INT104674

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Context Info
Confidence 0.65
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 35
Total Number 36
Disease Relevance 27.76
Pain Relevance 14.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (F2rl1) plasma membrane (F2rl1) signal transducer activity (F2rl1)
Anatomy Link Frequency
cleavage 2
monocyte 2
Visceral 1
smooth muscle 1
knee joint 1
F2rl1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 96 100.00 Very High Very High Very High
agonist 90 100.00 Very High Very High Very High
Nerve growth factor 30 100.00 Very High Very High Very High
bradykinin 8 100.00 Very High Very High Very High
metalloproteinase 2 99.92 Very High Very High Very High
Inflammatory mediators 7 99.88 Very High Very High Very High
Inflammation 317 99.78 Very High Very High Very High
Spontaneous pain 6 99.76 Very High Very High Very High
Hyperalgesia 58 99.74 Very High Very High Very High
allodynia 22 99.34 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 94 100.00 Very High Very High Very High
Pressure And Volume Under Development 41 99.96 Very High Very High Very High
INFLAMMATION 306 99.78 Very High Very High Very High
Pain 118 99.76 Very High Very High Very High
Hyperalgesia 90 99.74 Very High Very High Very High
Pruritus 174 99.68 Very High Very High Very High
Hypersensitivity 196 99.56 Very High Very High Very High
Neuropathic Pain 36 99.34 Very High Very High Very High
Inflammatory Bowel Disease 15 97.70 Very High Very High Very High
Skin Allergy 2 97.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study investigated the effect and mechanism of PAR-2 activation on murine small intestinal smooth muscle function in vitro.
Spec (investigated) Positive_regulation (activation) of PAR-2 in smooth muscle
1) Confidence 0.65 Published 2003 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12801882 Disease Relevance 0 Pain Relevance 0.12
Altogether, the present results indicate that trypsin-induced edema and nociception in the mouse paw represent multi-mediated responses that are largely, but not exclusively, related to the activation of PAR-2.
Positive_regulation (activation) of PAR-2 in paw associated with nociception and pressure and volume under development
2) Confidence 0.62 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18083162 Disease Relevance 0.86 Pain Relevance 0.30
PAR-2 activation did not cause significant joint swelling, but increased IL-1beta concentration which was not influenced by the lack of the TRPV1 channel.
Positive_regulation (activation) of PAR-2 in joint associated with pressure and volume under development
3) Confidence 0.62 Published 2010 Journal Eur J Pain Section Abstract Doc Link 19683949 Disease Relevance 1.57 Pain Relevance 1.02
Protease-activated receptor-2 (PAR-2) is a G-protein-coupled receptor activated through proteolytic cleavage.
Positive_regulation (activated) of PAR-2 in cleavage
4) Confidence 0.62 Published 2010 Journal Eur J Pain Section Abstract Doc Link 19683949 Disease Relevance 0.80 Pain Relevance 0.42
Activation of colonic proteinase-activated receptor-2 (PAR-2) provokes colonic inflammation and increases mucosal permeability in mice.
Positive_regulation (Activation) of PAR-2 associated with inflammation
5) Confidence 0.61 Published 2003 Journal J. Immunol. Section Abstract Doc Link 12682265 Disease Relevance 0.40 Pain Relevance 0.20
The present study aimed to further characterize the inflammatory effect of PAR-2 activation by investigating: 1) the role of NO, 2) the role of afferent neurons, and 3) a possible cause and effect relationship between colonic paracellular permeability changes and mucosal inflammation.
Positive_regulation (activation) of PAR-2 in afferent neurons associated with mucositis and inflammation
6) Confidence 0.61 Published 2003 Journal J. Immunol. Section Abstract Doc Link 12682265 Disease Relevance 0.59 Pain Relevance 0.42
Activation of the peripheral protease-activated receptor-2 (PAR-2) triggers nociceptive behaviour and thermal hyperalgesia in rats.
Positive_regulation (Activation) of PAR-2 associated with nociception and thermal hyperalgesia
7) Confidence 0.58 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12183046 Disease Relevance 0.71 Pain Relevance 0.37
Activation of colonic proteinase-activated receptor-2 (PAR-2) provokes colonic inflammation and increases mucosal permeability in mice.
Positive_regulation (Activation) of proteinase-activated receptor-2 associated with inflammation
