INT104756

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Context Info
Confidence 0.58
First Reported 2001
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 8.76
Pain Relevance 1.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (ACSM3) molecular_function (ACSM3) cellular_component (ACSM3)
ligase activity (ACSM3) lipid metabolic process (ACSM3)
Anatomy Link Frequency
midline 1
ACSM3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 166 100.00 Very High Very High Very High
Catechol-O-methyltransferase 109 98.04 Very High Very High Very High
cINOD 22 95.88 Very High Very High Very High
aspirin 10 89.36 High High
ischemia 6 87.52 High High
Glutamate 1 85.28 High High
Inflammation 4 83.00 Quite High
headache 4 80.16 Quite High
Trigeminal neuralgia 3 78.24 Quite High
imagery 18 71.60 Quite High
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 118 100.00 Very High Very High Very High
Aneurism 176 99.96 Very High Very High Very High
Head Trauma 12 99.44 Very High Very High Very High
Increased Venous Pressure Under Development 40 98.84 Very High Very High Very High
Cancer 17 98.28 Very High Very High Very High
Infarction 5 97.84 Very High Very High Very High
Cardiovascular Disease 2 97.40 Very High Very High Very High
Neurodegenerative Disease 2 96.44 Very High Very High Very High
Pressure Volume 2 Under Development 2 96.20 Very High Very High Very High
Cerebral Aneurysm 29 96.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the CT scan revealed a thick left SDH with marked midline shift, SAH was absent.
Neg (absent) Gene_expression (absent) of SAH in midline associated with head trauma and cva
1) Confidence 0.58 Published 2002 Journal No Shinkei Geka Section Abstract Doc Link 12187732 Disease Relevance 1.90 Pain Relevance 0.26
This negative finding is entirely consistent with the result of a recent larger scale multicenter study (n=527) which was performed in East-Asian population that presented with SAH (31).
Gene_expression (presented) of SAH associated with cva
2) Confidence 0.50 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2722006 Disease Relevance 0.80 Pain Relevance 0.12
The majority of patients presented with SAH and 42% of patients also had aneurysms at other locations.
Gene_expression (presented) of SAH associated with aneurism and cva
3) Confidence 0.29 Published 2007 Journal Neuroradiology Section Body Doc Link PMC2039855 Disease Relevance 1.50 Pain Relevance 0.20
Possible predictors include the status of the aneurysm (previous history of SAH vs. unruptured only), size of the aneurysm (?
Gene_expression (previous) of SAH associated with aneurism and cva
4) Confidence 0.26 Published 2008 Journal Trials Section Body Doc Link PMC2526062 Disease Relevance 0.73 Pain Relevance 0.12
Homocysteine is a precursor for the biosynthesis of S-adenosyl-L-homocysteine (SAH) which is a strong, noncompetitive inhibitor of COMT.
Gene_expression (biosynthesis) of SAH associated with catechol-o-methyltransferase
5) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664927 Disease Relevance 0.85 Pain Relevance 0.28
The reduction of CBF progresses in many patients within 14 days after SAH.
Gene_expression (progresses) of SAH associated with cva
6) Confidence 0.08 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350130 Disease Relevance 1.38 Pain Relevance 0.40
They assumed that a large amount of NO might be produced by an inducible isoform of NO synthase (iNOS) after SAH and that this might prevent vasospasm or might have a suppressive effect [15,16].
Gene_expression (produced) of SAH associated with cva and increased venous pressure under development
7) Confidence 0.05 Published 2001 Journal Crit Care Section Body Doc Link PMC29055 Disease Relevance 1.16 Pain Relevance 0.15
Manlio Bolla, one of the authors of the paper, is an employee of NicOx SA, the company that produces the compound (NCX 4040) used in the study

Authors' contributions

Gene_expression (produces) of NicOx SA
8) Confidence 0.01 Published 2007 Journal J Transl Med Section Body Doc Link PMC2174440 Disease Relevance 0.43 Pain Relevance 0.29

General Comments

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