INT10476

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Context Info
Confidence 0.36
First Reported 1987
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 26
Total Number 29
Disease Relevance 7.69
Pain Relevance 3.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ALOX5) nuclear envelope (ALOX5) small molecule metabolic process (ALOX5)
oxidoreductase activity (ALOX5) nucleus (ALOX5) cytoplasm (ALOX5)
Anatomy Link Frequency
internal 2
platelet 1
dentition 1
ALOX5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory mediators 4 99.28 Very High Very High Very High
Inflammation 160 98.90 Very High Very High Very High
licofelone 9 98.66 Very High Very High Very High
cINOD 24 96.54 Very High Very High Very High
addiction 122 92.08 High High
aspirin 40 91.68 High High
qutenza 4 86.00 High High
antagonist 19 82.96 Quite High
COX-2 inhibitor 6 82.32 Quite High
Osteoarthritis 89 81.36 Quite High
Disease Link Frequency Relevance Heat
Atherosclerosis 344 99.28 Very High Very High Very High
INFLAMMATION 177 99.20 Very High Very High Very High
Adenoma 2 98.52 Very High Very High Very High
Recurrence 14 98.24 Very High Very High Very High
Calcification 96 98.12 Very High Very High Very High
Disease 78 97.72 Very High Very High Very High
Hyperplasia 1 97.72 Very High Very High Very High
Polyps 4 97.20 Very High Very High Very High
Diabetes Mellitus 232 96.72 Very High Very High Very High
Colorectal Cancer 1 95.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We examined whether 5-lipoxygenase (5-LO), the key enzyme involved in biosynthesis of leukotrienes is a possible target for the spices.
5-lipoxygenase Binding (target) of
1) Confidence 0.36 Published 2004 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 15120715 Disease Relevance 0 Pain Relevance 0.14
Based on that background two different approaches were pursued in the search for GI sparing NSAIDs: a) modification of classical NSAIDs by associating them with phospholipids, cyclodextrins, or chemical moieties that release gastroprotective mediators and b) defining novel targets as well as developing new compounds like dual COX/5-LO or mPGES-1 inhibitors.
5-LO Binding (compounds) of associated with cinod
2) Confidence 0.36 Published 2009 Journal Curr. Med. Chem. Section Abstract Doc Link 19519380 Disease Relevance 0.44 Pain Relevance 0.80
These two SNPs bound the ALOX5 marginally associated SNP (rs2115819, intron 3).
ALOX5 Binding (bound) of
3) Confidence 0.35 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2878676 Disease Relevance 0 Pain Relevance 0
In exploratory analyses, one ALOX5 SNP (rs3780906 in intron 6) was marginally associated (P = .090) with IMT.
ALOX5 Binding (associated) of
4) Confidence 0.35 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2878676 Disease Relevance 0 Pain Relevance 0
The associations of lipoxygenase pathway gene variants (ALOX SNPs) with measures of atherosclerosis are indirect.
ALOX Binding (associations) of associated with atherosclerosis
5) Confidence 0.35 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2878676 Disease Relevance 0.26 Pain Relevance 0
These two SNPs bound the ALOX5 marginally associated SNP (rs2115819, intron 3).
ALOX5 Binding (associated) of
6) Confidence 0.35 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2878676 Disease Relevance 0 Pain Relevance 0
The associations of lipoxygenase pathway gene variants (ALOX SNPs) with measures of atherosclerosis are indirect.
lipoxygenase pathway gene Binding (associations) of associated with atherosclerosis
7) Confidence 0.35 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2878676 Disease Relevance 0.26 Pain Relevance 0
In exploratory analyses, one ALOX5 SNP (rs2115819 in intron 3) exhibited the strongest (P = .108) association.
ALOX5 Binding (association) of
8) Confidence 0.35 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2878676 Disease Relevance 0 Pain Relevance 0
Furthermore, a significant association between the ALOX5 promoter polymorphism and the severity of airway hyperresponsiveness was detected in the Korean population.23 AIA patients carrying a mutant allele (n ?
ALOX5 Binding (association) of associated with asthma
9) Confidence 0.35 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687575 Disease Relevance 0.45 Pain Relevance 0.10
Polymorphisms within ALOX12, ALOX5, and ALOX5AP are genetically associated with subclinical atherosclerosis and with biomarkers of disease in families with type 2 diabetes.
ALOX5 Binding (associated) of associated with diabetes mellitus, atherosclerosis and disease
10) Confidence 0.34 Published 2010 Journal Mediators of Inflammation Section Abstract Doc Link PMC2878676 Disease Relevance 1.25 Pain Relevance 0.05
We examined whether 5-lipoxygenase (5-LO), the key enzyme involved in biosynthesis of leukotrienes is a possible target for the spices.
5-LO Binding (target) of
11) Confidence 0.33 Published 2004 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 15120715 Disease Relevance 0 Pain Relevance 0.14
No tagging SNP in the four lipoxygenase pathway genes were significantly associated (P < .05) with AorCP (Table 3).
lipoxygenase Binding (associated) of
12) Confidence 0.31 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2878676 Disease Relevance 0 Pain Relevance 0
Our findings are contradictory to previous studies, which found no significant association between LoC and either childhood caries [23] or caries relapse [22].
LoC Neg (no) Binding (association) of associated with recurrence
13) Confidence 0.29 Published 2008 Journal BMC Public Health Section Body Doc Link PMC2442069 Disease Relevance 0.10 Pain Relevance 0
Though both aforementioned linear associations were statistically significant, there was a stronger and unquestionable linearity in the association between LoC and dt, while the same was not exactly the case for the association between LoC and dmft, where the trend did not apply to the 4th and 5th quintiles.
LoC Binding (association) of
14) Confidence 0.29 Published 2008 Journal BMC Public Health Section Body Doc Link PMC2442069 Disease Relevance 0.15 Pain Relevance 0
Though both aforementioned linear associations were statistically significant, there was a stronger and unquestionable linearity in the association between LoC and dt, while the same was not exactly the case for the association between LoC and dmft, where the trend did not apply to the 4th and 5th quintiles.
LoC Binding (association) of
15) Confidence 0.29 Published 2008 Journal BMC Public Health Section Body Doc Link PMC2442069 Disease Relevance 0.14 Pain Relevance 0
BACKGROUND: Licofelone, a potent antiinflammatory agent has been reported to interfere with the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) signaling pathways with few side-effects.
5-LOX Binding (interfere) of associated with inflammation and licofelone
16) Confidence 0.23 Published 2007 Journal Anticancer Res. Section Abstract Doc Link 17695530 Disease Relevance 0.17 Pain Relevance 0.27
The association between parental LoC and children's caries experience (dmft) and level of untreated caries (dt) was analysed using logistic regression.
LoC Spec (analysed) Binding (association) of
17) Confidence 0.22 Published 2008 Journal BMC Public Health Section Body Doc Link PMC2442069 Disease Relevance 0.09 Pain Relevance 0
The findings support the hypothesis that higher internal parental LoC is associated with better control of both untreated caries and caries experience in their preschool children and highlight that a more internal LoC within the family is advantageous in the prevention of dental caries.



LoC Binding (associated) of in internal associated with dental caries
18) Confidence 0.21 Published 2008 Journal BMC Public Health Section Abstract Doc Link PMC2442069 Disease Relevance 0.09 Pain Relevance 0
The main finding of this study is that there was a clear linear association between parental LoC and child's caries status; stronger parental LoC was linked with higher probability of their child being free from untreated dental decay in the primary dentition.
LoC Spec (clear) Binding (association) of in dentition associated with dental caries
19) Confidence 0.21 Published 2008 Journal BMC Public Health Section Body Doc Link PMC2442069 Disease Relevance 0.09 Pain Relevance 0
The study findings support the hypothesis that higher internal parental LoC is associated with better control of both untreated caries and caries experience of their children.
LoC Binding (associated) of in internal
20) Confidence 0.21 Published 2008 Journal BMC Public Health Section Body Doc Link PMC2442069 Disease Relevance 0.05 Pain Relevance 0

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