INT104731

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Context Info
Confidence 0.67
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 9.22
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NEFL)
Anatomy Link Frequency
cerebrospinal fluid 1
brain 1
ganglion cells 1
neural 1
neurons 1
NEFL (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 9 99.84 Very High Very High Very High
Inflammation 39 98.08 Very High Very High Very High
cva 53 97.00 Very High Very High Very High
backache 12 96.56 Very High Very High Very High
intrathecal 4 96.52 Very High Very High Very High
headache 10 96.04 Very High Very High Very High
medulla 4 95.84 Very High Very High Very High
rheumatoid arthritis 1 89.04 High High
Pain 89 88.56 High High
Sciatica 3 83.96 Quite High
Disease Link Frequency Relevance Heat
Lyme Neuroborreliosis 159 99.84 Very High Very High Very High
Atherosclerosis 34 99.84 Very High Very High Very High
Demyelinating Disease 9 99.84 Very High Very High Very High
Intervertebral Disk Displacement 1 99.50 Very High Very High Very High
Ganglion Cysts 37 99.48 Very High Very High Very High
Oligodendroglioma 57 99.12 Very High Very High Very High
Disease 87 98.36 Very High Very High Very High
Urological Neuroanatomy 1 98.36 Very High Very High Very High
INFLAMMATION 40 98.08 Very High Very High Very High
Cv General 4 Under Development 42 97.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In six of seven brain-injured piglets, accumulation of the 68-kDa neurofilament protein was evident in contiguous axons (swollen) and occasionally in disconnected axons (axonal bulbs), suggestive of traumatic axonal injury (TAI).
Positive_regulation (accumulation) of 68-kDa neurofilament protein in brain associated with injury
1) Confidence 0.67 Published 2002 Journal J. Neurotrauma Section Abstract Doc Link 12184854 Disease Relevance 1.25 Pain Relevance 0.22
Regarding markers of neural damage and tau pathology, we confirm earlier findings of increased CSF NFL in some LNB patients, which indicates acute damage to large myelinated axons [23].
Positive_regulation (increased) of NFL in neural associated with lyme neuroborreliosis
2) Confidence 0.49 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2902447 Disease Relevance 1.04 Pain Relevance 0.15
CSF NFL, which is increased following damage to large myelinated axon, was analyzed using an ELISA, as previously described [11].
Positive_regulation (increased) of NFL
3) Confidence 0.45 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2902447 Disease Relevance 0.05 Pain Relevance 0.03
We also confirm previous findings of elevated CSF NFL in LNB, suggesting damage to myelinated axons.
Positive_regulation (elevated) of NFL associated with lyme neuroborreliosis
4) Confidence 0.45 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2902447 Disease Relevance 1.36 Pain Relevance 0.12
We found that serum anti-NF-L IgG antibodies were significantly elevated in MS patients with primary progressive disease course and we provide evidence for an intrathecal production of these antibodies.
Positive_regulation (elevated) of NF-L associated with multiple sclerosis, disease and intrathecal
5) Confidence 0.35 Published 2004 Journal Mult. Scler. Section Abstract Doc Link 15584481 Disease Relevance 1.53 Pain Relevance 0.54
Low molecular weight neurofilament protein (NF-L), found in young immature neurons, increased considerably after 2 weeks of bFGF treatment and expression of mature NF forms, NF-M and NF-H, appeared after bFGF treatment.
Positive_regulation (increased) of Low molecular weight neurofilament protein in neurons
6) Confidence 0.18 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2092394 Disease Relevance 0.11 Pain Relevance 0
Unlike neurofilament protein, peripherin mRNA also increases after axotomy [21], a finding consistent with the abovementioned possibility of an increased rate of synthesis of cytoskeletal proteins in our study.
Positive_regulation (increases) of neurofilament protein
7) Confidence 0.14 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1079867 Disease Relevance 0.13 Pain Relevance 0
We have previously shown that axotomy increases the content of tubulin and neurofilament protein in the injured cell body, but decreases their content in the axon proximal to the injury site [10].
Positive_regulation (increases) of neurofilament protein in proximal associated with injury
8) Confidence 0.14 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1079867 Disease Relevance 0.17 Pain Relevance 0
The M2 receptor was localized to the outer segments of the photoreceptor layer, OPL, IPL, and the nerve fiber layer (NFL) while the M3 receptor exhibited a quite distinctive expression in the OPL and NFL with processes extending through the INL and terminating at the IPL, which may be consistent with Müller cell expression.
Positive_regulation (segments) of NFL in nerve
9) Confidence 0.07 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2649308 Disease Relevance 0.10 Pain Relevance 0
Laboratory findings like higher levels of neurofilament protein in the cerebrospinal fluid before surgery does also correlate to post-operative sequelae [34].
Positive_regulation (levels) of neurofilament protein in cerebrospinal fluid
10) Confidence 0.07 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2944219 Disease Relevance 0.18 Pain Relevance 0.08
Patients with herniated discs have been found to have increased concentrations of neurofilament protein and S-100 in cerebrospinal fluid (indicating possible damage of axons and Schwann cells in nerve roots) (Brisby et al. 1999); however, it is unlikely that cerebrospinal fluid sampling would be a useful biomarker in the general population.


Positive_regulation (increased) of neurofilament protein in Schwann cells associated with intervertebral disk displacement
11) Confidence 0.06 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716792 Disease Relevance 0.55 Pain Relevance 0.10
The dysmorphic ganglion cells were also variably immunoreactive for neurofilament protein and Neu-N, while the oligodendroglioma cells were negative.
Positive_regulation (immunoreactive) of neurofilament protein in ganglion cells associated with ganglion cysts and oligodendroglioma
12) Confidence 0.04 Published 2010 Journal Acta Neuropathol Section Body Doc Link PMC2892612 Disease Relevance 1.30 Pain Relevance 0
Using a proteomic approach, You et al. found that the levels of ferritin light chain protein were significantly increased in atherosclerotic coronary arteries [48].
Positive_regulation (increased) of chain protein associated with atherosclerosis
13) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736586 Disease Relevance 1.44 Pain Relevance 0.12

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