INT104634

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Context Info
Confidence 0.35
First Reported 2002
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 1.79
Pain Relevance 6.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Hsd3b3) mitochondrion (Hsd3b3) oxidoreductase activity (Hsd3b3)
endoplasmic reticulum (Hsd3b3)
Anatomy Link Frequency
plasma 2
Hsd3b3 (Mus musculus)
Pain Link Frequency Relevance Heat
Restless leg syndrome 6 99.68 Very High Very High Very High
fluoxetine 22 97.54 Very High Very High Very High
Paracetamol 16 97.52 Very High Very High Very High
antagonist 6 96.84 Very High Very High Very High
gABA 8 95.68 Very High Very High Very High
cytokine 2 94.00 High High
antidepressant 16 92.76 High High
anticonvulsant 14 92.68 High High
tolerance 6 92.56 High High
agonist 8 86.44 High High
Disease Link Frequency Relevance Heat
Atherosclerosis 7 99.68 Very High Very High Very High
Disease 1 85.72 High High
Pain 1 83.28 Quite High
Convulsion 6 79.24 Quite High
Peripheral Arterial Disease 1 78.36 Quite High
Hepatotoxicity 6 75.00 Quite High
Depression 8 72.96 Quite High
Stress 2 70.32 Quite High
Alcohol Addiction 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Following the largest ever clinical trials programme in patients with IC, cilostazol, a phosophodiesterase III inhibitor, has been licensed for symptom relief in the UK.
Negative_regulation (inhibitor) of phosophodiesterase III associated with restless leg syndrome
1) Confidence 0.35 Published 2002 Journal Diabetes Obes Metab Section Abstract Doc Link 12180354 Disease Relevance 0.82 Pain Relevance 0.66
In contrast, the effect of fluoxetine was counteracted by inhibition of the neurosteroid biosynthesis using drugs like 5alpha-reductase inhibitor, finasteride; 3beta-hydroxysteroid dehydrogenase inhibitor, trilostane; 3alpha-hydroxysteroid dehydrogenase inhibitor, indomethacin; MDR antagonist, PK 11195; or the GABA(A) receptor antagonist, bicuculline.
Negative_regulation (inhibitor) of 3beta-hydroxysteroid dehydrogenase associated with gaba, antagonist and fluoxetine
2) Confidence 0.09 Published 2004 Journal Brain Res. Section Abstract Doc Link 15364024 Disease Relevance 0.15 Pain Relevance 1.27
Furthermore, inhibition of the endogenous neurosteroid biosynthesis by drugs like 5alpha-reductase inhibitor, finasteride (50 mg/kg, s.c.), 3beta-hydroxysteroid dehydrogenase inhibitor, trilostane (30 mg/kg i.p.) or 3alpha-hydroxysteroid dehydrogenase inhibitor, indomethacin (5 mg/kg, i.p.) and GABA(A) receptor antagonist, bicuculline (1 mg/kg, i.p.) blocked the antidepressant like effect of ethanol.
Negative_regulation (inhibitor) of 3beta-hydroxysteroid dehydrogenase associated with antidepressant, gaba and antagonist
3) Confidence 0.07 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12527484 Disease Relevance 0.13 Pain Relevance 0.99
Furthermore, inhibition of the endogenous neurosteroid biosynthesis by drugs like 5alpha-reductase inhibitor, finasteride (50 mg/kg, s.c.), 3beta-hydroxysteroid dehydrogenase inhibitor, trilostane (30 mg/kg i.p.) or 3alpha-hydroxysteroid dehydrogenase inhibitor, indomethacin (5 mg/kg, i.p.) and GABA(A) receptor antagonist, bicuculline (1 mg/kg, i.p.) blocked the antidepressant like effect of ethanol.
Negative_regulation (inhibitor) of 3beta-hydroxysteroid dehydrogenase associated with antidepressant, gaba and antagonist
4) Confidence 0.07 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12527484 Disease Relevance 0.13 Pain Relevance 0.99
In contrast, the effect of fluoxetine was counteracted by inhibition of the neurosteroid biosynthesis using drugs like 5alpha-reductase inhibitor, finasteride; 3beta-hydroxysteroid dehydrogenase inhibitor, trilostane; 3alpha-hydroxysteroid dehydrogenase inhibitor, indomethacin; MDR antagonist, PK 11195; or the GABA(A) receptor antagonist, bicuculline.
Negative_regulation (inhibitor) of 3beta-hydroxysteroid dehydrogenase associated with gaba, antagonist and fluoxetine
5) Confidence 0.07 Published 2004 Journal Brain Res. Section Abstract Doc Link 15364024 Disease Relevance 0.15 Pain Relevance 1.27
Acetaminophen treatment also significantly increased plasminogen activator inhibitor-1 (PAI-1) activity and plasma fibrinogen level, and decreased antithrombin III (AT-III) and protein C activities (P < 0.05).
Negative_regulation (decreased) of AT-III in plasma associated with paracetamol
6) Confidence 0.02 Published 2006 Journal Food Chem. Toxicol. Section Abstract Doc Link 16181716 Disease Relevance 0.21 Pain Relevance 0.67
SAC or SPC intake alleviated AT-III and protein C reduction (P < 0.05); but did not affect PAI-1 activity and plasma fibrinogen level (P > 0.05).
Negative_regulation (reduction) of AT-III in plasma
7) Confidence 0.01 Published 2006 Journal Food Chem. Toxicol. Section Abstract Doc Link 16181716 Disease Relevance 0.20 Pain Relevance 0.65

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