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Context Info
Confidence 0.05
First Reported 2002
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.07
Pain Relevance 1.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein modification process (G2e3) Golgi apparatus (G2e3) intracellular (G2e3)
cytoplasm (G2e3)
Anatomy Link Frequency
Liver 2
G2e3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 14 100.00 Very High Very High Very High
Opioid 2 97.88 Very High Very High Very High
Analgesic 1 84.72 Quite High
mu opioid receptor 3 81.44 Quite High
agonist 2 79.44 Quite High
antagonist 1 78.48 Quite High
methadone 1 70.72 Quite High
Pain 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Cancer 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BACKGROUND: Liver metabolism of morphine leads to the formation of morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G), the latter possessing strong opioid activity that however differs from that of the parent compound.
Positive_regulation (leads) of M3G Binding (formation) of in Liver associated with opioid and morphine
1) Confidence 0.05 Published 2008 Journal Drug Alcohol Depend Section Abstract Doc Link 18597954 Disease Relevance 0 Pain Relevance 1.00
Studies in rats have indicated that UGT1A1 may also contribute to the formation of morphine 3-glucuronide (M3G).
Spec (may) Positive_regulation (contribute) of M3G Binding (formation) of associated with morphine
2) Confidence 0.00 Published 2002 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 12185559 Disease Relevance 0.07 Pain Relevance 0.77

General Comments

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