INT104678

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Context Info
Confidence 0.34
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 18
Total Number 20
Disease Relevance 6.29
Pain Relevance 3.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ptges) cytoplasm (Ptges)
Anatomy Link Frequency
liver 2
lung 2
microglia 2
chondrocytes 1
dorsal 1
Ptges (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central grey 1 99.58 Very High Very High Very High
Hippocampus 2 99.32 Very High Very High Very High
Inflammation 232 98.36 Very High Very High Very High
Central nervous system 20 97.76 Very High Very High Very High
Spinal cord 11 97.72 Very High Very High Very High
cva 6 96.86 Very High Very High Very High
ischemia 22 92.56 High High
Potency 128 91.52 High High
corticosteroid 8 91.28 High High
Inflammatory response 2 91.12 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 1 99.58 Very High Very High Very High
Fever 244 99.48 Very High Very High Very High
INFLAMMATION 291 98.36 Very High Very High Very High
Arthritis 24 97.04 Very High Very High Very High
Cv General 3 Under Development 6 96.86 Very High Very High Very High
Cv General 2 Under Development 16 96.08 Very High Very High Very High
Brain Hemorrhage 7 93.04 High High
Pressure And Volume Under Development 4 91.44 High High
Disease 20 89.20 High High
Stroke 3 88.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DO induced by cerebral infarction has been proven to be accompanied by an increase in c-fos and zif268 expression in the dorsal pontine tegmentum and periaqueductal gray and mediated by the activation of N-methyl-D-aspartate (NMDA) receptors, cyclooxygenase-2 (COX-2), and prostaglandin E synthase (PGES).
Positive_regulation (activation) of PGES in dorsal associated with cva and central grey
1) Confidence 0.34 Published 2010 Journal Neurourol. Urodyn. Section Abstract Doc Link 20025014 Disease Relevance 0.81 Pain Relevance 0.27
By Western blot analysis, COX-2 and PGEs were induced in total brain, hippocampus, and cortex, but not in the spinal cord.
Neg (not) Positive_regulation (induced) of PGEs in spinal cord associated with hippocampus and spinal cord
2) Confidence 0.32 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12183639 Disease Relevance 0.33 Pain Relevance 0.48
We quantitated mRNA levels for enzymes involved in the prostaglandin biosynthetic pathways and found that both COX-2 and PGE synthase (PGEs) mRNA levels were increased in the brain; no changes were found for expression of COX-1 or PGD synthase mRNA.
Positive_regulation (increased) of PGEs in brain
3) Confidence 0.32 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12183639 Disease Relevance 0.30 Pain Relevance 0.42
The data also indicate that the up-regulation of mPGES-1 contributes to COX-2-mediated PGE(2) production in the CNS during peripheral inflammation.
Positive_regulation (up-regulation) of mPGES-1 in CNS associated with inflammation and central nervous system
4) Confidence 0.27 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15044444 Disease Relevance 0.42 Pain Relevance 0.38
COX-2 and mPGES-1 remained elevated during the late phase, and PGE(2) continued to further increase through 24 h.
Positive_regulation (elevated) of mPGES-1
5) Confidence 0.18 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15044444 Disease Relevance 0.54 Pain Relevance 0.54
, transient overexpression was associated with a negligible induction of PGE2 and mPGES-1 in resting cells (Fig. 5a, b).
Positive_regulation (induction) of mPGES
6) Confidence 0.05 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0.05 Pain Relevance 0.08
Resveratrol effects on mPGES-1 expression seem to be independent on its ability to reduce COX activity/PGE2 formation since other COX inhibitors were unable to modify LPS-induced mPGES-1 upregulation in microglial cells despite their potent inhibitory effects on PGE2 production (Figs. 6 and 7).
Positive_regulation (upregulation) of mPGES-1 in microglial cells
7) Confidence 0.04 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2100038 Disease Relevance 0 Pain Relevance 0
A decrease in PGIS expression, contrasting with an increase in mPGES-1 expression, was also reported in inflamed tissues of rat with adjuvant polyarthritis [32].
