INT104705

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.28
First Reported 2002
Last Reported 2003
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.10
Pain Relevance 3.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear chromosome (Msh3) nucleus (Msh3) enzyme binding (Msh3)
DNA binding (Msh3)
Anatomy Link Frequency
EM-2 2
paw 1
spinal cord 1
Msh3 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 1 100.00 Very High Very High Very High
Antinociceptive 16 99.98 Very High Very High Very High
Enkephalin 7 99.94 Very High Very High Very High
noradrenaline 1 99.20 Very High Very High Very High
withdrawal 2 99.08 Very High Very High Very High
Morphine 4 99.02 Very High Very High Very High
MU agonist 2 98.84 Very High Very High Very High
antinociception 17 97.98 Very High Very High Very High
tail-flick 6 97.60 Very High Very High Very High
intrathecal 2 96.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 1 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of pretreatment with endomorphin-1 (EM-1) or endomorphin-2 (EM-2) given intrathecally (i.t.) on the tail-flick inhibition induced by subsequent i.t. injection of EM-1 or EM-2 was studied in CD-1 mice.
Regulation (effect) of EM-1 in EM-2 associated with tail-flick
1) Confidence 0.28 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12932813 Disease Relevance 0 Pain Relevance 0.27
Like other mu-opioid agonists morphine and DAMGO ([D-Ala2,NMePhe4,Gly5-ol]enkephalin), EM-1 and EM-2 given i.c.v. activate descending pain controls by the releases of noradrenaline and 5-HT and subsequently act on alpha2-adrenoceptors and 5-HT receptors, respectively, in the spinal cord to produce antinociception.
Regulation (controls) of EM-1 in spinal cord associated with antinociception, pain, mu agonist, noradrenaline, enkephalin, spinal cord and morphine
2) Confidence 0.18 Published 2002 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 12184724 Disease Relevance 0.10 Pain Relevance 1.34
Experiments were designed to determine the involvement of subtypes of MOP-R on the antinociceptive effects of EM-1 or EM-2 using the paw withdrawal test.
Regulation (effects) of EM-1 in paw associated with withdrawal and antinociceptive
3) Confidence 0.16 Published 2002 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 12184725 Disease Relevance 0 Pain Relevance 0.70
EM-2-induced antinociception was attenuated by pretreatment with s.c. nor-binaltorphimine and naltrindole, whereas the effect of EM-1 was not affected.
Neg (not) Regulation (affected) of EM-1 in EM-2 associated with antinociception
4) Confidence 0.09 Published 2002 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 12184725 Disease Relevance 0 Pain Relevance 1.21

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox