INT1047

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Context Info
Confidence 0.59
First Reported 1975
Last Reported 2010
Negated 6
Speculated 6
Reported most in Abstract
Documents 314
Total Number 320
Disease Relevance 53.71
Pain Relevance 135.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 40
pituitary 20
blood 12
follicle 7
body 5
LH (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 600 100.00 Very High Very High Very High
Morphine 342 100.00 Very High Very High Very High
Dynorphin 60 100.00 Very High Very High Very High
dexamethasone 48 100.00 Very High Very High Very High
noradrenaline 36 100.00 Very High Very High Very High
depression 34 100.00 Very High Very High Very High
antagonist 348 99.98 Very High Very High Very High
opiate 316 99.98 Very High Very High Very High
anesthesia 90 99.98 Very High Very High Very High
Hippocampus 76 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 483 100.00 Very High Very High Very High
Cancer 101 100.00 Very High Very High Very High
Depression 42 100.00 Very High Very High Very High
Hypotension 10 100.00 Very High Very High Very High
Urological Neuroanatomy 106 99.98 Very High Very High Very High
Hypoglycemia 59 99.98 Very High Very High Very High
Schizophrenia 1100 99.96 Very High Very High Very High
Anovulation 5 99.92 Very High Very High Very High
Galactorrhea 82 99.84 Very High Very High Very High
Uremia 27 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ether (1400-2000) and pentobarbital anesthesia decreased the mean serum LH levels at 2000 on proestrus.
Negative_regulation (decreased) of LH associated with anesthesia
1) Confidence 0.59 Published 1994 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 8073435 Disease Relevance 0 Pain Relevance 0.35
Bremazocine, therefore, probably acts mainly through suprapituitary CNS-opiate receptor sites, which indirectly, rather than locally, mediate LH inhibition.
Negative_regulation (inhibition) of LH in CNS associated with opiate and central nervous system
2) Confidence 0.59 Published 1985 Journal J. Endocrinol. Section Abstract Doc Link 4067481 Disease Relevance 0.67 Pain Relevance 0.48
In castrated male rats treated with testosterone propionate (TP), nalmefene (10 mg/kg) reversed the androgen negative feedback on LH secretion; surprisingly, when higher doses (25 and 50 mg/kg) were injected, the compound lost its ability to antagonize the testosterone-induced inhibition of LH levels.
Negative_regulation (inhibition) of LH
3) Confidence 0.59 Published 1985 Journal Steroids Section Abstract Doc Link 3842024 Disease Relevance 0 Pain Relevance 0.66
DSLET produced the same decrease in dopaminergic activity in the LH as in the whole hypothalamus.
Negative_regulation (decrease) of LH in hypothalamus
4) Confidence 0.59 Published 1990 Journal Brain Res. Section Abstract Doc Link 2322848 Disease Relevance 0 Pain Relevance 0.27
Thus, the IC50 values (i.e. the dose required to give 50% reduction in LH levels) for 12, 23 and 33-day old female rats were 0.03, 0.04 and 0.17 mg/kg BW, respectively.
Negative_regulation (reduction) of LH
5) Confidence 0.59 Published 1982 Journal Endocrinology Section Abstract Doc Link 7056220 Disease Relevance 0 Pain Relevance 0.29
When rats were subsequently subjected to restraint for 5 hrs starting at t = -5 min, the restraint-induced inhibition of surge levels of LH was not affected.
Negative_regulation (inhibition) of LH
6) Confidence 0.59 Published 1997 Journal Life Sci. Section Abstract Doc Link 9064478 Disease Relevance 0.22 Pain Relevance 0.55
Restraint stress for 6 hrs starting at t = -1 h (the onset of the LH surge being at t = 0 h) caused a suppression of LH levels (including peak height) during the period of the LH surge.
Negative_regulation (suppression) of LH associated with stress
7) Confidence 0.59 Published 1997 Journal Life Sci. Section Abstract Doc Link 9064478 Disease Relevance 0.27 Pain Relevance 0.41
These results indicate that the rapid decrease of LH levels after Nalt treatment in normal rats is not due to absence of the drug in the system.
Negative_regulation (decrease) of LH
8) Confidence 0.59 Published 1987 Journal Life Sci. Section Abstract Doc Link 3600195 Disease Relevance 0.35 Pain Relevance 0.32
The administration of oestradiol to ovariectomized rats decreased serum LH levels at 13.00 and 18.00 h on day 3.
