INT104840

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Context Info
Confidence 0.08
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 1.89
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (GLI2) cell proliferation (GLI2) nucleus (GLI2)
intracellular (GLI2) cilium (GLI2) cytoplasm (GLI2)
Anatomy Link Frequency
THP-1 4
macrophages 2
monocytes 1
GLI2 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 5 99.12 Very High Very High Very High
cytokine 16 98.38 Very High Very High Very High
COX-2 inhibitor 26 94.56 High High
antagonist 4 88.64 High High
metalloproteinase 6 81.40 Quite High
agonist 17 59.44 Quite High
Opioid 1 57.48 Quite High
cINOD 22 5.00 Very Low Very Low Very Low
Inflammation 19 5.00 Very Low Very Low Very Low
Pain 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 68 100.00 Very High Very High Very High
Necrosis 3 100.00 Very High Very High Very High
Leukemia 56 87.28 High High
Metastasis 3 85.60 High High
Infection 40 80.64 Quite High
Toxicity 1 79.08 Quite High
Rheumatoid Arthritis 4 74.88 Quite High
Myeloid Leukemia 28 61.28 Quite High
Epstein-barr Virus 2 60.20 Quite High
Myelodysplastic Syndromes 4 57.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that endomorphins 1 and 2 may inhibit THP-1 functions, such as cytokine production and functions related to innate immune, and potentiate NF-kappaB DNA binding in THP-1.
THP-1 Binding (binding) of in THP-1 associated with cytokine
1) Confidence 0.08 Published 2002 Journal Scand. J. Immunol. Section Abstract Doc Link 12193227 Disease Relevance 0 Pain Relevance 0.14
It seems unlikely that MCP-1 is the chemokine responsible for platelet releasate-induced THP-1 migration because 100?
THP-1 Binding (migration) of in THP-1 associated with chemokine
2) Confidence 0.04 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2846341 Disease Relevance 0 Pain Relevance 0.17
THP-1 migration was measured using a Boyden chamber assay.
THP-1 Binding (migration) of in THP-1
3) Confidence 0.04 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2846341 Disease Relevance 0.09 Pain Relevance 0
Under conditions of cholesterol loading with acetylated LDL, THP-1 macrophages treated with NS398 exhibited greater propensity to form lipid-laden foam cells as compared to untreated cells.
THP-1 Binding (macrophages) of in macrophages
4) Confidence 0.03 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0 Pain Relevance 0.14
An example of two cell types with strong binding (Vero and BEAS-2B cells) and two others with undetectable binding (THP-1 and primary monocytes) is provided in Figure 5, while Table 1 summarizes results obtained with the whole panel of tested cells.
THP-1 Binding (binding) of in monocytes
5) Confidence 0.03 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1904475 Disease Relevance 0.47 Pain Relevance 0
Reversal of NS398-induced downregulation of 27-hydroxylase and ABCA1 message by PGE2 and PGD2 was also observed in THP-1 macrophages (Figure 6).
THP-1 Binding (macrophages) of in macrophages
6) Confidence 0.03 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0 Pain Relevance 0.16
factor, can induce THP-1 apoptosis and necrosis by inducing PPAR?
THP-1 Binding (necrosis) of in THP-1 associated with necrosis and apoptosis
7) Confidence 0.02 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 1.33 Pain Relevance 0.11

General Comments

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