INT104831

Context Info Confidence 0.08 First Reported 2002 Last Reported 2002 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 5 Disease Relevance 0 Pain Relevance 0.80

cytoplasm (GLI2, NFKB1) nucleus (GLI2, NFKB1) nucleoplasm (NFKB1) cell differentiation (GLI2) mitochondrion (NFKB1) intracellular (GLI2)

Anatomy Link Frequency THP-1 4 macrophage 1 GLI2 (Homo sapiens) NFKB1 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 15 100.00 Opioid 5 97.26

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Anatomy

Negation

Speculation

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Disease term

Endomorphins 1 and 2 inhibit IL-10 and IL-12 production and innate immune functions, and potentiate NF-kappaB DNA binding in THP-1 differentiated to macrophage-like cells.

THP-1 Binding (binding) of NF-kappaB in THP-1 associated with cytokine

1) Confidence 0.08 Published 2002 Journal Scand. J. Immunol. Section Title Doc Link 12193227 Disease Relevance 0 Pain Relevance 0.22

These results suggest that endomorphins 1 and 2 may inhibit THP-1 functions, such as cytokine production and functions related to innate immune, and potentiate NF-kappaB DNA binding in THP-1.

THP-1 Binding (binding) of NF-kappaB in THP-1 associated with cytokine

2) Confidence 0.07 Published 2002 Journal Scand. J. Immunol. Section Abstract Doc Link 12193227 Disease Relevance 0 Pain Relevance 0.14

In addition, endomorphins 1 and 2 led to marked potentiation of NF-kappaB binding in THP-1 differentiated to macrophage-like cells.

THP-1 Binding (binding) of NF-kappaB in macrophage

3) Confidence 0.06 Published 2002 Journal Scand. J. Immunol. Section Abstract Doc Link 12193227 Disease Relevance 0 Pain Relevance 0.15

These results suggest that endomorphins 1 and 2 may inhibit THP-1 functions, such as cytokine production and functions related to innate immune, and potentiate NF-kappaB DNA binding in THP-1.

THP-1 Binding (binding) of NF-kappaB in THP-1 associated with cytokine

4) Confidence 0.06 Published 2002 Journal Scand. J. Immunol. Section Abstract Doc Link 12193227 Disease Relevance 0 Pain Relevance 0.14

We evaluated immunological effects of opioid peptides endomorphins 1 and 2 on the production of interleukin-10 (IL-10) and IL-12 cytokines, functions related to innate immunity and NF-kappaB DNA binding in human cell line THP-1.

THP-1 Binding (binding) of NF-kappaB in THP-1 associated with opioid and cytokine

5) Confidence 0.05 Published 2002 Journal Scand. J. Immunol. Section Abstract Doc Link 12193227 Disease Relevance 0 Pain Relevance 0.15

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