INT104679

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Context Info
Confidence 0.41
First Reported 2002
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 33
Total Number 54
Disease Relevance 10.14
Pain Relevance 7.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ptges) cytoplasm (Ptges)
Anatomy Link Frequency
microglia 11
chondrocytes 3
brain 3
spinal cord 2
articular 1
Ptges (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 1 99.54 Very High Very High Very High
Inflammation 666 99.18 Very High Very High Very High
Spinal cord 41 98.88 Very High Very High Very High
acular 6 98.38 Very High Very High Very High
Inflammatory mediators 45 98.14 Very High Very High Very High
COX-2 inhibitor 46 97.88 Very High Very High Very High
Potency 336 97.72 Very High Very High Very High
aspirin 2 97.44 Very High Very High Very High
Bioavailability 21 95.88 Very High Very High Very High
agonist 441 95.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 801 99.18 Very High Very High Very High
Pleurisy 6 98.28 Very High Very High Very High
Arthritis 63 97.56 Very High Very High Very High
Leukemia 43 97.20 Very High Very High Very High
Fever 139 94.16 High High
Pressure And Volume Under Development 12 92.40 High High
Disease 109 89.80 High High
Stroke 22 88.40 High High
Apoptosis 21 87.56 High High
Injury 88 87.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dexamethasone treatment reduced the expression of both COX-2 and PGEs in kainate-treated animals.
Gene_expression (expression) of PGEs associated with dexamethasone
1) Confidence 0.41 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12183639 Disease Relevance 0.32 Pain Relevance 0.48
The cytosolic PGE(2) synthase (cPGES) showed a small transient increase during the early phase, whereas mPGES-2 expression was not affected by inflammation.
Gene_expression (expression) of mPGES-2 associated with inflammation
2) Confidence 0.31 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15044444 Disease Relevance 0.63 Pain Relevance 0.56
The expression of mPGES-1 was strongly up-regulated in the brain and spinal cord during inflammation, whereas no change was detected for the expression of cPGES, mPGES-2, COX-1, and terminal PGD, TX, or PGI synthases.
Gene_expression (expression) of mPGES-2 in brain associated with inflammation and spinal cord
3) Confidence 0.31 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15044444 Disease Relevance 0.46 Pain Relevance 0.44
The expression of mPGES-1 was strongly up-regulated in the brain and spinal cord during inflammation, whereas no change was detected for the expression of cPGES, mPGES-2, COX-1, and terminal PGD, TX, or PGI synthases.
Gene_expression (expression) of mPGES-1 in brain associated with inflammation and spinal cord
4) Confidence 0.31 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15044444 Disease Relevance 0.47 Pain Relevance 0.46
COX-2 and mPGES-1 remained elevated during the late phase, and PGE(2) continued to further increase through 24 h.
Gene_expression (elevated) of mPGES-1
5) Confidence 0.27 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15044444 Disease Relevance 0.54 Pain Relevance 0.54
The expression of mPGES-1 was strongly up-regulated in the brain and spinal cord during inflammation, whereas no change was detected for the expression of cPGES, mPGES-2, COX-1, and terminal PGD, TX, or PGI synthases.
Gene_expression (expression) of mPGES-1 in spinal cord associated with inflammation and spinal cord
6) Confidence 0.10 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15044444 Disease Relevance 0.47 Pain Relevance 0.46
The expression of mPGES-1 was strongly up-regulated in the brain and spinal cord during inflammation, whereas no change was detected for the expression of cPGES, mPGES-2, COX-1, and terminal PGD, TX, or PGI synthases.
Gene_expression (expression) of mPGES-2 in spinal cord associated with inflammation and spinal cord
7) Confidence 0.10 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15044444 Disease Relevance 0.46 Pain Relevance 0.44
The study of the expression of COX-2 or mPGES-1 and the release of prostaglandins in activated chondrocytes showed that 15d-PGJ2 was strongly inhibitory, whereas the high-affinity PPAR?
