INT104804

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Context Info
Confidence 0.66
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.88
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TK1) small molecule metabolic process (TK1) kinase activity (TK1)
cytoplasm (TK1)
Anatomy Link Frequency
TK-1 3
TK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 37 88.32 High High
positron emission tomography 50 86.88 High High
Chronic pancreatitis 4 82.16 Quite High
peripheral neuropathy 5 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 56 99.76 Very High Very High Very High
Pancreatic Cancer 20 99.68 Very High Very High Very High
Cancer 52 99.48 Very High Very High Very High
Immunotherapy Of Cancer 1 91.68 High High
Pancreatitis 4 82.16 Quite High
Toxicity 18 66.48 Quite High
Lung Cancer 3 56.16 Quite High
Malignant Neoplastic Disease 3 36.08 Quite Low
Carcinoma 6 5.00 Very Low Very Low Very Low
Peripheral Neuropathy 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TK-1 and thymidine synthetase mRNA were increased in six pancreatic cancer cell lines, while mRNA levels of thymidine kinase 2 and deoxycytidine kinase were down-regulated.
Positive_regulation (increased) of TK-1 in TK-1 associated with pancreatic cancer
1) Confidence 0.66 Published 2002 Journal Eur. J. Nucl. Med. Mol. Imaging Section Abstract Doc Link 12192562 Disease Relevance 0.68 Pain Relevance 0.16
TK-1 and thymidine synthetase mRNA were increased in six pancreatic cancer cell lines, while mRNA levels of thymidine kinase 2 and deoxycytidine kinase were down-regulated.
Positive_regulation (increased) of thymidine synthetase mRNA in TK-1 associated with pancreatic cancer
2) Confidence 0.66 Published 2002 Journal Eur. J. Nucl. Med. Mol. Imaging Section Abstract Doc Link 12192562 Disease Relevance 0.68 Pain Relevance 0.16
Consequently, TK-1 is closely associated with DNA synthesis and is significantly increased in rapidly proliferating cells and therefore is over-expressed in many tumors.
Positive_regulation (increased) of TK-1 in TK-1 associated with cancer
3) Confidence 0.30 Published 2007 Journal BMC Nucl Med Section Body Doc Link PMC1931583 Disease Relevance 0.65 Pain Relevance 0.36
WalBC cells exhibited expression of known markers of basal invasive human breast cancers as well as increased KRT17, KRT 14 and KRT 19, DSP, s100A4, NDRG-1, ANXA1, TK1 and AQP3 gene expression and decreased gene expression of TIMP3, VIM and TAGLN.
Positive_regulation (increased) of TK1 associated with breast cancer
4) Confidence 0.07 Published 2008 Journal Mol Cancer Section Abstract Doc Link PMC2263075 Disease Relevance 0.87 Pain Relevance 0

General Comments

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