INT104709

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Context Info
Confidence 0.01
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.07
Pain Relevance 1.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Msh3, Rbm39) nuclear chromosome (Msh3) mRNA processing (Rbm39)
RNA binding (Rbm39) enzyme binding (Msh3) DNA binding (Msh3)
Anatomy Link Frequency
EM-2 1
Msh3 (Mus musculus)
Rbm39 (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 2 100.00 Very High Very High Very High
MU agonist 2 99.20 Very High Very High Very High
antinociception 6 98.92 Very High Very High Very High
Morphine 2 98.56 Very High Very High Very High
Opioid 1 96.72 Very High Very High Very High
Dynorphin 2 93.88 High High
Spinal cord 2 93.80 High High
opioid receptor 3 93.04 High High
Enkephalin 3 92.84 High High
Kappa opioid receptor 2 84.56 Quite High
Disease Link Frequency Relevance Heat
Pain 1 69.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One subtype of mu-opioid receptors is stimulated by EM-1, EM-2 and other mu-opioid agonists morphine and DAMGO; and another subtype of mu-opioid is sorely stimulated by EM-2 and is involved in the releases of dynorphin A(1-17) and Met-enkephalin for the production of antinociception.
EM-1 Positive_regulation (stimulated) of receptors in EM-2 associated with antinociception, mu agonist, dynorphin, mu opioid receptor, enkephalin, opioid and morphine
1) Confidence 0.01 Published 2002 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 12184724 Disease Relevance 0.07 Pain Relevance 1.76

General Comments

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