INT104835

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Context Info
Confidence 0.32
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.91
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (IL10) DNA binding (IRF6) cell-cell signaling (IL10)
response to stress (IL10) cytoplasm (IRF6) cytosol (IRF6)
Anatomy Link Frequency
monocytes 1
amnion 1
IRF6 (Homo sapiens)
IL10 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 105 96.40 Very High Very High Very High
Inflammation 59 95.04 Very High Very High Very High
Opioid 1 84.12 Quite High
Inflammatory stimuli 8 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sarcoidosis 40 99.04 Very High Very High Very High
INFLAMMATION 76 95.04 Very High Very High Very High
Disease 9 79.60 Quite High
Necrosis 4 78.64 Quite High
Cancer 4 78.28 Quite High
Lymphocytosis 1 77.68 Quite High
Syndrome 19 68.64 Quite High
Candida Infection 2 67.20 Quite High
Pre-term Labor 8 57.68 Quite High
Infection 29 41.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly, they suppressed LPS-stimulated IL-10 and IL-12 production in THP-1 matured to monocytes by 1alpha,25-dihydroxyvitamin D3.
LPS Positive_regulation (stimulated) of IL-10 in monocytes
1) Confidence 0.32 Published 2002 Journal Scand. J. Immunol. Section Abstract Doc Link 12193227 Disease Relevance 0 Pain Relevance 0.16
from human gestational membranes in Transwell cultures [23], and show for the first time that releases of IL-6, IL-8 and IL-10 are stimulated by LPS in a side-specific manner from human gestational membranes.
LPS Positive_regulation (stimulated) of IL-10
2) Confidence 0.03 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2774314 Disease Relevance 0.21 Pain Relevance 0.23
Moreover, LPS treatment of the amnion side failed to increase IL-10 or IL-8 on the amniotic side of the membranes yet increased IL-10 and IL-8 on the choriodecidual side, indicating that the inflammatory signal, but not the cytokine itself, most likely propagated across the membranes from the amnion to the choriodecidua.
LPS Neg (failed) Positive_regulation (increase) of IL-10 in amnion associated with inflammation and cytokine
3) Confidence 0.03 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2774314 Disease Relevance 0.37 Pain Relevance 0.30
In addition, LPS significantly upregulated IL-10 in healthy controls.
LPS Positive_regulation (upregulated) of IL-10
4) Confidence 0.02 Published 2010 Journal Respir Res Section Body Doc Link PMC2939603 Disease Relevance 0.32 Pain Relevance 0

General Comments

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