Negative_regulation (decreased) of serum LH
9) Confidence 0.59 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9300262 Disease Relevance 0 Pain Relevance 0.25
Morphine (mu-agonist), significantly decreased NA concentration and plasma LH levels, but significantly increased dopamine (DA) and serotonin (5-HT) activity.
Negative_regulation (decreased) of LH in plasma associated with dopamine, noradrenaline, agonist, serotonin and morphine
10) Confidence 0.58 Published 1989 Journal J. Neurol. Sci. Section Abstract Doc Link 2559164 Disease Relevance 0 Pain Relevance 1.37
Opiate inhibition of luteinizing hormone (LH) appears to involve changes in hypothalamic monoaminergic activity.
Negative_regulation (inhibition) of LH associated with opiate and monoamine
11) Confidence 0.58 Published 1989 Journal J. Neurol. Sci. Section Abstract Doc Link 2559164 Disease Relevance 0 Pain Relevance 0.97
Cyclazocine, ketocyclazocine and tifluadom (kappa-agonists) increased NA turnover but only tifluadom increased 5-HT turnover, also reducing LH levels significantly.
Negative_regulation (reducing) of LH associated with noradrenaline and agonist
12) Confidence 0.58 Published 1989 Journal J. Neurol. Sci. Section Abstract Doc Link 2559164 Disease Relevance 0 Pain Relevance 1.29
Thus, our demonstration of a maturation-related reduction in opiate inhibition of LH suggests a critical role for endogenous (hypothalamic?)
Negative_regulation (inhibition) of LH associated with opiate
13) Confidence 0.58 Published 1983 Journal Endocrinology Section Abstract Doc Link 6409589 Disease Relevance 0 Pain Relevance 0.48
Even the highest doses of apomorphine did not decrease plasma LH further than to about 100 ng of LH-RP-1/ml.
Neg (not) Negative_regulation (decrease) of LH in plasma
14) Confidence 0.58 Published 1981 Journal Acta Endocrinol. Section Abstract Doc Link 7257697 Disease Relevance 0 Pain Relevance 0.12
Morphine significantly reduced LH levels in prepubertal castrates given testosterone after 60 days of age.
Negative_regulation (reduced) of LH associated with morphine
15) Confidence 0.58 Published 1987 Journal J. Reprod. Fertil. Section Abstract Doc Link 3820180 Disease Relevance 0 Pain Relevance 0.64
In prepubertal castrates, testosterone replacement between Days 26 and 50 of life resulted in responses to morphine similar to those found in rats castrated after puberty, i.e. serum LH levels were not reduced.
Neg (not) Negative_regulation (reduced) of LH associated with morphine
16) Confidence 0.58 Published 1987 Journal J. Reprod. Fertil. Section Abstract Doc Link 3820180 Disease Relevance 0 Pain Relevance 0.59
Injection of estradiol benzoate, together with progesterone, similarly reduced serum LH levels in ovariectomized rats, and this inhibition was partially reversed by naloxone.
Negative_regulation (reduced) of serum LH associated with narcan
17) Confidence 0.58 Published 1982 Journal Neuroendocrinology Section Abstract Doc Link 7041002 Disease Relevance 0 Pain Relevance 0.40
We found that morphine was extremely effective in suppressing serum LH levels in animals that had been castrated for periods of less than 7 days, but was considerably less potent in long-term castrates (13 + days).
Negative_regulation (suppressing) of serum LH associated with morphine
18) Confidence 0.58 Published 1982 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7143239 Disease Relevance 0 Pain Relevance 0.61
Oe-P administration at the age of 14 days induced a significant decrease of LH levels.
Negative_regulation (decrease) of LH
19) Confidence 0.58 Published 1987 Journal Acta Endocrinol. Section Abstract Doc Link 3035852 Disease Relevance 0 Pain Relevance 0.31
Injection of the catecholamine precursor L-dopa (100 mg/kg) can prevent the increase of plasma corticosterone, but not the decrease of LH.
Neg (not) Negative_regulation (decrease) of LH in plasma associated with catecholamine
20) Confidence 0.58 Published 1982 Journal Acta Endocrinol. Section Abstract Doc Link 7113589 Disease Relevance 0.25 Pain Relevance 0.62

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