INT104733

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 2002
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 24
Total Number 27
Disease Relevance 43.87
Pain Relevance 2.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ren1) extracellular space (Ren1) extracellular region (Ren1)
intracellular (Ren1) response to stress (Ren1)
Anatomy Link Frequency
blood 4
endothelial cells 4
vascular system 2
blood vessel endothelial cells 2
kidney 2
Ren1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 321 100.00 Very High Very High Very High
cytokine 289 100.00 Very High Very High Very High
cOX1 5 99.60 Very High Very High Very High
COX2 5 99.60 Very High Very High Very High
cINOD 5 95.76 Very High Very High Very High
COX-2 inhibitor 5 88.72 High High
fibrosis 27 83.56 Quite High
Inflammatory response 37 63.00 Quite High
substance P 1 44.72 Quite Low
bradykinin 3 44.08 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 361 100.00 Very High Very High Very High
Cytomegalovirus Infection 3456 99.98 Very High Very High Very High
Infection 2484 99.98 Very High Very High Very High
Chronic Renal Failure 128 99.88 Very High Very High Very High
Pressure And Volume Under Development 1065 99.64 Very High Very High Very High
Hypertension 4 98.92 Very High Very High Very High
Weight Gain 54 98.80 Very High Very High Very High
Sprains And Strains 90 98.28 Very High Very High Very High
Acute Decompensated Heart Failure (ADHF) 4 95.64 Very High Very High Very High
Atherosclerosis 538 95.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The authors studied homozygous Ren-2 rats that overexpress the murine Ren-2d renin gene, resulting in severe hypertension with end-organ damage [21, 22].
Positive_regulation (overexpress) of Gene_expression (overexpress) of renin associated with hypertension
1) Confidence 0.67 Published 2010 Journal Curr Heart Fail Rep Section Body Doc Link PMC2831188 Disease Relevance 0.46 Pain Relevance 0
Prostaglandins that increase renin production in response to ACE inhibition are not derived from cyclooxygenase-1.
Positive_regulation (increase) of Gene_expression (production) of renin associated with cox1
2) Confidence 0.47 Published 2002 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Title Doc Link 12184998 Disease Relevance 0.10 Pain Relevance 0.20
The current study examined further whether COX-1 is also involved in mediating ACEI-induced renin production.
Spec (whether) Positive_regulation (mediating) of Gene_expression (production) of renin
3) Confidence 0.47 Published 2002 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 12184998 Disease Relevance 0.09 Pain Relevance 0.09
Therefore, we investigated if genetic deletion of COX-1 or EP(2) prevents increased ACEI-induced renin expression.
Positive_regulation (induced) of Gene_expression (expression) of renin
4) Confidence 0.47 Published 2002 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 12184998 Disease Relevance 0.07 Pain Relevance 0.07
Therefore, we investigated if genetic deletion of COX-1 or EP(2) prevents increased ACEI-induced renin expression.
Spec (investigated) Positive_regulation (increased) of Gene_expression (expression) of renin
5) Confidence 0.47 Published 2002 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 12184998 Disease Relevance 0.07 Pain Relevance 0.08
We find that the induced renin expression occurred in MCMV infected cells only, and the MCMV antigens were co-localized with renin in the infected cells that were detected by antibodies specific to MCMV and renin, respectively (Fig. 4E–G).
Positive_regulation (induced) of Gene_expression (expression) of renin associated with cytomegalovirus infection
6) Confidence 0.45 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 2.25 Pain Relevance 0
Consistent with the findings of the mouse trial, human CMV (HCMV) infection of blood vessel endothelial cells (EC) induced renin expression in a non-lytic infection manner.
Positive_regulation (induced) of Gene_expression (expression) of renin in blood vessel endothelial cells associated with cytomegalovirus infection and infection
7) Confidence 0.45 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2673691 Disease Relevance 2.44 Pain Relevance 0.07
MCMV infection stimulated renin expression in cells in a MCMV infection dose dependent manner (Fig. 4A–D).
Positive_regulation (stimulated) of Gene_expression (expression) of renin associated with cytomegalovirus infection and infection
8) Confidence 0.45 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 2.45 Pain Relevance 0.16
MCMV infection stimulates expression of renin
Positive_regulation (stimulates) of Gene_expression (expression) of renin associated with cytomegalovirus infection and infection
9) Confidence 0.45 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 2.22 Pain Relevance 0.51
Specifically, we have identified that CMV infection induced expression of renin in an infection dose responsive manner in mouse renal cells and in human vascular endothelial cells.
Positive_regulation (induced) of Gene_expression (expression) of renin in endothelial cells associated with cytomegalovirus infection and infection
10) Confidence 0.45 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 3.16 Pain Relevance 0.15
When UV-inactivated MCMV was employed as a control in the infection, no increase in renin expression was detected (data not shown).


