INT104831

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Context Info
Confidence 0.08
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 5
Disease Relevance 0
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (GLI2, NFKB1) nucleus (GLI2, NFKB1) nucleoplasm (NFKB1)
cell differentiation (GLI2) mitochondrion (NFKB1) intracellular (GLI2)
Anatomy Link Frequency
THP-1 4
macrophage 1
GLI2 (Homo sapiens)
NFKB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 15 100.00 Very High Very High Very High
Opioid 5 97.26 Very High Very High Very High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Endomorphins 1 and 2 inhibit IL-10 and IL-12 production and innate immune functions, and potentiate NF-kappaB DNA binding in THP-1 differentiated to macrophage-like cells.
THP-1 Binding (binding) of NF-kappaB in THP-1 associated with cytokine
1) Confidence 0.08 Published 2002 Journal Scand. J. Immunol. Section Title Doc Link 12193227 Disease Relevance 0 Pain Relevance 0.22
These results suggest that endomorphins 1 and 2 may inhibit THP-1 functions, such as cytokine production and functions related to innate immune, and potentiate NF-kappaB DNA binding in THP-1.
THP-1 Binding (binding) of NF-kappaB in THP-1 associated with cytokine
2) Confidence 0.07 Published 2002 Journal Scand. J. Immunol. Section Abstract Doc Link 12193227 Disease Relevance 0 Pain Relevance 0.14
In addition, endomorphins 1 and 2 led to marked potentiation of NF-kappaB binding in THP-1 differentiated to macrophage-like cells.
THP-1 Binding (binding) of NF-kappaB in macrophage
3) Confidence 0.06 Published 2002 Journal Scand. J. Immunol. Section Abstract Doc Link 12193227 Disease Relevance 0 Pain Relevance 0.15
These results suggest that endomorphins 1 and 2 may inhibit THP-1 functions, such as cytokine production and functions related to innate immune, and potentiate NF-kappaB DNA binding in THP-1.
THP-1 Binding (binding) of NF-kappaB in THP-1 associated with cytokine
4) Confidence 0.06 Published 2002 Journal Scand. J. Immunol. Section Abstract Doc Link 12193227 Disease Relevance 0 Pain Relevance 0.14
We evaluated immunological effects of opioid peptides endomorphins 1 and 2 on the production of interleukin-10 (IL-10) and IL-12 cytokines, functions related to innate immunity and NF-kappaB DNA binding in human cell line THP-1.
THP-1 Binding (binding) of NF-kappaB in THP-1 associated with opioid and cytokine
5) Confidence 0.05 Published 2002 Journal Scand. J. Immunol. Section Abstract Doc Link 12193227 Disease Relevance 0 Pain Relevance 0.15

General Comments

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