INT104671

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Context Info
Confidence 0.37
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.75
Pain Relevance 3.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Faah) Golgi apparatus (Faah) endoplasmic reticulum (Faah)
cytoplasm (Faah)
Anatomy Link Frequency
DA neurons 1
striatum 1
brain 1
Faah (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nicotine 9 99.84 Very High Very High Very High
Ventral tegmentum 7 98.24 Very High Very High Very High
Dopamine 8 98.08 Very High Very High Very High
Cannabinoid 39 96.32 Very High Very High Very High
Endocannabinoid 26 95.20 Very High Very High Very High
Nucleus accumbens 2 94.00 High High
cocaine 5 93.72 High High
Morphine 4 93.24 High High
Hippocampus 6 92.08 High High
Pain 10 91.88 High High
Disease Link Frequency Relevance Heat
Recurrence 1 98.16 Very High Very High Very High
Anxiety Disorder 63 95.76 Very High Very High Very High
Pain 8 91.88 High High
INFLAMMATION 3 91.64 High High
Cognitive Disorder 1 90.92 High High
Urological Neuroanatomy 33 86.32 High High
Increased Venous Pressure Under Development 2 82.80 Quite High
Panic Disorder 1 64.16 Quite High
Disease 1 26.96 Quite Low
Stress 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Most compounds inhibit FAAH, but not several other serine hydrolases, with potencies that depend on the size and shape of the substituents.
FAAH Binding (compounds) of
1) Confidence 0.37 Published 2003 Journal J. Med. Chem. Section Abstract Doc Link 12773040 Disease Relevance 0.18 Pain Relevance 0.24
Lipophilic N-terminal substitutions, which enhance FAAH recognition, yield potent inhibitors but render such compounds susceptible to attack by broad-spectrum hydrolases and inactive in vivo.
FAAH Binding (recognition) of
2) Confidence 0.37 Published 2009 Journal ChemMedChem Section Abstract Doc Link 19637155 Disease Relevance 0.18 Pain Relevance 0.17
Here, we studied whether effects of FAAH inhibition on nicotine-induced changes in activity of VTA DA neurons were specific for nicotine or extended to two drugs of abuse acting through different mechanisms, cocaine and morphine.
FAAH Neg (inhibition) Binding (inhibition) of in DA neurons associated with ventral tegmentum, dopamine, nicotine, morphine and cocaine
3) Confidence 0.37 Published 2010 Journal Addict Biol Section Abstract Doc Link 20477753 Disease Relevance 0.10 Pain Relevance 1.37
In the striatum, increased anandamide levels were associated with reduced FAAH and enhanced NAPE-PLD activities.
FAAH Binding (associated) of in striatum
4) Confidence 0.35 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17644084 Disease Relevance 0 Pain Relevance 0.54
Subsequently, an endogenous CB(1) receptor ligand, arachidonylethanolamide (anandamide), was isolated from porcine brain and shown to be metabolized by the enzyme arachidonylethanolamide amidohydrolase or fatty acid amide hydrolase.
fatty acid amide hydrolase Binding (metabolized) of in brain
5) Confidence 0.28 Published 2002 Journal Pharmacol. Ther. Section Abstract Doc Link 12182958 Disease Relevance 0.21 Pain Relevance 0.27
putative protein responsible for internalization of AEA and the enzyme FAAH,
FAAH Binding (internalization) of
6) Confidence 0.26 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2593468 Disease Relevance 0.81 Pain Relevance 0.44
Crystal structure of fatty acid amide hydrolase bound to the carbamate inhibitor URB597: discovery of a deacylating water molecule and insight into enzyme inactivation.
fatty acid amide hydrolase Binding (bound) of
7) Confidence 0.20 Published 2010 Journal J. Mol. Biol. Section Title Doc Link 20493882 Disease Relevance 0.27 Pain Relevance 0.23

General Comments

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