Positive_regulation (increase) of Gene_expression (expression) of renin associated with cytomegalovirus infection and infection
11) Confidence 0.45 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 2.34 Pain Relevance 0
To further define the relationship between MCMV infection and expression of renin, we performed a co-staining assay to measure MCMV infection inducing expression of renin at a single cell level.
Positive_regulation (inducing) of Gene_expression (expression) of renin associated with cytomegalovirus infection and infection
12) Confidence 0.45 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 2.31 Pain Relevance 0.05
HCMV infection stimulates renin expression in vascular endothelial cells (EC)
Positive_regulation (stimulates) of Gene_expression (expression) of renin in endothelial cells associated with cytomegalovirus infection and infection
13) Confidence 0.45 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 2.05 Pain Relevance 0.10
We determined renin expression in both mouse and human cells after CMV infection, and find that CMV infection increased renin expression in cells in a MOI dependent manner (Fig. 4, Fig. 7).
Positive_regulation (increased) of Gene_expression (expression) of renin associated with cytomegalovirus infection and infection
14) Confidence 0.45 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 2.18 Pain Relevance 0
To define whether MCMV infection increased expression of renin, we conducted an in vitro study by using As4.1 cells.
Positive_regulation (increased) of Gene_expression (expression) of renin associated with cytomegalovirus infection and infection
15) Confidence 0.45 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 2.26 Pain Relevance 0.31
Co-staining and immunofluorescent microscopy analyses showed that MCMV infection stimulated renin expression at a single cell level.
Positive_regulation (stimulated) of Gene_expression (expression) of renin associated with cytomegalovirus infection and infection
16) Confidence 0.45 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2673691 Disease Relevance 2.34 Pain Relevance 0.09
These results suggest that CMV infection induced renin and Ang II expression, and this underlies a molecular mechanism by which CMV infection causes an increase of blood pressure.


Positive_regulation (induced) of Gene_expression (expression) of renin in blood associated with pressure and volume under development, cytomegalovirus infection and infection
17) Confidence 0.45 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 2.29 Pain Relevance 0.04
However, the in vivo effects of (pro)renin receptor overexpression on end organ damage in experimental animals are mixed and therefore the role of this receptor in chronic kidney disease remains to be determined [32].


Positive_regulation (overexpression) of Gene_expression (overexpression) of renin in kidney associated with chronic renal failure
18) Confidence 0.38 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.79 Pain Relevance 0.04
ACEI also increased renin mRNA expression (+/+ 2.4 +/- 0.2; -/- 2.1 +/- 0.2 fold control; n = 6-10; P < 0.05).
Positive_regulation (increased) of Gene_expression (expression) of renin
19) Confidence 0.34 Published 2002 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 12184998 Disease Relevance 0 Pain Relevance 0.04
Thus, CMV infection did not contribute to the mouse weight gain, but caused an increase of blood pressure apparently via a change in expression of cellular genes, the over expression of inflammatory cytokines, renin and Ang II in the vascular system.
Positive_regulation (change) of Gene_expression (expression) of renin in vascular system associated with pressure and volume under development, inflammation, cytomegalovirus infection, weight gain, infection and cytokine
20) Confidence 0.33 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 2.07 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox