INT104789

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Context Info
Confidence 0.33
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Title
Documents 3
Total Number 3
Disease Relevance 0.44
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (REST) nucleolus (REST) nucleus (REST)
intracellular (REST) DNA binding (REST) transcription factor binding (REST)
Anatomy Link Frequency
neuronal 1
nucleus 1
REST (Homo sapiens)
Pain Link Frequency Relevance Heat
sodium channel 1 77.92 Quite High
Nav1.2 1 77.08 Quite High
Opioid 1 76.48 Quite High
mu opioid receptor 1 74.16 Quite High
Calcium channel 11 5.00 Very Low Very Low Very Low
Neurotransmitter 5 5.00 Very Low Very Low Very Low
gABA 2 5.00 Very Low Very Low Very Low
Migraine 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Neuropeptide 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 7 100.00 Very High Very High Very High
Neuroblastoma 1 89.12 High High
Anaplastic Astrocytoma 1 37.76 Quite Low
Disease 4 5.00 Very Low Very Low Very Low
Epilepsy 1 5.00 Very Low Very Low Very Low
Cerebellar Diseases 1 5.00 Very Low Very Low Very Low
Nervous System Malformation 1 5.00 Very Low Very Low Very Low
Adhesions 1 5.00 Very Low Very Low Very Low
Headache 1 5.00 Very Low Very Low Very Low
Ataxia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This resonates with the model of Ballas et al. (45) regarding the progressive loss of REST from target genes during neuronal differentiation, where REST recruitment is lost from those genes with weaker RE1s first, as REST levels in the nucleus drop during development.
Negative_regulation (loss) of REST in nucleus
1) Confidence 0.33 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1557810 Disease Relevance 0.09 Pain Relevance 0
In contrast, knockdown of NRSF by siRNA transfection significantly decreased eIF4G phosphorylation.
Negative_regulation (knockdown) of NRSF
2) Confidence 0.29 Published 2008 Journal Biochim. Biophys. Acta Section Abstract Doc Link 18657578 Disease Relevance 0.09 Pain Relevance 0.11
REST repression of neuronal genes requires components of the hSWI.SNF complex.
Negative_regulation (repression) of REST in neuronal associated with repression
3) Confidence 0.03 Published 2002 Journal J. Biol. Chem. Section Title Doc Link 12192000 Disease Relevance 0.26 Pain Relevance 0.12

General Comments

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