INT104858

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Context Info
Confidence 0.10
First Reported 2002
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.41
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Prkaca, TRPV1) transport (TRPV1) mitochondrion (Prkaca)
Golgi apparatus (Prkaca) protein complex (Prkaca) lipid metabolic process (TRPV1)
Prkaca (Mus musculus)
TRPV1 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 10 98.08 Very High Very High Very High
IPN 1 94.20 High High
Kinase C 2 73.92 Quite High
Stimulus evoked pain 1 68.08 Quite High
Pain 2 25.00 Low Low
nociceptor 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Inflammatory Pain 2 94.20 High High
Nociception 2 91.64 High High
Hypersensitivity 1 67.68 Quite High
Injury 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we demonstrate that PKA reduces VR1 desensitization and directly phosphorylates VR1.
PKA Negative_regulation (reduces) of Negative_regulation (desensitization) of VR1
1) Confidence 0.10 Published 2002 Journal Neuron Section Abstract Doc Link 12194871 Disease Relevance 0.23 Pain Relevance 0.33
The cAMP-dependent protein kinase (PKA) decreases desensitization of TRPV1 by directly phosphorylating the channel presumably at sites Ser116 and Thr370.
PKA Negative_regulation (decreases) of Negative_regulation (desensitization) of TRPV1
2) Confidence 0.03 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15691846 Disease Relevance 0.19 Pain Relevance 0.31

General Comments

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