Negative_regulation (deficiency) of Apolipoprotein E in Schwann cells associated with disorder of lipid metabolism
6) Confidence 0.43 Published 2007 Journal Glia Section Title Doc Link 17357152 Disease Relevance 0.76 Pain Relevance 0.31
Apo E deficiency does not affect nerve regeneration.
Negative_regulation (deficiency) of Apo E in nerve
7) Confidence 0.43 Published 2002 Journal J Reconstr Microsurg Section Abstract Doc Link 12177820 Disease Relevance 0.29 Pain Relevance 0.12
Interestingly, the effect of apoE on NO production is not found only in macrophages.
Negative_regulation (effect) of apoE in macrophages
8) Confidence 0.43 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.40 Pain Relevance 0.06
and transgenic mice, perhaps indicating different roles for blood leukocyte and vessel wall expressed MCP-1 in the low level apoE suppression of atherosclerosis.
Negative_regulation (suppression) of apoE in leukocyte associated with targeted disruption and atherosclerosis
9) Confidence 0.43 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2423484 Disease Relevance 0.59 Pain Relevance 0.07
Mice-deficient in apolipoprotein E (apoE?
Negative_regulation (deficient) of apolipoprotein E associated with disorder of lipid metabolism
10) Confidence 0.43 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2423484 Disease Relevance 1.51 Pain Relevance 0.13
Mice deficient in apolipoprotein E (apoE?
Negative_regulation (deficient) of apolipoprotein E associated with disorder of lipid metabolism
11) Confidence 0.43 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2423484 Disease Relevance 0.83 Pain Relevance 0
One of the most profound implications of the production of soluble apoE receptors is the possible dominant negative effect on apoE receptor function.
Spec (possible) Negative_regulation (effect) of apoE receptor
12) Confidence 0.42 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0.05 Pain Relevance 0.03
Thus, the interactions of apoE complexes with the apoE receptors in the CNS vitally affect not only the metabolism of apoE, but of A?
Negative_regulation (metabolism) of apoE
13) Confidence 0.42 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0.43 Pain Relevance 0
Interestingly, MCP-1 inhibition in apolipoprotein-E knockout mice prevents atherogenesis [73].


Negative_regulation (inhibition) of apolipoprotein-E associated with targeted disruption, atherosclerosis and disorder of lipid metabolism
14) Confidence 0.41 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2841501 Disease Relevance 1.45 Pain Relevance 0.11
When an increasing number of apoE molecules were associated with EM, both apoE3-EM and apoE4-EM induced little cholesterol release.
Negative_regulation (number) of apoE
15) Confidence 0.41 Published 2007 Journal Mol Neurodegener Section Abstract Doc Link PMC1876452 Disease Relevance 0.47 Pain Relevance 0.03
When a small number of apoE molecules were associated with EM, apoE3- and apoE4-EM, induced a marked cholesterol release to a level similar to that induced by EM alone.
Negative_regulation (number) of apoE
16) Confidence 0.41 Published 2007 Journal Mol Neurodegener Section Abstract Doc Link PMC1876452 Disease Relevance 0.57 Pain Relevance 0.04
However, our previous study showed that the level of free apoE in conditioned media and physiological fluid is underdetectable and almost all of the apoE is recovered from the HDL fraction [10].
Negative_regulation (recovered) of apoE associated with disorder of lipid metabolism
17) Confidence 0.41 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 1.22 Pain Relevance 0.04
ApoE-dose-dependent inhibition of EM-mediated lipid release
Negative_regulation (inhibition) of ApoE-dose-dependent
18) Confidence 0.41 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 0.11 Pain Relevance 0
Mice deficient in apolipoprotein E (apoE?
Negative_regulation (deficient) of apoE associated with disorder of lipid metabolism
19) Confidence 0.37 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2423484 Disease Relevance 0.83 Pain Relevance 0
Expressing very low levels of transgenic apolipoprotein E suppresses both aortic lesions and the expression of mRNA of LFA-1, VCAM-1, MCP-1, cathepsin B, and of ICAM-1 in ApoE?
Negative_regulation (otein E su) of apolipoprotein E associated with targeted disruption and disorder of lipid metabolism
20) Confidence 0.37 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2423484 Disease Relevance 1.22 Pain Relevance 0

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