INT104696

Context Info Confidence 0.09 First Reported 2002 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.68 Pain Relevance 0.92

cell proliferation (CXCL1) signal transduction (CXCL1) extracellular space (CXCL1) extracellular region (CXCL1) intracellular (CXCL1)

Anatomy Link Frequency eosinophils 1 CXCL1 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 27 100.00 Inflammation 17 100.00 fibrosis 15 100.00 chemokine 3 100.00 cINOD 1 25.00 Inflammatory stimuli 2 5.00 withdrawal 1 5.00 endometriosis 1 5.00 Inflammatory response 1 5.00 spinal inflammation 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 20 100.00 Cystic Fibrosis 15 100.00 Adhesions 2 94.08 Diabetes Mellitus 1 86.24 Pseudomonas Infection 1 65.04 Uremia 1 54.28 Apoptosis 6 33.48 Disease 2 25.00 Obesity 22 21.68 Frailty 1 12.40

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

In this work, we demonstrate the increased release of the proinflammatory cytokines after lipopolysaccharide (LPS) stimulation: human interleukin (hIL)-8 in CF and non-CF airway xenografts, and hIL-6 and human growth-related oncogene-alpha (hGRO-alpha), which could be only analyzed in non-CF xenografts.

Localization (release) of growth-related oncogene-alpha associated with fibrosis and cytokine

1) Confidence 0.09 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12183675 Disease Relevance 1.35 Pain Relevance 0.74

Moreover, leptin could also stimulate the chemokinesis of eosinophils and induce the release of inflammatory cytokines IL-1beta and IL-6 and chemokines IL-8, growth-related oncogene-alpha, and MCP-1 [49]. 2.3.

Localization (release) of growth-related oncogene-alpha in eosinophils associated with chemokine, inflammation and cytokine

2) Confidence 0.03 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2846344 Disease Relevance 0.33 Pain Relevance 0.18

General Comments

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