Positive_regulation (increase) of mPGES associated with arthritis
8) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0.10 Pain Relevance 0.07
The present study demonstrates an early induction of COX-2 and a delayed induction of mPGES-1 by IL-1?
Positive_regulation (induction) of mPGES
9) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0.31 Pain Relevance 0.28
-induced PGE2 release and mPGES-1 mRNA level by 10 ?
Positive_regulation (induced) of mPGES
10) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0 Pain Relevance 0.10
Under these experimental conditions, COX-2 and mPGES-1 expression was induced from 6 hours, with maximal induction at 12 hours and 24 hours, respectively, after challenge with IL-1?
Positive_regulation (induced) of mPGES
11) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0 Pain Relevance 0.04
As mentioned above, PGES-1 isoforms display distinct functional coupling with upstream COX in cells; cPGES-1 is predominantly coupled with constitutive COX-1, thereby contributing to basal PG synthesis, whereas mPGES-1 is preferentially linked with inducible COX-2 and contributes to stimulated PG synthesis [7].
Positive_regulation (contributes) of mPGES
12) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0.50 Pain Relevance 0.36
was demonstrated to use overlapping, but distinct, signalling pathways to induce COX-2 and mPGES-1, with a major role for ERK1/2 and p38?
Positive_regulation (induce) of mPGES
13) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0.06 Pain Relevance 0.06
activates COX-2 and mPGES-1 sequentially in rat chondrocytes and that the production of large amounts of PGE2 depends mainly on the expression of mPGES-1.
Positive_regulation (activates) of mPGES in chondrocytes
14) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0 Pain Relevance 0.05
Recent evidence indicates that enhanced expression and activity of mPGES-1 is a critical pathological event during inflammation, both in the CNS and in the periphery.
Positive_regulation (activity) of mPGES-1 associated with inflammation
15) Confidence 0.03 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2100038 Disease Relevance 0.75 Pain Relevance 0.26
Since there are significant changes in gene expression in LPS-activated microglia, including a dramatic upregulation of the PGE2 synthesizing enzymes COX-2 and mPGES-1 [31,34,42], we decided to investigate the effects of resveratrol on the expression of these key enzymes responsible for PGE2 production in LPS-stimulated microglia, at both the mRNA and protein levels.
Positive_regulation (upregulation) of mPGES-1 in microglia
16) Confidence 0.03 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2100038 Disease Relevance 0 Pain Relevance 0
Previously, we reported that the onset of the first phase of LPS fever is associated with large increases of COX-2 and mPGES-1 mRNAs in the lung and liver and with a moderate increase of COX-2 (but not mPGES-1) mRNA in the hypothalamus [22].
Positive_regulation (increase) of mPGES-1 in liver associated with fever
17) Confidence 0.01 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1551923 Disease Relevance 0.50 Pain Relevance 0
Previously, we reported that the onset of the first phase of LPS fever is associated with large increases of COX-2 and mPGES-1 mRNAs in the lung and liver and with a moderate increase of COX-2 (but not mPGES-1) mRNA in the hypothalamus [22].
Positive_regulation (increases) of mPGES-1 in liver associated with fever
18) Confidence 0.01 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1551923 Disease Relevance 0.56 Pain Relevance 0
Previously, we reported that the onset of the first phase of LPS fever is associated with large increases of COX-2 and mPGES-1 mRNAs in the lung and liver and with a moderate increase of COX-2 (but not mPGES-1) mRNA in the hypothalamus [22].
Positive_regulation (increase) of mPGES-1 in lung associated with fever
19) Confidence 0.00 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1551923 Disease Relevance 0.50 Pain Relevance 0
Previously, we reported that the onset of the first phase of LPS fever is associated with large increases of COX-2 and mPGES-1 mRNAs in the lung and liver and with a moderate increase of COX-2 (but not mPGES-1) mRNA in the hypothalamus [22].
Positive_regulation (increases) of mPGES-1 in lung associated with fever
20) Confidence 0.00 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1551923 Disease Relevance 0.56 Pain Relevance 0

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