INT104708

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Context Info
Confidence 0.72
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 12
Disease Relevance 0.07
Pain Relevance 3.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear chromosome (Msh3) nucleus (Msh3) enzyme binding (Msh3)
DNA binding (Msh3)
Anatomy Link Frequency
EM-2 5
neurons 2
Msh3 (Mus musculus)
Pain Link Frequency Relevance Heat
antinociception 17 99.96 Very High Very High Very High
intrathecal 2 99.58 Very High Very High Very High
mu opioid receptor 3 98.60 Very High Very High Very High
withdrawal 1 98.28 Very High Very High Very High
Antinociceptive 9 98.08 Very High Very High Very High
tail-flick 7 95.76 Very High Very High Very High
Opioid 4 94.00 High High
opioid receptor 7 92.04 High High
narcan 3 91.28 High High
antagonist 6 88.48 High High
Disease Link Frequency Relevance Heat
Pain 9 74.24 Quite High
Disease 385 47.08 Quite Low
Targeted Disruption 70 46.56 Quite Low
Spinocerebellar Ataxia Type 2 28 5.00 Very Low Very Low Very Low
Obesity 14 5.00 Very Low Very Low Very Low
Frailty 14 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 7 5.00 Very Low Very Low Very Low
Syndrome 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together with the lack of correlation between instability index and Msh3 expression levels across 16 tissues (Figure 6A, Additional file 2), the data argue against a major role for Msh3 expression levels in determining tissue- or cell type-specific instability.
Gene_expression (expression) of Msh3
1) Confidence 0.72 Published 2010 Journal BMC Syst Biol Section Body Doc Link PMC2856555 Disease Relevance 0 Pain Relevance 0
To probe these processes further, we examined whether expression levels of specific DNA repair genes (Msh2, Msh3, Ogg1 and Cbp), previously shown to play important roles in CAG repeat instability [8,13,14,21,24-26], correlated with instability index measured in 16 tissues.
Spec (whether) Gene_expression (expression) of Msh3
2) Confidence 0.72 Published 2010 Journal BMC Syst Biol Section Body Doc Link PMC2856555 Disease Relevance 0 Pain Relevance 0
Selective neuronal expression of Msh3 was recently proposed to contribute to the greater levels of instability in neurons compared to glia [24], and therefore we explored this further.
Gene_expression (expression) of Msh3 in neurons
3) Confidence 0.72 Published 2010 Journal BMC Syst Biol Section Body Doc Link PMC2856555 Disease Relevance 0 Pain Relevance 0
Analyses of gene expression data revealed nearly identical Msh3 expression levels in purified neurons and glia (Figure 6C).
Gene_expression (expression) of Msh3 in neurons
4) Confidence 0.72 Published 2010 Journal BMC Syst Biol Section Body Doc Link PMC2856555 Disease Relevance 0 Pain Relevance 0
Together with the lack of correlation between instability index and Msh3 expression levels across 16 tissues (Figure 6A, Additional file 2), the data argue against a major role for Msh3 expression levels in determining tissue- or cell type-specific instability.
Gene_expression (expression) of Msh3
5) Confidence 0.72 Published 2010 Journal BMC Syst Biol Section Body Doc Link PMC2856555 Disease Relevance 0 Pain Relevance 0
The expression levels of Msh3, Ogg1 and Cbp did not correlate with instability index and Msh2 expression level showed a weak negative correlation with instability index (Figure 6A, Additional file 2).
Gene_expression (expression) of Msh3
6) Confidence 0.72 Published 2010 Journal BMC Syst Biol Section Body Doc Link PMC2856555 Disease Relevance 0 Pain Relevance 0
The expression levels of Msh3, Ogg1 and Cbp did not correlate with instability index and Msh2 expression level showed a weak negative correlation with instability index (Figure 6A, Additional file 2).
Gene_expression (levels) of Msh3
7) Confidence 0.56 Published 2010 Journal BMC Syst Biol Section Body Doc Link PMC2856555 Disease Relevance 0 Pain Relevance 0
EM-1 or EM-2 given i.c.v. or i.t. dose-dependently produce antinociception.
Gene_expression (produce) of EM-1 in EM-2 associated with antinociception
8) Confidence 0.26 Published 2002 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 12184724 Disease Relevance 0.07 Pain Relevance 0.96
In the present study, it was found that intraperitoneal (i.p.) pre-injection of N(G)-nitro-L-arginine methyl ester (L-NAME) significantly influenced the endomorphin-1 (EM-1) and endomorphin-2 (EM-2) induced antinociception.
Gene_expression (influenced) of EM-1 in EM-2 associated with antinociception
9) Confidence 0.24 Published 2006 Journal Protein Pept. Lett. Section Abstract Doc Link 17168821 Disease Relevance 0 Pain Relevance 0.34
The intrathecal (i.t.) injection of EM-1 and EM-2 produced dose-dependent antinociception in mice 1 min after the injection.
Gene_expression (produced) of EM-1 in EM-2 associated with antinociception and intrathecal
10) Confidence 0.23 Published 2002 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 12184725 Disease Relevance 0 Pain Relevance 0.79
We have previously demonstrated that both endomorphin-1 (EM-1) and endomorphin-2 (EM-2) at high doses (1.75-35 nmol) given intrathecally (i.t.) or intracerebroventricularly produce antinociception by stimulation of mu-opioid receptors.
Gene_expression (produce) of EM-1 in EM-2 associated with antinociception and mu opioid receptor
11) Confidence 0.18 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14557378 Disease Relevance 0 Pain Relevance 0.93
A series of endomorphin-1 (EM-1) and endomorphin-2 (EM-2) analogues, containing non-cyclic amino acids (Ala, D-Ala, beta-Ala, NMeAla, D-NMeAla or Sar) instead of Pro in position 2 was synthesized, where NMeAla = N-methylalanine and Sar = N-methylglycine, sarcosine.
Gene_expression (synthesized) of EM-1 in EM-2
12) Confidence 0.04 Published 2010 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 19874287 Disease Relevance 0 Pain Relevance 0.14

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