INT104734

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Context Info
Confidence 0.34
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.90
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ren1) extracellular space (Ren1) extracellular region (Ren1)
intracellular (Ren1) response to stress (Ren1)
Ren1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 1 99.98 Very High Very High Very High
withdrawal 4 89.72 High High
antagonist 10 75.60 Quite High
beta blocker 2 55.16 Quite High
COX2 1 25.00 Low Low
COX-2 inhibitor 1 25.00 Low Low
cOX1 1 25.00 Low Low
Inflammation 6 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
headache 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 5 99.86 Very High Very High Very High
Chronic Renal Failure 128 99.64 Very High Very High Very High
Diabetes Mellitus 56 98.72 Very High Very High Very High
Cv Unclassified Under Development 36 95.12 Very High Very High Very High
Hypertension 2 88.32 High High
Death 12 87.68 High High
Proteinuria 42 74.56 Quite High
Renal Disease 46 68.12 Quite High
Myocardial Infarction 4 51.76 Quite High
Disease 16 43.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is well known that nonselective, nonsteroidal anti-inflammatory drugs inhibit renal renin production.
Negative_regulation (inhibit) of Gene_expression (production) of renal renin associated with inflammation and cinod
1) Confidence 0.34 Published 2002 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 12184998 Disease Relevance 0.10 Pain Relevance 0.10
However, in addition to inhibiting the formation of Ang I by the circulating and intrarenal RAAS [77], aliskiren has also been shown to reduce the renal expression of the (pro)renin receptor in an animal model of diabetes [76].
Negative_regulation (reduce) of Gene_expression (expression) of renin associated with diabetes mellitus
2) Confidence 0.32 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.58 Pain Relevance 0.07
Optimizing renin-angiotensin-aldosterone system blockade
Negative_regulation (Optimizing) of Gene_expression (blockade) of renin-angiotensin-aldosterone system
3) Confidence 0.21 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 1.22 Pain Relevance 0.04

General Comments

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