INT104883

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Context Info
Confidence 0.45
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 4.05
Pain Relevance 1.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bax) endoplasmic reticulum (Bax) intracellular (Bax)
cytoplasm (Bax) cytosol (Bax) cell proliferation (Bax)
Anatomy Link Frequency
retina 2
spinal cord dorsal horn 2
Bax (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 9 99.68 Very High Very High Very High
Spinal cord 2 97.08 Very High Very High Very High
Dorsal horn 2 96.60 Very High Very High Very High
tolerance 5 96.52 Very High Very High Very High
antagonist 1 92.20 High High
ischemia 34 90.48 High High
Glutamate 1 89.04 High High
gABA 1 78.60 Quite High
Neurotransmitter 1 78.40 Quite High
Opioid 5 75.00 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 106 99.32 Very High Very High Very High
Neurodegenerative Disease 10 97.44 Very High Very High Very High
Glaucoma 19 95.96 Very High Very High Very High
Death 27 95.28 Very High Very High Very High
Stress 35 93.76 High High
Coronary Artery Disease 2 90.48 High High
Ocular Hypertension 83 88.08 High High
Parkinson's Disease 3 86.56 High High
Nociception 2 80.08 Quite High
Hypoxia 4 78.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At the intracellular level, prolonged morphine administration resulted in an upregulation of the proapoptotic caspase-3 and Bax proteins but a downregulation of the antiapoptotic Bcl-2 protein in the spinal cord dorsal horn.
Positive_regulation (resulted) of Positive_regulation (upregulation) of Bax in spinal cord dorsal horn associated with dorsal horn, spinal cord and morphine
1) Confidence 0.45 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12196588 Disease Relevance 0.74 Pain Relevance 1.61
Therefore, it would be interesting to study Bnip3-induced activation of Bax and Bak and to analyze whether Bnip-3 could also be associated with the increase in apoptosis observed after I/R in the retina.
Positive_regulation (induced) of Positive_regulation (activation) of Bax in retina associated with apoptosis
2) Confidence 0.41 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.77 Pain Relevance 0.07
Increased activation of Bax and Bid in CCl4 treated rats indicates apoptosis is more in these rats.
Positive_regulation (Increased) of Positive_regulation (activation) of Bax associated with apoptosis
3) Confidence 0.28 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2967507 Disease Relevance 0.88 Pain Relevance 0.06
However, taurine treatment inhibited As-induced up-regulation of Bad, Bax and down-regulation of Bcl-2, Bcl-xL.
Positive_regulation (induced) of Positive_regulation (regulation) of Bax
4) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0.71 Pain Relevance 0
More important, the attenuation of ubiquitination in axons may result in accumulation of several proapoptotic proteins (e.g., caspases, Bax and Bad) known to be degraded by the proteasome [20] and thus contributes to axonal degeneration in glaucoma.
Spec (may) Positive_regulation (result) of Positive_regulation (accumulation) of Bax associated with glaucoma
5) Confidence 0.20 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.95 Pain Relevance 0

General Comments

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