8) Confidence 0.53 Published 2003 Journal J. Immunol. Section Abstract Doc Link 12682265 Disease Relevance 0.40 Pain Relevance 0.20
Activation of the peripheral protease-activated receptor-2 (PAR-2) triggers nociceptive behaviour and thermal hyperalgesia in rats.
Positive_regulation (Activation) of peripheral protease-activated receptor-2 associated with nociception and thermal hyperalgesia
9) Confidence 0.51 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12183046 Disease Relevance 0.71 Pain Relevance 0.37
Proteinase-activated receptor-2 (PAR2) activation induces colonic inflammation by an unknown mechanism.
Positive_regulation (activation) of PAR2 associated with inflammation
10) Confidence 0.49 Published 2003 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 14614531 Disease Relevance 0.45 Pain Relevance 0.44
Proteinase-activated receptor-2 (PAR2) activation induces colonic inflammation by an unknown mechanism.
Positive_regulation (activation) of Proteinase-activated receptor-2 associated with inflammation
11) Confidence 0.49 Published 2003 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 14614531 Disease Relevance 0.45 Pain Relevance 0.44
PAR-2 agonists induce contraction of murine small intestine through neurokinin receptors.
Positive_regulation (induce) of PAR-2 in small intestine associated with qutenza and agonist
12) Confidence 0.47 Published 2003 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Title Doc Link 12801882 Disease Relevance 0 Pain Relevance 0.32
These data provide evidence for a significant role of TRPV1 receptors in secondary mechanical hyperalgesia/allodynia and spontaneous pain induced by PAR-2 receptor activation in the knee joint.
Positive_regulation (activation) of PAR-2 receptor in knee joint associated with pain, hyperalgesia, allodynia and spontaneous pain
13) Confidence 0.45 Published 2010 Journal Eur J Pain Section Abstract Doc Link 19683949 Disease Relevance 1.44 Pain Relevance 1.00
Role of N-methyl-D-aspartate receptors and the nitric oxide pathway in nociception/hyperalgesia elicited by protease-activated receptor-2 activation in mice and rats.
Positive_regulation (activation) of protease-activated receptor-2 associated with nociception, hyperalgesia, nociceptor and nmda receptor
14) Confidence 0.42 Published 2002 Journal Neurosci. Lett. Section Title Doc Link 12183046 Disease Relevance 0.80 Pain Relevance 0.74
It has been demonstrated that trypsin is able to evoke the classical signals of inflammation, mainly via the activation of proteinase-activated receptor-2 (PAR-2).
Positive_regulation (activation) of PAR-2 associated with inflammation
15) Confidence 0.42 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18083162 Disease Relevance 0.65 Pain Relevance 0.14
It has been demonstrated that trypsin is able to evoke the classical signals of inflammation, mainly via the activation of proteinase-activated receptor-2 (PAR-2).
Positive_regulation (activation) of proteinase-activated receptor-2 associated with inflammation
16) Confidence 0.42 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18083162 Disease Relevance 0.65 Pain Relevance 0.14
Protease-activated receptor-2 (PAR-2) is a G-protein-coupled receptor activated through proteolytic cleavage.
Positive_regulation (activated) of Protease-activated receptor-2 in cleavage
17) Confidence 0.42 Published 2010 Journal Eur J Pain Section Abstract Doc Link 19683949 Disease Relevance 0.80 Pain Relevance 0.42
Trypsin, released in these conditions, may be responsible for colonic barrier alterations through the activation of PAR2.


Positive_regulation (activation) of PAR2
18) Confidence 0.40 Published 2009 Journal Life Sci. Section Body Doc Link 19345697 Disease Relevance 0 Pain Relevance 0
Although intraplantar PAR-2 activation-induced oedema is also TRPV1 receptor-mediated, primary mechanical hyperalgesia, impaired weight distribution and IL-1beta production are independent of this channel.
Positive_regulation (induced) of PAR-2 associated with pressure and volume under development and hyperalgesia
19) Confidence 0.36 Published 2010 Journal Eur J Pain Section Abstract Doc Link 19683949 Disease Relevance 1.40 Pain Relevance 0.90
Protease-activated receptor-2 peptides activate neurokinin-1 receptors in the mouse isolated trachea.
Positive_regulation (activate) of Protease-activated receptor-2 in trachea
20) Confidence 0.32 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 16434565 Disease Relevance 0 Pain Relevance 0.26

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