INT104836

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Context Info
Confidence 0.01
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL10) extracellular region (IL10) intracellular (IL10)
cell-cell signaling (IL10) response to stress (IL10)
Anatomy Link Frequency
THP-1 4
IGKV2OR2-1 (Homo sapiens)
IL10 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 6 100.00 Very High Very High Very High
Opioid 2 93.80 High High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Endomorphins 1 and 2 inhibit IL-10 and IL-12 production and innate immune functions, and potentiate NF-kappaB DNA binding in THP-1 differentiated to macrophage-like cells.
Endomorphins 1 and 2 Negative_regulation (inhibit) of Gene_expression (production) of IL-10 in THP-1 associated with cytokine
1) Confidence 0.01 Published 2002 Journal Scand. J. Immunol. Section Title Doc Link 12193227 Disease Relevance 0 Pain Relevance 0.22
Endomorphins 1 and 2 inhibited lipopolysaccharide (LPS)-stimulated IL-10 and IL-12 production in THP-1 differentiated to macrophage-like cells by phorbol 12-myristate 13-acetate (PMA).
Endomorphins 1 and 2 Negative_regulation (inhibited) of Gene_expression (production) of IL-10 in THP-1
2) Confidence 0.01 Published 2002 Journal Scand. J. Immunol. Section Abstract Doc Link 12193227 Disease Relevance 0 Pain Relevance 0.14

General Comments

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