INT104839

Context Info Confidence 0.35 First Reported 2002 Last Reported 2010 Negated 0 Speculated 1 Reported most in Abstract Documents 8 Total Number 10 Disease Relevance 2.70 Pain Relevance 1.24

cell differentiation (GLI2) cell proliferation (GLI2) nucleus (GLI2) intracellular (GLI2) cilium (GLI2) cytoplasm (GLI2)

Anatomy Link Frequency THP-1 6 monocytes 2 GLI2 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 19 99.20 Kappa opioid receptor 8 96.00 metalloproteinase 4 92.64 Opioid 5 91.76 agonist 13 83.32 opioid receptor 1 76.92 Mechanotransduction 16 58.80 Inflammation 23 58.56 rheumatoid arthritis 68 50.44 Inflammatory response 3 44.32

Disease Link Frequency Relevance Heat Rheumatoid Arthritis 71 98.56 Osteolysis 6 98.44 Metastasis 49 97.76 Apoptosis 86 88.48 Death 17 86.96 Leukemia 54 81.76 Cancer 120 79.52 Disease 26 78.40 Adhesions 11 76.72 Hypertension 2 73.00

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Preclinical studies have indicated that inhibiting Gli2 activity reduces PTHrP expression and osteolysis [48].

Negative_regulation (inhibiting) of Gli2 associated with osteolysis

1) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.52 Pain Relevance 0.03

Preclinical studies have indicated that inhibiting Gli2 activity reduces PTHrP expression and osteolysis [48].

Negative_regulation (inhibiting) of Gli2 associated with osteolysis

2) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.52 Pain Relevance 0.03

In both THP-1 and transfected COS-7 cells, pretreatment of the selective Src family kinase inhibitor pyrazolopyrimidine PP1 abolished the JNK activation, whereas the epidermal growth factor receptor inhibitor AG1478 [N-(3-chlorophenyl)-6,7-dimethoxy-4-quinazolinanine] failed to do that.

Negative_regulation (abolished) of THP-1 in THP-1

3) Confidence 0.11 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14996948 Disease Relevance 0.15 Pain Relevance 0.44

Similarly, they suppressed LPS-stimulated IL-10 and IL-12 production in THP-1 matured to monocytes by 1alpha,25-dihydroxyvitamin D3.

Negative_regulation (suppressed) of THP-1 in monocytes

4) Confidence 0.11 Published 2002 Journal Scand. J. Immunol. Section Abstract Doc Link 12193227 Disease Relevance 0 Pain Relevance 0.16

Moreover, they inhibited chemotaxis, phagocytosis of Escherichia coli and PMA-stimulated production of hydrogen peroxide in THP-1 differentiated to macrophage-like cells.

Negative_regulation (inhibited) of THP-1 in THP-1

5) Confidence 0.11 Published 2002 Journal Scand. J. Immunol. Section Abstract Doc Link 12193227 Disease Relevance 0 Pain Relevance 0.15

Endomorphins 1 and 2 inhibited lipopolysaccharide (LPS)-stimulated IL-10 and IL-12 production in THP-1 differentiated to macrophage-like cells by phorbol 12-myristate 13-acetate (PMA).

Negative_regulation (inhibited) of THP-1 in THP-1

6) Confidence 0.11 Published 2002 Journal Scand. J. Immunol. Section Abstract Doc Link 12193227 Disease Relevance 0 Pain Relevance 0.14

These results suggest that endomorphins 1 and 2 may inhibit THP-1 functions, such as cytokine production and functions related to innate immune, and potentiate NF-kappaB DNA binding in THP-1.

Spec (may) Negative_regulation (inhibit) of THP-1 in THP-1 associated with cytokine

7) Confidence 0.11 Published 2002 Journal Scand. J. Immunol. Section Abstract Doc Link 12193227 Disease Relevance 0 Pain Relevance 0.15

In the THP-1 cultures displaying suppressed survivin expression, a significant downregulation (P < 0.01) of IL-6 production was observed, decreasing from 100% to 21–30% (Fig. 5c).

Negative_regulation (downregulation) of THP-1 in THP-1

8) Confidence 0.05 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065333 Disease Relevance 0.28 Pain Relevance 0.05

Western blotting with a rabbit polyclonal anti-27-hydroxylase antibody [11] showed a concomitant decrease in 27-hydroxylase protein in THP-1 monocytes exposed to NS398 (Figure 1b).

Negative_regulation (decrease) of THP-1 in monocytes

9) Confidence 0.03 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0 Pain Relevance 0

A reduction in THP-1 cell

Negative_regulation (reduction) of THP-1 in THP-1

10) Confidence 0.03 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 1.22 Pain Relevance 0.09

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