INT104672

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.14
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 4.67
Pain Relevance 1.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (Neu3) plasma membrane (Neu3) carbohydrate metabolic process (Neu3)
Anatomy Link Frequency
spinal cords 1
brains 1
Neu3 (Mus musculus)
Pain Link Frequency Relevance Heat
Endocannabinoid 8 100.00 Very High Very High Very High
Cannabinoid receptor 2 91.12 High High
Multiple sclerosis 10 90.00 High High
Cannabinoid 16 87.84 High High
cannabis 6 80.40 Quite High
Spinal cord 5 76.28 Quite High
Pain 4 72.92 Quite High
Central nervous system 3 67.52 Quite High
agonist 8 58.48 Quite High
antagonist 9 57.84 Quite High
Disease Link Frequency Relevance Heat
Multiple Sclerosis 16 99.44 Very High Very High Very High
Spasticity 10 99.06 Very High Very High Very High
Tremor 120 98.90 Very High Very High Very High
Neurological Disease 2 96.76 Very High Very High Very High
Experimental Autoimmune Encephalomyelitis 2 85.60 High High
Frailty 4 76.56 Quite High
Targeted Disruption 14 74.32 Quite High
Overactive Bladder 2 73.80 Quite High
Pain 4 72.92 Quite High
Alzheimer's Dementia 2 39.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Endocannabinoid concentrations are elevated in the brains and spinal cords of CREAE mice with spasticity, and in line with this observation, spasticity exhibited by CREAE mice can be ameliorated by inhibitors of endocannabinoid membrane transport or enzymic hydrolysis.
Negative_regulation (inhibitors) of membrane in spinal cords associated with endocannabinoid, multiple sclerosis and spasticity
1) Confidence 0.14 Published 2002 Journal Pharmacol. Ther. Section Abstract Doc Link 12182963 Disease Relevance 1.67 Pain Relevance 0.86
Endocannabinoid concentrations are elevated in the brains and spinal cords of CREAE mice with spasticity, and in line with this observation, spasticity exhibited by CREAE mice can be ameliorated by inhibitors of endocannabinoid membrane transport or enzymic hydrolysis.
Negative_regulation (inhibitors) of membrane in brains associated with endocannabinoid, multiple sclerosis and spasticity
2) Confidence 0.05 Published 2002 Journal Pharmacol. Ther. Section Abstract Doc Link 12182963 Disease Relevance 1.67 Pain Relevance 0.86
Accordingly, the amount of endogenous plasminogen bound to the membrane was diminished in 3-week-old DHCR24?
Negative_regulation (was dimini) of membrane
3) Confidence 0.01 Published 2008 Journal Neurochem Res Section Body Doc Link PMC2758381 Disease Relevance 0 Pain Relevance 0
In these studies, cholesterol-lowering drugs and/or cholesterol-extracting agents were used to reduce cellular and membrane cholesterol levels, a procedure that is likely to affect the functional integrity of involved secretases.
Negative_regulation (reduce) of membrane
4) Confidence 0.01 Published 2008 Journal Neurochem Res Section Body Doc Link PMC2758381 Disease Relevance 0.07 Pain Relevance 0
Patients with ET, however, are reasonably well treated with drugs that reduce membrane excitability.
Negative_regulation (reduce) of membrane associated with tremor
5) Confidence 0.00 Published 2008 Journal J Transl Med Section Body Doc Link PMC2613385 Disease Relevance 1.26 Pain Relevance 0.09

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox