INT10478

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Context Info
Confidence 0.47
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 25
Total Number 25
Disease Relevance 12.95
Pain Relevance 7.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Alms1) cilium (Alms1) molecular_function (Alms1)
lipid metabolic process (Alms1) cytoplasm (Alms1)
Anatomy Link Frequency
brain 4
endothelial cells 3
T lymphocytes 3
plasma 2
leukocyte 2
Alms1 (Mus musculus)
Pain Link Frequency Relevance Heat
alcohol 2 99.42 Very High Very High Very High
Central nervous system 252 99.36 Very High Very High Very High
Inflammation 173 98.86 Very High Very High Very High
cytokine 77 98.56 Very High Very High Very High
opioid receptor 78 98.16 Very High Very High Very High
Multiple sclerosis 89 97.28 Very High Very High Very High
analgesia 43 94.16 High High
Cannabinoid 10 93.68 High High
Enkephalin 8 92.72 High High
imagery 119 92.08 High High
Disease Link Frequency Relevance Heat
Stress 15 99.80 Very High Very High Very High
Pressure And Volume Under Development 17 99.64 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 115 99.58 Very High Very High Very High
Disease 243 99.38 Very High Very High Very High
Hypothermia 65 99.32 Very High Very High Very High
INFLAMMATION 201 98.86 Very High Very High Very High
Targeted Disruption 194 98.84 Very High Very High Very High
Apoptosis 29 98.52 Very High Very High Very High
Injury 28 97.42 Very High Very High Very High
Multiple Sclerosis 180 97.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Results with the model agree with those obtained in vivo and have been used to study the permeability of the BBB to peptides, the effect of peptides on BBB integrity, the cellular pathway peptides and proteins use to cross the BBB, and the ability of the BBB to degrade peptides.
Protein_catabolism (degrade) of BBB
1) Confidence 0.47 Published 1992 Journal Peptides Section Abstract Doc Link 1494505 Disease Relevance 0 Pain Relevance 0.33
Although peptide neuropharmaceuticals have enormous potential in the treatment of disease states, the blood-brain barrier (BBB) generally prevents the entry of peptides into the brain either by enzyme degradation or by specific properties of the BBB.
Protein_catabolism (degradation) of BBB in brain associated with disease
2) Confidence 0.42 Published 1998 Journal J Pharm Sci Section Abstract Doc Link 9811502 Disease Relevance 0.10 Pain Relevance 0.59
Besides the physical barrier of the endothelial cell wall, there are the following obstacles: protein binding in the circulation; enzymatic degradation in the circulation, at the BBB, or within the CNS; uptake or sequestration by peripheral tissues of the peripherally administered substance; sequestration by the capillaries that comprise the BBB; and efflux, or removal, by CNS-to-blood transporters.
Protein_catabolism (degradation) of BBB in endothelial cell associated with central nervous system
3) Confidence 0.40 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604887 Disease Relevance 0 Pain Relevance 0.21
When the BBB is disrupted, Trypan blue extravasates into tissue, resulting in a grossly visible blue stain [14], and thus has been used classically to demonstrate BBB breakdown.
Protein_catabolism (breakdown) of BBB
4) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2364662 Disease Relevance 0.39 Pain Relevance 0.07
Subsequent rehydration in the presence of normal plasma leads to complete restoration of the BBB about 4 h. following treatment.
Protein_catabolism (restoration) of BBB in plasma
5) Confidence 0.28 Published 2008 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2792490 Disease Relevance 0.53 Pain Relevance 0.07
-cat in vivo modulates Cldn3 and plamalemma vesicle-associated protein (Plvap) expression and BBB permeability
Protein_catabolism (permeability) of BBB in vesicle
6) Confidence 0.17 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2575783 Disease Relevance 0 Pain Relevance 0.03
Our results suggest that Gf enhancement could serve as sensitive marker for different hallmarks of CNS inflammation, including molecular "arming", immune cell recruitment, BBB breakdown and tissue damage.
Protein_catabolism (breakdown) of BBB in immune cell associated with inflammation and central nervous system
7) Confidence 0.17 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2978145 Disease Relevance 0.90 Pain Relevance 0.49
This finding was partially independent from simultaneous BBB breakdown, and the route of entry is still not completely understood [27].
Protein_catabolism (breakdown) of BBB
8) Confidence 0.17 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2978145 Disease Relevance 0.99 Pain Relevance 0.45
Gf tissue enhancement evolved with time delay compared to Gd-DTPA, which indicated BBB breakdown instantly after application.
Protein_catabolism (breakdown) of BBB
9) Confidence 0.17 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2978145 Disease Relevance 0.69 Pain Relevance 0.36
These findings indicate that dystrophin deficiency in the mdx brain leads to severe injury of the endothelial and glial cells with disturbance in alpha-actin cytoskeleton, ZO-1, claudin-1, and AQP4 assembly, as well as BBB breakdown.
Protein_catabolism (breakdown) of BBB in glial cells associated with injury
10) Confidence 0.17 Published 2003 Journal Glia Section Abstract Doc Link 12673830 Disease Relevance 0.18 Pain Relevance 0.13
In search for the signs of BBB damage in the brain of symptomatic A53T mice, we examined the expression and subcellular distribution of aquaporin 4, glucose transporter 1 (Glut1) and von Willebrand factor (vWF) in astrocyte and vascular endothelial cells.
Protein_catabolism (damage) of BBB in endothelial cells associated with targeted disruption
11) Confidence 0.13 Published 2010 Journal Mol Brain Section Body Doc Link PMC2873589 Disease Relevance 0.50 Pain Relevance 0.25
-cat causes significant down-regulation of claudin3 (Cldn3), up-regulation of plamalemma vesicle-associated protein, and BBB breakdown.
Protein_catabolism (breakdown) of BBB in vesicle
12) Confidence 0.13 Published 2008 Journal The Journal of Cell Biology Section Abstract Doc Link PMC2575783 Disease Relevance 0 Pain Relevance 0
These findings may open new therapeutic avenues to modulate endothelial barrier function and to limit the devastating effects of BBB breakdown.



