INT104899

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Context Info
Confidence 0.39
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 3.47
Pain Relevance 2.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Accn2) plasma membrane (Accn2)
Anatomy Link Frequency
Muscle 1
paw 1
Accn2 (Mus musculus)
Pain Link Frequency Relevance Heat
ASIC 28 98.96 Very High Very High Very High
Inflammation 28 97.62 Very High Very High Very High
Neuropeptide 3 96.84 Very High Very High Very High
IPN 11 96.00 Very High Very High Very High
Inflammatory response 1 94.80 High High
Pain 24 92.64 High High
Root ganglion neuron 1 91.76 High High
Hyperalgesia 12 78.96 Quite High
ischemia 6 66.92 Quite High
PcTx1 3 66.48 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 3 99.00 Very High Very High Very High
INFLAMMATION 30 97.62 Very High Very High Very High
Inflammatory Pain 11 96.00 Very High Very High Very High
Ganglion Cysts 4 94.52 High High
Nociception 1 93.80 High High
Sprains And Strains 1 92.92 High High
Pain 18 92.64 High High
Aids-related Complex 8 91.12 High High
Acidosis 17 86.16 High High
Hyperalgesia 12 79.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mutation of five amino acids in a region of the extracellular domain changed the characteristics of human ASIC1a to those of mouse ASIC1a, suggesting that this region plays a pivotal role in neuropeptide and pH sensitivity of steady-state desensitization.
Regulation (changed) of ASIC1a associated with neuropeptide
1) Confidence 0.39 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 17984098 Disease Relevance 0.40 Pain Relevance 0.30
Alternative splicing and interaction with di- and polyvalent cations control the dynamic range of acid-sensing ion channel 1 (ASIC1).
Regulation (control) of ASIC1
2) Confidence 0.36 Published 2002 Journal J. Biol. Chem. Section Title Doc Link 12198124 Disease Relevance 0.15 Pain Relevance 0.09
Muscle inflammation causes bilateral increases of ASIC2 and ASIC3 but not ASIC1 (neither ASIC1a nor ASIC1b) mRNA, suggesting differential regulation of ASIC1 versus ASIC2 and ASIC3 mRNA.
Regulation (regulation) of ASIC1 in Muscle associated with inflammation
3) Confidence 0.27 Published 2010 Journal J Pain Section Abstract Doc Link 20015700 Disease Relevance 1.28 Pain Relevance 0.65
We investigated the participation of ASIC1a, a particular isoform of ASICs, in retinal physiology in vivo using electroretinogram measurements.
Spec (investigated) Regulation (participation) of ASIC1a associated with asic
4) Confidence 0.25 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16723538 Disease Relevance 0.17 Pain Relevance 0.16
This was achieved by (1) direct comparison of the sensitivity of ASIC1, ASIC2, ASIC3 and TRPV1 knockout mice versus wildtype littermates to acute thermal and mechanical noxious stimuli and (2) studying the behavioural responses of each transgenic strain to hind paw inflammation with either complete Freund's adjuvant (CFA) or formalin.
Regulation (sensitivity) of ASIC1 in paw associated with targeted disruption, inflammation and sprains and strains
5) Confidence 0.24 Published 2009 Journal Eur J Pain Section Abstract Doc Link 18801682 Disease Relevance 0.90 Pain Relevance 0.59
The resistance of ASIC3 to polyamines differs from the modulation of ASIC1a by spermine [29,30] and the modulation of TRPV1 by polyamines [24], arguing for multifunctional roles of arginine metabolites in inflammatory responses [40].
Regulation (modulation) of ASIC1a associated with inflammatory response
6) Confidence 0.08 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.58 Pain Relevance 0.27

General Comments

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