INT104673

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Context Info
Confidence 0.41
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 17
Disease Relevance 4.26
Pain Relevance 5.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

chromosome (Obfc1) nucleus (Obfc1) DNA binding (Obfc1)
Anatomy Link Frequency
neurons 5
neuronal 2
STN 2
pons 1
primary motor cortex 1
Obfc1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 18 100.00 Very High Very High Very High
dopamine receptor 237 99.98 Very High Very High Very High
agonist 202 99.80 Very High Very High Very High
Morphine 9 99.80 Very High Very High Very High
Dopamine 919 99.34 Very High Very High Very High
gABA 207 99.16 Very High Very High Very High
positron emission tomography 57 94.48 High High
Pyramidal cell 3 94.28 High High
Substantia nigra 62 93.32 High High
mu opioid receptor 4 93.12 High High
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 26 99.96 Very High Very High Very High
Disease Progression 5 99.60 Very High Very High Very High
Movement Disorders 21 99.48 Very High Very High Very High
Disease 391 99.26 Very High Very High Very High
Parkinson's Disease 283 98.88 Very High Very High Very High
Wheal 5 93.88 High High
Epilepsy 1 89.40 High High
Dyskinesias 215 85.04 High High
Catalepsy 8 84.08 Quite High
Cognitive Disorder 40 83.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We showed that the pathological activity of STN neurons after severe lesion is not mediated by the GP.
Neg (not) Positive_regulation (mediated) of STN in STN
1) Confidence 0.41 Published 2007 Journal Exp. Neurol. Section Abstract Doc Link 17395181 Disease Relevance 0.37 Pain Relevance 0.17
Moreover, the unchanged activity of GP neurons is likely to be a consequence of the STN hyperactivity.
Positive_regulation (consequence) of STN in neurons associated with attention deficit hyperactivity disorder
2) Confidence 0.41 Published 2007 Journal Exp. Neurol. Section Abstract Doc Link 17395181 Disease Relevance 0.36 Pain Relevance 0.17
One-2 weeks after dopamine cell lesion, firing rate, incidence of bursty and 0.3-2.5 Hz oscillatory activity of neurons and LFP power in the STN all increased significantly.
Positive_regulation (increased) of STN in STN associated with dopamine
3) Confidence 0.36 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17897398 Disease Relevance 0.12 Pain Relevance 0.55
The results demonstrate that prenatal morphine exposure increases the mu-opioid receptor density in the SNC and STN, but not in the SNR or in the SC of gonadally intact adult male rats.
Positive_regulation (increases) of STN in SNR associated with opioid receptor and morphine
4) Confidence 0.05 Published 2002 Journal Brain Res. Bull. Section Abstract Doc Link 12183016 Disease Relevance 0.16 Pain Relevance 0.79
For example, intra-subthalamic infusions of dopamine or of the D1LR agonist SKF38393 activated STN neurons in rats (Mintz et al., 1986; Ni et al., 2001).
Positive_regulation (activated) of STN in neurons associated with dopamine and agonist
5) Confidence 0.02 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0 Pain Relevance 0.48
More recent in vitro brain slice recording studies confirmed that D2LR activation increases STN activity via a reduction of GABA release, and that this may result not only in firing rate changes, but also in a reduction of rebound bursting activities in this nucleus (Baufreton and Bevan, 2008; Johnson, 2008).
Positive_regulation (activation) of STN in brain associated with gaba
6) Confidence 0.02 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0 Pain Relevance 0.42
For example, activation of D2LRs in the STN was shown to reduce GABA-A receptor-mediated currents in STN neurons by reducing GABA release (Shen and Johnson, 2000; Floran et al., 2004).
Positive_regulation (activation) of STN in neurons associated with gaba
7) Confidence 0.01 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0 Pain Relevance 0.44
We have recently carried out preliminary studies indicating that activation of D1LRs or D2LRs in the monkey STN increases the firing rates of STN neurons, and that D1LR activation decreases bursting activities of these neurons (Rommelfanger et al., 2010).
Positive_regulation (activation) of STN in neurons
8) Confidence 0.01 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0 Pain Relevance 0.44
Furthermore, local D1LR activation influenced the discharge patterns of SNr neurons, increasing oscillations in the low frequency ranges (3–15 Hz range of frequencies) and increasing bursting (Kliem et al., 2007a,b), perhaps through the induction of rebound bursts due to GABA-mediated hyperpolarization of SNr cells, as has been demonstrated to occur in GPe and STN (Nambu and Llinas, 1994; Overton and Greenfield, 1995; Beurrier et al., 1999; Bevan et al., 2002; Kass and Mintz, 2006).
Positive_regulation (occur) of STN in neurons associated with gaba
9) Confidence 0.01 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0 Pain Relevance 0.25
Early studies of dopamine receptor activation in the STN suggested that dopamine receptor activation in the STN may act to decrease STN neuronal activity.
Positive_regulation (activation) of STN in neuronal associated with dopamine receptor
10) Confidence 0.01 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0 Pain Relevance 0.38
Early studies of dopamine receptor activation in the STN suggested that dopamine receptor activation in the STN may act to decrease STN neuronal activity.
Positive_regulation (activation) of STN in neuronal associated with dopamine receptor
11) Confidence 0.01 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0 Pain Relevance 0.35
Activation of D1LRs in the STN resulted in orofacial dyskinesias in normal and dopamine-depleted rats (Parry et al., 1994; Mehta et al., 2000).
Positive_regulation (Activation) of STN associated with movement disorders and dopamine
12) Confidence 0.01 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0.18 Pain Relevance 0.34
Of particular interest for this review, they found that the STN showed a dramatic increase in 2-DG uptake in animals exposed to dopamine agonist immediately prior to the terminal procedure, especially in ventromedial “limbic/associative” STN, along with relative greater levels of 2-DG uptake in GPi (Mitchell et al., 1989, 1992).
Positive_regulation (increase) of STN associated with dopamine and agonist
13) Confidence 0.01 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2947938 Disease Relevance 0.38 Pain Relevance 0.17
Parallel to these observations, there are evidences of an increase in mitochondrial respiratory chain enzyme activity in ENT nucleus in the lesioned hemisphere of 6-OHDA rats suggesting increased synaptic activity, perhaps due to increased firing of the STN (Porter et al., 1994).
Positive_regulation (increased) of STN in nucleus
14) Confidence 0.01 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2947938 Disease Relevance 0.34 Pain Relevance 0
“In situ” hybridization of cytochrome oxidase-I (COI) mRNA in the MPTP monkey model of PD has shown increased levels parallel increased firing of the STN (Bergman et al., 1994; Vila et al., 1996; Bezard et al., 1999).
Positive_regulation (increased) of STN associated with parkinson's disease and disease
15) Confidence 0.01 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2947938 Disease Relevance 0.41 Pain Relevance 0
Disease progression is associated with increasing metabolism in the STN and GPi, as well as in the dorsal pons and primary motor cortex.
Positive_regulation (increasing) of STN in primary motor cortex associated with disease progression
16) Confidence 0.01 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2947938 Disease Relevance 0.98 Pain Relevance 0.32
Disease progression is associated with increasing metabolism in the STN and GPi, as well as in the dorsal pons and primary motor cortex.
Positive_regulation (increasing) of STN in pons associated with disease progression
17) Confidence 0.00 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2947938 Disease Relevance 0.98 Pain Relevance 0.32

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