Protein_catabolism (breakdown) of BBB
13) Confidence 0.13 Published 2008 Journal The Journal of Cell Biology Section Abstract Doc Link PMC2575783 Disease Relevance 0 Pain Relevance 0
Although current models hypothesize that immune cells promote vascular permeability in human disease, the role CD8 T cells play in BBB breakdown remains poorly defined.
Protein_catabolism (breakdown) of BBB in T cells associated with disease
14) Confidence 0.12 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2516328 Disease Relevance 0.63 Pain Relevance 0.17
Alcohol and HIV-1 gp120 both affect BBB permeability and stress fiber formation in BMECs [136].
Protein_catabolism (permeability) of BBB associated with stress, acquired immune deficiency syndrome or hiv infection and alcohol
15) Confidence 0.11 Published 2010 Journal Retrovirology Section Body Doc Link PMC2864195 Disease Relevance 1.03 Pain Relevance 0.40
Based on these observations, it is plausible to assume that HBO prevents BBB breakdown and then avoids vascular leakage by down-regulating the inflammatory immune response in ECM, but mainly, by reducing the percentage of brain-sequestered CD8+ T lymphocytes [10].
Protein_catabolism (breakdown) of BBB in T lymphocytes associated with inflammation and cerebral malaria
16) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2518956 Disease Relevance 0.58 Pain Relevance 0.09
and IL-10 cytokine expression and the migration to the brain of T lymphocytes, preventing BBB breakdown and severe mice hypothermia without directly affecting iRBC viability and infectivity.
Protein_catabolism (breakdown) of BBB in T lymphocytes associated with hypothermia and cytokine
17) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2518956 Disease Relevance 0.81 Pain Relevance 0.11
stimulates apoptosis of endothelial cells and contributes to vasogenic edema and, due to this BBB breakdown, infiltration of circulatory inflammatory cells are stimulated [57].
Protein_catabolism (breakdown) of BBB in endothelial cells associated with pressure and volume under development, inflammation and apoptosis
18) Confidence 0.06 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2988764 Disease Relevance 0.62 Pain Relevance 0.24
Moreover, inhibition of BBB breakdown by blockade of leukocyte-endothelial interaction with an anti-VLA-4 antibody has preventive as well as therapeutic effects in a mouse model of epilepsy [10].
Protein_catabolism (breakdown) of BBB in leukocyte associated with epilepsy
19) Confidence 0.06 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2954970 Disease Relevance 1.62 Pain Relevance 0.18
WMLs most probably reflect transient and discrete breakdown of the BBB consequent to sustained cerebral hyperperfusion rather than hypoperfusion.
Protein_catabolism (breakdown) of BBB
20) Confidence 0.06 Published 2009 Journal Expert Rev Neurother Section Abstract Doc Link 19903020 Disease Relevance 1.05 Pain Relevance 1.06

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