Gene_expression (expression) of mPGES in chondrocytes
8) Confidence 0.06 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0.07 Pain Relevance 0.14
Expression of COX-2, mPGES-1 and adiponectin (chosen as a specific PPAR?
Gene_expression (Expression) of mPGES
9) Confidence 0.06 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0.10 Pain Relevance 0.09
However, our results strongly support the contention that mPGES-1 expression is the most limiting step in PGE2 synthesis, consistent with previous experiments with MK-886 [40], a five-lipoxygenase activating protein (FLAP) inhibitor with in vitro inhibitory potency towards mPGES-1 [44].
Gene_expression (expression) of mPGES associated with potency
10) Confidence 0.06 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0.05 Pain Relevance 0.09
and provoked a limited increase in PGE2 level and mPGES-1 expression in resting cells (Fig. 4a, b).
Gene_expression (expression) of mPGES
11) Confidence 0.06 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0 Pain Relevance 0.10
Next, we examined the potential effects of SC-560 and VAS on LPS-mediated mPGES-1 expression, which could help to explain if the effects of resveratrol on the reduction in mPGES-1 were mediated by a COX-1 mechanism.
Gene_expression (expression) of mPGES-1
12) Confidence 0.05 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2100038 Disease Relevance 0.07 Pain Relevance 0.04
This suggests that LPS-induced microglial expression of mPGES-1 proceeds through molecular mechanisms which are different from the ones involved in COX-2 induction, providing for the first time evidence that the expression of mPGES-1 and COX-2 are not always coupled as suggested by other authors [75,76].
Gene_expression (expression) of mPGES-1
13) Confidence 0.05 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2100038 Disease Relevance 0 Pain Relevance 0
At this point we have not yet identified the exact signal transduction pathway involved in resveratrol's effects on mPGES-1 expression.
Gene_expression (expression) of mPGES-1
14) Confidence 0.05 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2100038 Disease Relevance 0.06 Pain Relevance 0.03
It is of great relevance that resveratrol reduced mPGES-1, but not COX-2 expression (Fig. 4).
Gene_expression (expression) of mPGES-1
15) Confidence 0.05 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2100038 Disease Relevance 0 Pain Relevance 0
However, present findings will inspire new investigations in order to elucidate the differential signal transduction pathways responsible for the expression of mPGES-1 and COX-2 in microglia.
Gene_expression (expression) of mPGES-1 in microglia
16) Confidence 0.05 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2100038 Disease Relevance 0.13 Pain Relevance 0.07
An important new observation of the present study is the dramatic reduction in LPS-mediated expression of mPGES-1 in cells treated with resveratrol (Figs. 3 and 4).
Gene_expression (expression) of mPGES-1
17) Confidence 0.05 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2100038 Disease Relevance 0 Pain Relevance 0
To the best of our knowledge, the present study is the first to document the ability of resveratrol to reduce mPGES-1 expression, as shown here in activated microglia.
Gene_expression (expression) of mPGES-1 in microglia
18) Confidence 0.05 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2100038 Disease Relevance 0 Pain Relevance 0
This suggests that LPS-induced microglial expression of mPGES-1 proceeds through molecular mechanisms which are different from the ones involved in COX-2 induction, providing for the first time evidence that the expression of mPGES-1 and COX-2 are not always coupled as suggested by other authors [75,76].
Gene_expression (expression) of mPGES-1
19) Confidence 0.05 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2100038 Disease Relevance 0 Pain Relevance 0
Since previous studies have shown the ability of antioxidants to modify gene expression of pro-inflammatory mediators in activated microglia [31,45], we studied the effects of Trolox C on LPS-induced COX-2 and mPGES-1 expression.
Gene_expression (expression) of mPGES-1 in microglia associated with inflammatory mediators
20) Confidence 0.05 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2100038 Disease Relevance 0.10 Pain Relevance 0.05

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