INT104902

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Context Info
Confidence 0.51
First Reported 2002
Last Reported 2011
Negated 2
Speculated 3
Reported most in Body
Documents 6
Total Number 16
Disease Relevance 5.17
Pain Relevance 3.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ASIC1) transport (ASIC1) plasma membrane (ASIC1)
Anatomy Link Frequency
external 1
peripheral nervous system 1
synapses 1
ASIC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
ASIC 133 100.00 Very High Very High Very High
Neuropeptide 4 99.48 Very High Very High Very High
Pain 20 99.12 Very High Very High Very High
Peripheral nervous system 1 98.64 Very High Very High Very High
Multiple sclerosis 10 93.48 High High
ischemia 10 92.36 High High
Inflammation 9 88.64 High High
Glutamate receptor 10 81.76 Quite High
Root ganglion neuron 1 81.00 Quite High
Central nervous system 10 78.40 Quite High
Disease Link Frequency Relevance Heat
Influenza Virus Infection 27 100.00 Very High Very High Very High
Toxicity 61 99.12 Very High Very High Very High
Pain 18 99.12 Very High Very High Very High
Acidosis 44 98.80 Very High Very High Very High
Disease 47 98.56 Very High Very High Very High
Convulsion 10 95.08 Very High Very High Very High
Brain Injury 10 93.52 High High
Demyelinating Disease 10 93.48 High High
Cv Unclassified Under Development 10 92.36 High High
Neurological Disease 10 91.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, PICK1 2K-E had no effect on ASIC1a:PICK1 interaction (Figure 3).
Neg (no) Regulation (effect) of ASIC1a
1) Confidence 0.51 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.14 Pain Relevance 0
As expected, PICK1 KD-AA had no effect on ASIC1a surface levels (surface ASIC1a ratio with PICK1 KA-AA: 5.42% ± 1.6%, p < 0.05 comparing to ASIC1a + PICK1, not significant comparing to ASIC1a alone or ASIC1a + PICK1 2K-E, n = 4, Figure 1C).
Neg (no) Regulation (effect) of ASIC1a
2) Confidence 0.44 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0.04
PICK1 regulates ASIC1a-mediated acidotoxicity in a lipid-binding dependent manner
Regulation (regulates) of ASIC1a
3) Confidence 0.37 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.35 Pain Relevance 0
Our results here may provide one possible mechanism for regulating ASIC1a targeting to synapses.
Spec (possible) Regulation (regulating) of ASIC1a in synapses
4) Confidence 0.37 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0.11
To gain insight into the functional significance of PICK1-regulated trafficking of ASIC1a, we examined PICK1's role in acidosis-induced cell toxicity.
Regulation (regulated) of ASIC1a associated with toxicity and acidosis
5) Confidence 0.37 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.41 Pain Relevance 0
Regulation of ASIC activity by ASIC4--new insights into ASIC channel function revealed by a yeast two-hybrid assay.
Regulation (Regulation) of ASIC associated with asic
6) Confidence 0.24 Published 2008 Journal Eur. J. Neurosci. Section Title Doc Link 18662336 Disease Relevance 0.08 Pain Relevance 0.31
Furthermore, the interaction of PICK1 with ASIC1a was found to be regulated by protein kinases [40,41].
Regulation (regulated) of ASIC1a
7) Confidence 0.22 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.19 Pain Relevance 0.03
However, molecular mechanism regulating ASIC1a trafficking is not well understood.
Regulation (regulating) of ASIC1a
8) Confidence 0.22 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.77 Pain Relevance 0.41
Our results here provide the first evidence that two domains (the BAR and PDZ domain) within PICK1 cooperatively regulate ASIC1a, and consequently its surface expression.
Regulation (regulate) of ASIC1a
9) Confidence 0.22 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.49 Pain Relevance 0.09
Our result that PICK1 increases surface levels of ASIC1a and ASIC1a-mediated acidotoxicity provides an interesting way to regulate ASIC1a in acid-induced cell toxicity.
Regulation (regulate) of ASIC1a associated with toxicity
10) Confidence 0.22 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.59 Pain Relevance 0.08
Several studies have examined the modulation of ASIC1a channel activity by redox reagents, divalent ions, and peptides [18-24].
Spec (examined) Regulation (modulation) of ASIC1a
11) Confidence 0.22 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.75 Pain Relevance 0.43
NO therefore has a direct external effect on the ASIC ion channel, probably through oxidization of cysteine residues.
Regulation (effect) of ASIC in external associated with asic
12) Confidence 0.20 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 18045919 Disease Relevance 0.57 Pain Relevance 0.74
Our results suggest that the ASIC1b/3 heteromer is a possible target for RFamide neuropeptides in the peripheral nervous system.
Spec (possible) Regulation (target) of ASIC1b in peripheral nervous system associated with peripheral nervous system and neuropeptide
13) Confidence 0.18 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16549075 Disease Relevance 0.28 Pain Relevance 0.43
This effect could also be observed on endogenous H+-gated currents in TSA-201 cells and ASIC3 currents in CHO-K1 cells, suggesting a physiological role for ASIC4 in regulating ASIC currents involved in pain mechanisms.
Regulation (regulating) of ASIC associated with pain and asic
14) Confidence 0.12 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18662336 Disease Relevance 0.10 Pain Relevance 0.33
Alternative splicing and interaction with di- and polyvalent cations control the dynamic range of acid-sensing ion channel 1 (ASIC1).
Regulation (control) of ion channel 1
15) Confidence 0.02 Published 2002 Journal J. Biol. Chem. Section Title Doc Link 12198124 Disease Relevance 0.15 Pain Relevance 0.09
These drugs mainly target three influenza envelope proteins: hemagglutinin, neuraminidase, and the matrix 2 ion channel protein.
Regulation (target) of matrix 2 ion channel protein associated with influenza virus infection
16) Confidence 0.01 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2957173 Disease Relevance 0.31 Pain Relevance 0.03

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